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Methods of dehydrating, storing and rehydrating liposomes

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-091/27
  • B01J-013/02
  • B01J-013/04
출원번호 US-0876938 (1997-06-16)
발명자 / 주소
  • Janoff Andrew S.
  • Cullis Pieter R.,CAX
  • Bally Marcel B.,CAX
  • Fountain Michael W.
  • Ginsberg Richard S.
  • Hope Michael J.,CAX
  • Madden Thomas D.,CAX
  • Schieren Hugh P.
  • Jablonski Regina L.
출원인 / 주소
  • The Liposome Company, Inc.
대리인 / 주소
    Rubin
인용정보 피인용 횟수 : 44  인용 특허 : 25

초록

Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides trehalose and sucrose. Preferably, the protective sugars are present at both the inside and outside surfaces of the liposome membranes. F

대표청구항

[ What is claimed is:] [1.] A method for loading liposomes with a charged material comprising the steps of:(a) preparing a liposome preparation which includes liposomes having an ion concentration gradient capable of generating a transmembrane potential having an orientation which will load the char

이 특허에 인용된 특허 (25)

  1. Tsang Wen-Ghih (Lexington MA), Capsule loading technique.
  2. Bally Marcel B. (Vancouver CAX) Loughrey Helen (Vancouver CAX) Cullis Pieter R. (Vancouver CAX), Composition for targeting, storing and loading of liposomes.
  3. Vanlerberghe Guy (Commune de Villevaude FRX) Handjani Rose-Marie (Paris FRX), Compositions containing aqueous dispersions of lipid spheres.
  4. Carpenter John F. (Davis CA) Hand Steven C. (Lafayette LA) Crowe John H. (Davis CA) Crowe Lois M. (Davis CA), Cryogenic protectant for proteins.
  5. Janoff Andrew S. (Yardley PA) Cullis Pieter R. (Vancouver CAX) Bally Marcel B. (Vancouver NJ CAX) Fountain Michael W. (Griggstown NJ) Ginsberg Richard S. (Monroe NJ) Hope Michael J. (Vancouver CAX) M, Dehydrated liposomes.
  6. Allison Anthony Clifford (London EN) Gregoriadis Gregory (Kenton EN), Immunological preparations.
  7. Ullman Edwin F. (Atherton CA) Brinkley John M. (Oakland CA), Labeled liposome particle compositions and immunoassays therewith.
  8. Fountain Michael W. (Plainsboro NJ) Weiss Steven J. (Heightstown NJ) Popescu Mircea C. (Plainsboro NJ), Lipid vesicles prepared in a monophase.
  9. Deamer David W. (Woodland CA), Method for encapsulating materials into liposomes.
  10. Crowe John H. (Davis CA) Crowe Lois M. (Davis CA), Method for preserving liposomes.
  11. Furuno Kouji (Kokubunji JA) Okazaki Akira (Oyama JA) Matsubara Syuzo (Fuchu JA) Shiba Motoharu (Omiya JA) Shioya Akitoshi (Kawagoe JA), Method for reducing side effects of aminoglycoside antibiotics and composition therefor.
  12. Papahadjopoulos Demetrios P. (78 Heathwood Williamsville NY 14221) Szoka ; Jr. Francis C. (375 Leroy Ave. Buffalo NY 14214), Method of encapsulating biologically active materials in lipid vesicles.
  13. Papahadjopoulos Demetrios P. (78 Heathwood Williamsville NY 14221) Szoka ; Jr. Francis C. (375 Leroy Ave. Buffalo NY 14214), Method of encapsulating biologically active materials in lipid vesicles.
  14. Mezei Michael (Halifax CAX) Nugent Fredric J. (Halifax CAX), Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV).
  15. Suzuki Akira (Takatsuki JA) Miura Hiroshi (Neyagawa JA) Matsuda Saburo (Kyoto JA) Ohsawa Takashi (Ibaragi JA), Method of preparing a controlled release liquid pharmaceutical composition.
  16. Tice Thomas R. (Helena AL) Lewis Danny H. (Gardendale AL), Microencapsulation process.
  17. Moro Luigi (Cairate ITX) Neri Guido (Milan ITX) Rigamonti Alessandro (Milan ITX), Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same.
  18. Schrank Jrg (Riehen CHX) Steffen Hans (Arisdorf CHX), Pharmaceutical preparations.
  19. Weder Hans G. (E. Merck ; Postfach 4119 6100 Darmstadt 1 DEX) Zumbhl Otmar (Wolfenshiessen CHX) Schwendener Reto (Arosa CHX) Milsmann Manfred (Bielefeld DEX), Process and device for producing bilayer vesicles.
  20. Evans John R. (Macclesfield GB2) Fildes Francis J. T. (Macclesfield GB2) Oliver Jean E. (Macclesfield GB2), Process for preparing freeze-dried liposome compositions.
  21. Evans John R. (Macclesfield GB2) Fildes Francis J. T. (Macclesfield GB2) Oliver Jean E. (Macclesfield GB2), Process for preparing freeze-dried liposome compositions.
  22. Schneider Michel (Grand-Lancy CHX) Lamy Bernard (Carouge CHX), Process for the dehydration of a colloidal dispersion of lipsomes.
  23. Lenk Robert P. (Lambertville NJ) Fountain Michael W. (Plainsboro NJ) Janoff Andrew S. (Lawrenceville NJ) Ostro Marc J. (North Brunswick NJ) Popescu Micrea C. (Plainsboro NJ), Stable plurilamellar vesicles, their preparation and use.
  24. Weiner Murray (8915 Spooky Ridge La. Cincinnati OH 45242) Gersonde Klaus (Preusweg 69 D-5100 Aachen DEX), Storage-stable lipid vesicles and method of preparation.
  25. Regen Steven L. (Milwaukee WI), Synthetic phosphatidyl cholines useful in forming liposomes.

