Slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a pol
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B32B-027/00
출원번호
US-0382318
(1995-02-01)
발명자
/ 주소
Hostettler Fritz
Rhum David
Forman Michael R.
Helmus Michael N.
Ding Ni
출원인 / 주소
Schneider Inc.
대리인 / 주소
Vidas, Arrett & Steinkraus
인용정보
피인용 횟수 :
97인용 특허 :
26
초록▼
Slippery, hydrophilic coating compositions of a polyurethane/urea prepolymer adduct intermediate commingled with at least one dissimilar hydrogel polymer precursor, and materials composed of a polymeric plastic or rubber substrate or a metallic substrate with a slippery hydrogel coating of a polyure
Slippery, hydrophilic coating compositions of a polyurethane/urea prepolymer adduct intermediate commingled with at least one dissimilar hydrogel polymer precursor, and materials composed of a polymeric plastic or rubber substrate or a metallic substrate with a slippery hydrogel coating of a polyurethane/urea prepolymer adduct intermediate and at least one dissimilar hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
대표청구항▼
[ We claim:] [1.] A material bearing thereon a coating of a wet, slippery, tenaciously adhering, commingled hydrogel of a hydrophilic polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel, said material and coating comprising:a) a hydrophilic or hydrophilicized hydro
[ We claim:] [1.] A material bearing thereon a coating of a wet, slippery, tenaciously adhering, commingled hydrogel of a hydrophilic polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel, said material and coating comprising:a) a hydrophilic or hydrophilicized hydrophobic polymer substrate or a metal substrate, having a surface with reactive chemical functional groups thereon, at least some of which are amine-containing groups;b) a first coating, applied onto said substrate surface, said first coating being a hydrophilic polyurethane-urea prepolymer intermediate, that is capable of forming a polyurethane-polyurea hydrogel-forming polymer, and that contains terminal isocyanate groups that are free to react with other species, such that at least some of said terminal isocyanate groups are reacted with and are covalently bonded to said reactive chemical functional groups on said substrate surface, forming covalent polyurea bonds therewith, resulting in the formation of a tie coat of a polyurethane-polyurea hydrogel-forming polymer, on said substrate surface, such that said polyurethane-polyurea hydrogel-forming polymer tenaciously adheres to said substrate surface; andwherein at least some of said terminal isocyanate groups of said polyurethane-urea prepolymer intermediate are present in said polyurethane-polyurea hydrogel-forming polymer such that they remain free to react with other species; andc) a second coating, applied onto said tie coat, said second coating being an aqueous solution of a poly(N-vinylpyrrolidone) hydrogel-forming polymer, such that a barrier coat which is a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel is formedwherein water of said aqueous solution of said poly(N-vinylpyrrolidone) hydrogel-forming polymer is bound with said polyurethane-polyurea hydrogel-forming polymer to form a polyurethane-polyurea polymer hydrogel;wherein water of said aqueous solution of said poly(N-vinylpyrrolidone hydrogel-forming polymer is bound with said poly(N-vinylpyrrolidone) hydrogel-forming polymer to form a poly(N-vinylpyrrolidone polymer hydrogel; andwherein said poly(N-vinylpyrrolidone polymer hydrogel is adherent to said substrate surface as a result of being commingled with said polyurethane-polyurea polymer hydrogel.
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