IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0875106
(1997-09-29)
|
우선권정보 |
FR-0000757 (1995-01-24) |
국제출원번호 |
PCT/FR96/00114
(1996-01-24)
|
§371/§102 date |
19970929
(19970929)
|
국제공개번호 |
WO-9622808
(1996-08-01)
|
발명자
/ 주소 |
- Muller Daniel,FRX
- Barbier Alain,FRX
- Saunal Henry,FRX
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
50 인용 특허 :
4 |
초록
▼
A device comprising a reversible negative electrode in contact with a reservoir element containing an electrolyte which contains an active principle such as an anionic oligosaccharide, particularly a pentasaccharide, in at least partially ionised form, a positive electrode alone or in combination wi
A device comprising a reversible negative electrode in contact with a reservoir element containing an electrolyte which contains an active principle such as an anionic oligosaccharide, particularly a pentasaccharide, in at least partially ionised form, a positive electrode alone or in combination with an electrolyte-containing receptacle, and an electrical signal generator connectable to both electrodes. The generator is arranged to apply electrical signals between the electrodes, which signals have an average voltage such that the average current density generated between the electrodes is 0.05-0.25 mA/cm.sup.2. The amount of active principle in the reservoir element combined with the negative electrode is 0.5-12 mg per cm.sup.2. The amount of active principle in the reservoir element combined with the negative electrode is 0.5-12 mg per cm.sup.2 and per mAh of current through 1 cm.sup.2 of the electrode.
대표청구항
▼
[ We claim:] [1.] Iontophoresis device for transcutaneous administration of a medicament active principle of the anionic type, comprising a negative electrode assembly consisting of a negative electrode, referred to as the active electrode, in contact with a reservoir element containing an electroly
[ We claim:] [1.] Iontophoresis device for transcutaneous administration of a medicament active principle of the anionic type, comprising a negative electrode assembly consisting of a negative electrode, referred to as the active electrode, in contact with a reservoir element containing an electrolyte holding the active principle in an at least partially ionized form, the said reservoir element being arranged in order to ensure, when it is placed in contact with an area of the subject's skin, ionic conducting continuity between the said negative electrode and the said area, a positive electrode assembly consisting either (i) of a positive electrode alone, or preferably (ii) of a positive electrode in contact with a receptacle element containing at least one electrolyte, the said receptacle element being arranged in order to ensure, when it is placed in contact with a portion of the subject's skin, ionic conducting continuity between the positive electrode and the said portion, and an electrical signal generator which can be connected to the two electrodes, the negative electrode in contact with the reservoir element being formed at least in part by an ionizable metal compound, the metal ions of which are capable of being electrochemically reduced to the corresponding metal and of forming an electrochemically reversible system with the said metal, so as to constitute a reversible negative electrode, at least when the device is operating, and the generator being arranged in order to apply electrical signals between the electrodes, with an average voltage such that the average current density generated between the said electrodes is between 0.03 and 0.5 mA/cm.sup.2, which device is characterized in that the active principle present in the reservoir element associated with the negative electrode is chosen from the anionic oligosaccharides represented by the alkali metal or alkaline-earth metal salts of oligosaccharides which consist of from two to twelve saccharide units, of which some or all of the units have their OH groups replaced, at least in part, by functional groups chosen from --OSO.sub.3.sup.-, --COO.sup.-, --NHSO.sub.3.sup.-, --NH-acyl, --OPO.sub.3.sup.-- and --OT, T representing a hydrocarbon radical, and which have an ionic nature suitable for iontophoretic administration, and in that the said current density has values ranging from 0.05 mA/cm.sup.2 to 0.25 mA/cm.sup.2, and in that the quantity of active principle initially present in the reservoir element associated with the negative electrode represents from 0.5 to 12 mg per cm.sup.2 of electrode and per mAh of current flowing per cm.sup.2 of electrode.
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