이 특허를 인용한 특허 (44)

  1. Peer, Dan, Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof.
  2. Drummond, Daryl C.; Kirpotin, Dmitri B.; Wickham, Thomas; Hendriks, Bart S.; Agresta, Samuel; Lee, Helen; Gaddy, Daniel F., Compositions and methods for non-invasive imaging.
  3. Drummond, Daryl C.; Kirpotin, Dmitri B.; Wickham, Thomas; Hendriks, Bart S.; Agresta, Samuel; Lee, Helen; Gaddy, Daniel F., Compositions and methods for non-invasive imaging.
  4. Davidsen, Jesper; Andersen, Peter; Rosenkrands, Ida, Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids.
  5. Davidsen, Jesper; Andersen, Peter; Rosenkrands, Ida, Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids.
  6. Malinin, Vladimir, Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods of use thereof.
  7. Durst, Richard A.; Martorell-Pena, Daniel; Siebert, Sui Ti Atienza, Dehydration/rehydration of derivatized, marker-loaded liposomes on a test device and method of use thereof.
  8. Singer, Nicholas J., Delivery system for drinks.
  9. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  10. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  11. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  12. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  13. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  14. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  15. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  16. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  17. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  18. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  19. Margalit, Rimona; Peer, Dan, Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy.
  20. Margalit, Rimona; Peer, Dan, Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy.
  21. Peer, Dan; Alpert, Evgenia, Lipidated glycosaminoglycan particles for the delivery of nucleic acids.
  22. Cullis, Pieter R; Madden, Thomas D; Hope, Michael J; Ansell, Steven M; Mui, Barbara L S; Semple, Sean C; Maurer, Norbert, Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof.
  23. Gupta, Renu, Method for treating pulmonary disorders with liposomal amikacin formulations.
  24. Stillman, Suzanne Jaffe, Method of hydration; infusion packet system(s), support member(s), delivery system(s), and method(s); with business model(s) and Method(s).
  25. Durst,Richard A.; Martorell Pena,Daniel; Siebert,Sui Ti Atienza, Method of making a test device.
  26. Gupta, Renu, Method of treating pulmonary disorders with liposomal amikacin formulations.
  27. Gupta, Renu, Method of treating pulmonary disorders with liposomal amikacin formulations.
  28. Eagle, Gina; Gupta, Renu, Methods for treating pulmonary non-tuberculous mycobacterial infections.
  29. Eagle, Gina; Gupta, Renu, Methods for treating pulmonary non-tuberculous mycobacterial infections.
  30. Eagle, Gina; Gupta, Renu, Methods for treating pulmonary non-tuberculous mycobacterial infections.
  31. Gupta, Renu, Methods of treating pulmonary disorders with liposomal amikacin formulations.
  32. Gupta, Renu, Methods of treating pulmonary disorders with liposomal amikacin formulations.
  33. Gupta, Renu, Methods of treating pulmonary disorders with liposomal amikacin formulations.
  34. Stillman,Suzanne Jaffe, Nutritionally fortified liquid composition with added value delivery systems/elements/additives.
  35. Singer, Nicholas J., Package.
  36. Singer, Nicholas J., Package.
  37. Perkins, Walter; Malinin, Vladimir, Stabilized vancomycin formulations.
  38. Boni, Lawrence T.; Miller, Brian S.; Malinin, Vladimir; Li, Xingong, Sustained release of antiinfectives.
  39. Boni, Lawrence T.; Miller, Brian S.; Malinin, Vladimir; Li, Xingong, Sustained release of antiinfectives.
  40. Perkins, Walter; Malinin, Vladimir; Li, Xingong; Miller, Brian; Seidel, Dominique; Holzmann, Philipp; Schulz, Harald; Hahn, Michael, Systems for treating pulmonary infections.
  41. Stillman, Suzanne Jaffe, Water containing soluble fiber.
  42. Stillman, Suzanne Jaffe, Water containing soluble fiber.
  43. Stillman, Suzanne Jaffe, Water containing soluble fiber.
  44. Stillman, Suzanne Jaffe, Water containing soluble fiber.
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