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Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-043/04
출원번호 US-0657238 (1996-06-03)
발명자 / 주소
  • Fasbender Allen J.
  • Welsh Michael J.
  • Siegel Craig S.
  • Lee Edward R.
  • Chang Chau-Dung
  • Marshall John
  • Cheng Seng H.
  • Harris David J.
  • Eastman Simon J.
  • Hubbard Shirley C.
  • Lane Mathieu B.
출원인 / 주소
  • University of Iowa
대리인 / 주소
    Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
인용정보 피인용 횟수 : 47  인용 특허 : 12

초록 ▼

Novel compositions are provided. Typically, the compositions comprise one or more neutral co-lipids and also a cationic amphiphile. Therapeutic compositions are prepared according to the practice of the invention by contacting a therapeutically active molecule with a dispersion of neutral co-lipid(s

대표청구항 ▼

[ We claim:] [1.] A composition comprising a solid or liquid dispersion of:(A) a cationic amphiphile according to the formula [ STR 13 ] wherein: each of x, x', y, and y' is a whole number other than 0 or 1, except that, optionally, the entire [NH(CH.sub.2).sub.y '] can be absent;R.sup.3 and R.sup.4

이 특허에 인용된 특허 (12)

  1. Huang Leaf (Knoxville TN) Liu Dexi (Knoxville TN), Blood-stable, cholesterol-free liposomes.
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  2. Gebeyehu Gulilat (Silver Spring MD) Jessee Joel A. (Mt. Airey MD) Ciccarone Valentina C. (Gaithersburg MD) Hawley-Nelson Pamela (Silver Spring MD) Chytil Anna (Nashville TN), Cationic lipids.
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  3. Felgner, Philip L.; Kumar, Raj; Basava, Channa; Border, Richard C.; Hwang-Felgner, Jiin-Yu, Cationic lipids for intracellular delivery of biologically active molecules.
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  4. Letsinger Robert L. (Wilmette IL), Cholesteryl modified oligonucleotides.
    상세보기
  5. Li Ming P. (Pasadena CA) Baldeschwieler John D. (Pasadena CA), Lamellar vesicles formed of cholesterol derivatives.
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  6. Behr Jean-Paul (Strasbourg FRX) Loeffler Jean-Philippe (Strasbourg FRX), Lipopolyamines, their preparation and their use.
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  7. Ryan, Patrick J.; Davis, Michael A.; Melchior, Donald L., Liposomes containing modified cholesterol for organ targeting.
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  8. Epand Richard M. (Hamilton CAX) Bottega Remo (Ancaster,both of PA CAX) Huang Leaf (Upper St. Claim PA), Method for delivering nucleic acids into cells.
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  9. Szoka ; Jr. Francis C. (76 Summit St. Waltham MA 02154) Papahadjopoulos Demetrios P. (3170 Condit St. Lafayette CA 94549), Method of inserting DNA into living cells.
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  10. Eppstein Deborah A. (Menlo Park CA) Felgner Philip L. (Los Altos CA) Gadek Thomas R. (Oakland CA) Jones Gordon H. (Cupertino CA) Roman Richard B. (Fairhope AL), N[www 상세보기
  • Kim Young D. (Seoul KRX) Ha Byung J. (Seoul KRX), Quaternary ammonium-substituted sterol derivatives.
    상세보기
  • Letsinger Robert L. (Wilmetter IL), Steroid modified oligonucleotides.
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    • 이 특허를 인용한 특허 (47)

