초록 ▼

The present invention comprises a composition comprising a matrix adapted to be placed in drug-and permeation-enhancing mixture-transmitting relation to a selected skin or other body site. The matrix contains sufficient amounts of drug, permeation enhancer(s) and poly-N-vinylamide to continuously ad

The present invention comprises a composition comprising a matrix adapted to be placed in drug-and permeation-enhancing mixture-transmitting relation to a selected skin or other body site. The matrix contains sufficient amounts of drug, permeation enhancer(s) and poly-N-vinylamide to continuously administer to the site, the drug, in a therapeutically effective amount, and the permeation-enhancing mixture, in an amount effective to enhance the permeation of the skin to the drug. The device shows increased transdermal flux, as compared to the transdermal flux of the drug from a device containing no poly-N-vinyl amide. Incorporating poly-N-vinyl amide into the transdermal system also improves the adhesion and stability of the system.

대표청구항 ▼

[ What is claimed is:] [1.] A device for the transdermal administration of a drug at a therapeutically effective rate comprising:(a) a reservoir comprising:(i) 1-40 wt % of a transdermally administerable drug;(ii) 30-70 wt % of a polymeric matrix comprising ethylene vinyl acetate copolymer having 9-

[ What is claimed is:] [1.] A device for the transdermal administration of a drug at a therapeutically effective rate comprising:(a) a reservoir comprising:(i) 1-40 wt % of a transdermally administerable drug;(ii) 30-70 wt % of a polymeric matrix comprising ethylene vinyl acetate copolymer having 9-60% vinyl acetate content;(iii) 10-40 wt % of a monoglyceride or a mixture of monoglycerides of a fatty acid with a total monoesters content of at least 51% or a lactic ester of an alcohol, separately or in combination; and(iv) 5-25 wt % poly-N-vinyl-2-pyrrolidone;(b) a backing adjacent the skin-distal surface of the device; and(c) means for maintaining the reservoir in drug- and permeation enhancer-transmitting relation with the skin.