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특허 상세정보

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High concentration white cells, a method for agglomeration of the high concentration and a bag set for use in conjuncti

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61B-019/00    B01D-033/15   
미국특허분류(USC) 604/410 ; 604/406 ; 210/206 ; 210/782 ; 210/787 ; 210/806
출원번호 US-0128208 (1998-08-03)
발명자 / 주소
  • Rubinstein Pablo
  • Coelho Philip Henry
  • Stevens Cladd E.
출원인 / 주소
  • New York Blood Center, Inc.
대리인 / 주소
    Amster, Rothstein & Ebenstein
인용정보 피인용 횟수 : 88  인용 특허 : 9
초록

A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.

대표
청구항
▼

[ I claim:] [1.] A system for concentrating blood cells, comprising:a first bag for containing blood and an anticoagulant,a container, removably coupled to said first bag through a coupling system, for containing a red blood cell sedimentation reagent,a second bag removably coupled to said first bag through a coupling system for receiving from said first bag a first supernatant containing at least 80% of white blood cells contained in said first bag after said blood is mixed with said red blood cell sedimentation reagent, and after said first bag is cent...

인용문헌 (9)

  1. Shiraki Hiroshi (Chikushino JPX) Yamamoto Kiyoko (Chikushino JPX) Kitagawa Akiko (Mito JPX) Kawaoka Tatsuhiko (Fujinomiya JPX) Oonaka Yukihiro (Fuji JPX), Apparatus for separation of blood components.
  2. Joie Michel,BEX ; Debrauwere Jack,BEX ; Bernes Jean-Claude,BEX ; Goldhaber Richard, Blood collection container.
  3. Beshel Richard, Closed system and methods for mixing additive solutions while removing undesired matter from blood cells.
  4. Carmen Raleigh A. ; Chong Chi Yong ; Garcez Randy B., Long-term blood components storage system and method.
  5. Rubinstein Pablo ; Coelho Philip Henry ; Stevens Cladd E., Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulate.
  6. Joie Michel (Ernage BEX) Debrauwere Jack (Halle BEX) Bernes Jean-Claude (Faimes BEX), Method for storing blood in a container having multiple chambers.
  7. Tanokura Nobukazu (Shizuoka JPX) Ohnaka Yukihiro (Shizuoka JPX) Ishida Noboru (Shizuoka JPX), Method for treatment of blood using a blood bag.
  8. Carmen Raleigh A. (Concord CA) Nelson Edward J. (San Rafael CA), Pre-storage filtration of platelets.
  9. Goldhaber Richard (Lake Forest IL) Bischof Daniel F. (McHenry IL), Systems and methods for removing undesired matter from blood cells.

이 특허를 인용한 특허 (88)

