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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0443383 (1995-05-17) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 573 인용 특허 : 5 |
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure [ STR 1 ] wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms poly.sub.a
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure [ STR 1 ] wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms poly.sub.a and poly.sub.b, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings and ester groups in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure [ STR 2 ] where mPEG.sub.a and mPEG.sub.b have the structure CH.sub.3 O--(CH.sub.2 CH.sub.2 O).sub.n CH.sub.2 CH.sub.2 -- wherein n may be the same or different for mPEG.sub.a and mPEG.sub.b and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000. The mPEG disubstituted lysine can be purified from a reaction mixture by chromatography in water, including gel filtration chromatography and ion exchange chromatography because the carboxyl group is ionizable. Impurities are removed, including unreacted mPEG and mPEG monosubstituted lysine, to provide the polymer in pure form. Ion exchange chromatography permits fractionation of a greater amount of polymer per run.
[ What is claimed is:] [1.] An essentially pure water soluble polymer having a moiety located along the polymer backbone, which moiety comprises a single ionizable reactive group, wherein said polymer is represented by the structure: [ STR 30 ] wherein C is carbon; wherein R is a nonreactive moiety;
[ What is claimed is:] [1.] An essentially pure water soluble polymer having a moiety located along the polymer backbone, which moiety comprises a single ionizable reactive group, wherein said polymer is represented by the structure: [ STR 30 ] wherein C is carbon; wherein R is a nonreactive moiety; wherein Z is said moiety comprising a single ionizable reactive group; wherein poly.sub.a and poly.sub.b are nonpeptidic and nonreactive polymeric arms that may be the game or different; wherein P and Q are nonreactive linkage fragments that may be the same or different and join polymeric arms poly.sub.a and poly.sub.b, respectively, to C in the absence of aromatic rings and ester groups in said fragments, and wherein said polymer is recovered in essentially pure form by ion exchange chromatography.
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