  1. Felt, Thomas; Pihlstedt, Peter; Gibbs, Bruce, Adjusting pH in a method of separating whole blood.
  2. Abbot, Stewart; Edinger, James W.; Francki, Aleksandar; Kaplunovsky, Aleksandr; Jankovic, Vladimir; Labazzo, Kristen; Law, Eric; Padliya, Neerav D.; Paredes, Jennifer; Wang, Jia-Lun, Amnion derived adherent cells.
  3. Abbot, Stewart; Edinger, James W.; Francki, Aleksandar; Kaplunovsky, Aleksandr; Jankovic, Vladimir; Labazzo, Kristen; Law, Eric; Padliya, Neerav; Paredes, Jennifer; Wang, Jia-Lun, Amnion derived adherent cells.
  4. Abbot, Stewart; Edinger, James W.; Francki, Aleksandar; Hariri, Robert J.; Jankovic, Vladimir; Kaplunovsky, Aleksandr; Labazzo, Kristen; Law, Eric; Padliya, Neerav D.; Paredes, Jennifer; Wang, Jia-Lun, Angiogenesis using placental stem cells.
  5. Lampeter, Eberhard; Egger, Dietmar, Bag system for the cryopreservation of body fluids.
  6. Mathias,Jean Marie; Rondeau,Georges; Joie,Michel, Biological fluid sampling apparatus, assembly and method.
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  8. Heidaran, Mohammad; Wang, Jia-Lun; Ye, Qian; Zeitlin, Andrew; Delaney, Colleen Suzanne, Co-culture of placental stem cells and stem cells from a second source.
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  11. Harmon, Alexander M.; Ang, Abel, Conditioned media and methods of making a conditioned media.
  12. Mathias Jean-Marie,BEX ; Payrat Jean-Marc,BEX ; Coneys Thomas,FRX ; Van Heems Philippe,FRX, Confined air tube and methods for handling air in closed blood processing systems.
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  14. Mathias, Jean-Marie; Bernes, Jean-Claude, Container for receiving a blood sample.
  15. Hariri, Robert J., Cytotherapeutics, cytotherapeutic units and methods for treatments using them.
  16. McKenna, Jr., David H.; Tigges, Barbara M.; Berger, Michael J., Differentiation of multi-lineage progenitor cells to respiratory epithelial cells.
  17. Hariri,Robert J., Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells.
  18. Abbot, Stewart; Karasiewicz-Mendez, Kathy E.; Voskinarian-Berse, Vanessa; Zhang, Xiaokui, Enhancement of placental stem cell potency using modulatory RNA molecules.
  19. Rubinstein,Pablo; Coelho,Philip Henry; Stevens,Cladd E., High concentration white blood cells as a therapeutic product.
  20. Medin, Jeffrey A.; Paige, Christopher J., IL-12 immunotherapy for cancer.
  21. Medin, Jeffrey A.; Paige, Christopher J., IL-12 immunotherapy for cancer.
  22. Medin, Jeffrey A.; Paige, Christopher J., IL-12 immunotherapy for cancer.
  23. Paludan, Casper; Edinger, James W.; Harbacheuski, Ryhor; Murray, RoseAnn; Hariri, Robert J., Immunomodulation using placental stem cells.
  24. Paludan, Casper; Edinger, James; Harbacheuski, Ryhor; Murray, RoseAnn; Hariri, Robert J., Immunomodulation using placental stem cells.
  25. Paludan, Casper; Edinger, James; Harbacheuski, Ryhor; Murray, RoseAnn; Hariri, Robert J., Immunomodulation using placental stem cells.
  26. Hariri, Robert J., Isolated placental perfusate and placental cells isolated therefrom.
  27. Foucaut, Bertrand Marcel Alexandre; Fell, Claude, Manufacture of bags for containing biological specimens.
  28. Mathias, Jean-Marie; Blickhan, Bryan; Haldiman, Stephanie; Servi, Jr., Larry; Bernes, Jean-Claude; Bischof, Daniel F., Method and apparatus for blood sampling.
  29. Mathias,Jean Marie; Bernes,Jean Claude; Coneys,Thomas Walter, Method and apparatus for collecting blood samples prior to a blood collection procedure.
  30. Mishra, Allan, Method of administration of platelet-rich plasma to treat an acute cardiac dysfunction.
  31. Hariri, Robert J., Method of collecting placental stem cells.
  32. Hariri,Robert J., Method of collecting placental stem cells.
  33. Mishra, Allan, Method of preparing neutrophil-depleted platelet-rich plasma.
  34. Heidaran, Mohammad A.; Zhang, Xiaokui; Kang, Lin; Zeitlin, Andrew; Voskinarian-Berse, Vanessa R.; Abbott, Stewart Ernest, Method of producing erythrocytes.
  35. Abbot, Stewart; Kang, Lin; Voskinarian-Berse, Vanessa; Zhang, Xiaokui, Method of producing erythrocytes without feeder cells.
  36. Abbot, Stewart; Kang, Lin; Voskinarian-Berse, Vanessa; Zhang, Xiaokui, Method of producing erythrocytes without feeder cells.
  37. Hariri, Robert J., Method of propagating cells.
  38. Chow, Robert, Method of treating a hematopoietic associated disease or disorder with plasma-depleted, but not erythrocyte-depleted cord blood compositions.
  39. Abramson, Sascha D.; Guelakis, Marian; Heidaran, Mohammad A.; Labazzo, Kristen; Yaccoby, Shmuel, Methods and compositions for treatment of bone defects with placental cell populations.
  40. Hariri, Robert J.; Heidaran, Mohammad A.; Jasko, Stephen; Kang, Lin; Law, Eric; Pal, Ajai; Stout, Bhavani; Voskinarian-Berse, Vanessa; Zeitlin, Andrew; Zhang, Xiaokui, Methods of generating natural killer cells.
  41. Hariri, Robert J.; Heidaran, Mohammad A.; Jasko, Stephen; Kang, Lin; Law, Eric; Pal, Ajai; Stout, Bhavani; Voskinarian-Berse, Vanessa; Zeitlin, Andrew; Zhang, Xiaokui, Methods of generating natural killer cells.
  42. Collins, Daniel P.; Sprague, Stacey L.; Tigges, Barbara M., Multi-lineage progenitor cells.
  43. Collins, Daniel P.; Sprague, Stacey L.; Tigges, Barbara M., Multi-lineage progenitor cells.
  44. Collins, Daniel P.; Sprague, Stacey L.; Tigges, Barbara M., Multi-lineage progenitor cells.
  45. Zhang, Xiaokui; Hariri, Robert J.; Voskinarian-Berse, Vanessa; Kang, Lin; Law, Eric; Abbot, Stewart, Natural killer cells from placenta.
  46. Mishra, Allan, Neutrophil-depleted platelet rich plasma formulations for cardiac treatments.
  47. Edinger, James; Ye, Qian; Wang, Jai-Lun; Hariri, Robert J., Placental stem cell populations.
  48. Edinger, James; Ye, Qian; Wang, Jai-Lun; Hariri, Robert J., Placental stem cell populations.
  49. Edinger, James; Ye, Qian; Wang, Jai-Lun; Hariri, Robert J., Placental stem cell populations.
  50. Edinger, James; Ye, Qian; Wang, Jai-Lun; Hariri, Robert J., Placental stem cell populations.
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  55. Chow, Robert, Plasma-depleted, not erythrocyte-depleted, cord blood compositions and method of making.
  56. Mishra, Allan Kumar, Platelet rich plasma formulations for cardiac treatments.
  57. Mishra, Allan, Platelet-rich plasma compositions and methods of preparation.
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  64. Brown, Laura J.; Harmon, Alexander M.; Gosiewska, Anna, Soft tissue repair and regeneration using postpartum-derived cells and cell products.
  65. Brown, Laura; Harmon, Alexander M.; Gosiewska, Anna, Soft tissue repair and regeneration using postpartum-derived cells and cell products.
  66. Lampeter, Eberhard F., Sterile system and methods for collecting, transporting, storing and cyropreserving body fluids.
  67. Mathias, Jean Marie; Blom, Agneta; Mespreuve, Luc; Vandendaul, Daniel; Payrat, Jean-Marc, Systems and methods for collecting plasma that is free or virtually free of cellular blood species.
  68. Medin, Jeffrey A.; Devine, Sean, Thymidylate kinase fusions and uses thereof.
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  71. Hariri, Robert J.; Gurney, Jodi P., Treatment of amyotrophic lateral sclerosis using placental stem cells.
  72. Zhang, Xiaokui; Yaccoby, Shmuel; Abramson, Sascha; Hariri, Robert J., Treatment of bone-related cancers using placental stem cells.
  73. Hariri, Robert J., Treatment of diseases or disorders using placental stem cells.
  74. Edinger, James W.; Hariri, Robert J.; Wang, Jia-Lun; Ye, Qian; Faleck, Herbert, Treatment of inflammatory diseases using placental stem cells.
  75. Edinger, James W.; Hariri, Robert J.; Wang, Jia-Lun; Ye, Qian; Faleck, Herbert, Treatment of inflammatory diseases using placental stem cells.
  76. Paludan, Casper; Edinger, James W.; Harbacheuski, Ryhor; Murray, RoseAnn; Hariri, Robert J., Treatment of multiple sclerosis using placental stem cells.
  77. Seyda, Agnieszka; Gosiewska, Anna, Treatment of neurological injury by administration of human umbilical cord tissue-derived cells.
  78. Hariri, Robert J., Treatment of organ injuries and burns using placental stem cells.
  79. Herzberg, Uri; Gurney, Jodi P., Treatment of pain using placental stem cells.
  80. Edinger, James W.; Hariri, Robert J.; Wang, Jia-Lun; Ye, Qian; Faleck, Herbert, Treatment of psoriasis using placental stem cells.
  81. Hariri, Robert J., Treatment of radiation injury using placental stem cells.
  82. Edinger, James W.; Fischkoff, Steven Alan; Francki, Aleksandar; Jankovic, Vladimir; Liang, Bitao; Martin, Philippe; Ray, Cynthia; Zhang, Xiaokui, Treatment of sarcoidosis using placental stem cells.
  83. Zeitlin, Andy; Pal, Ajai, Treatment of stroke using isolated placental cells.
  84. Hariri, Robert J., Treatment of stroke using placental stem cells.
  85. Hariri, Robert J.; Heidaran, Mohammad A.; Kang, Lin; Padliya, Neerav Dilip; Pal, Ajai; Voskinarian-Berse, Vanessa; Zeitlin, Andrew; Zhang, Xiaokui, Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells.
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  87. Mishra, Allan Kumar; Brinton, Todd Jeffrey, Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities.
  88. Kihm, Anthony J.; Gosiewska, Anna, hUTC as therapy for Alzheimer's disease.

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