    1. Quay, Steven C.; Houston, Jr., Michael E.; Harvie, Pierrot; Adami, Roger C.; Fam, Renata; Prieve, Mary G.; Fosnaugh, Kathy L.; Seth, Shaguna, Amino acid lipids and uses thereof.
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    2. Quay, Steven C.; Houston, Jr., Michael E.; Harvie, Pierrot; Adami, Roger C.; Fam, Renata; Prieve, Mary G.; Fosnaugh, Kathy L.; Seth, Shaguna, Amino acid lipids and uses thereof.
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    3. Nishizaki, Tomoyuki; Nakano, Takashi, Anti-cancer agent containing a diacylphosphatidylethanolamine as an active ingredient.
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    4. Quay, Steven C.; Houston, Jr., Michael E.; Harvie, Pierrot; Adami, Roger C.; Fam, Renata; Prieve, Mary G.; Fosnaugh, Kathy L.; Seth, Shaguna, Arginine-based lipids for delivery of therapeutics.
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    5. Kiser, Patrick F.; Thomas, Allen A., Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments.
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    6. Innis, Michael A.; Reinhard, Christoph J.; Zuckermann, Ronald N., Chimeric antisense oligonucleotides and cell transfecting formulations thereof.
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    7. Meeker, David; Cheng, Seng H., Combination enzyme replacement and small molecule therapy for treatment of lysosomal storage diseases.
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    8. de Mollerat du Jeu, Xavier; Andronikou, Nektaria, Compositions and methods for efficient delivery of molecules to cells.
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    9. Ciccarone, Valentina C.; Gruber, Dale; Bennett, Shelly, Culture medium for cell growth and transfection.
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    10. Kuliopulos, Athan; Covic, Lidija, G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same.
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    11. Kuliopulos, Athan; Covic, Lidija, G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same.
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    12. Kuliopulos, Athan; Covic, Lidija; Kaneider, Nicole, G protein coupled receptor agonists and antagonists and methods of use.
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    13. Kuliopulos, Athan; Covic, Lidija, G protein coupled receptor antagonists and methods of activating and inhibiting G protein coupled receptors using the same.
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    14. Haces, Alberto; Ciccarone, Valentina C., Highly packed polycationic ammonium, sulfonium and phosphonium lipids.
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    15. Haces,Alberto; Ciccarone,Valentina C., Highly-packed polycationic ammonium, sulfonium and phosphonium lipids.
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    16. Furgeson, Darin Y.; Kim, Sung Wan, Linear polyethylenimine-sterol conjugates for gene delivery.
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    17. Furgeson,Darin Y.; Kim,Sung Wan, Linear polyethylenimine-sterol conjugates for gene delivery.
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    18. Pachuk, Catherine J., Methods and compositions for silencing genes without inducing toxicity.
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    19. Kuliopulos, Athan; Covic, Lidija, Methods of activating or inhibiting G protein coupled receptors (GPCRs).
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    20. Boutin Raymond H., Multifunctional complexes for gene transfer into cells comprising a nucleic acid bound to a polyamine and having a endosome disruption agent.
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    21. Raymond H. Boutin, Multifunctional complexes for gene transfer into cells comprising a nucleic acid bound to a polyamine and having an endosome disruption agent.
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    22. Boutin,Raymond H., Multifunctional molecular complexes for gene transfer to cells.
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    23. Zuckermann,Ronald N.; Reinhard,Christoph J.; Jefferson,Anne B; Beausoleil,Eric, Oligonucleotide transfection screening method.
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    24. Avila, Luis Z.; Pan, Clark Q.; Finn, Patrick; Harrahy, John; Zhou, Qun; Zhu, Yunxiang; Konowicz, Paul A.; Paterson, Duncan E.; Peer, Andreas; Kutzko, Joseph P.; Reardon, Michael R.; Stefano, James E.; Zheng, Xiaoyang; Miller, Robert J.; Young, Lauren, Oligosaccharide-protein conjugates.
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    25. Avila, Luis Z.; Pan, Clark Q.; Finn, Patrick; Harrahy, John; Zhou, Qun; Zhu, Yunxiang; Konowicz, Paul A.; Paterson, Duncan E.; Peer, Andreas; Kutzko, Joseph P.; Reardon, Michael R.; Stefano, James E.; Zheng, Xiaoyang; Miller, Robert J.; Young, Lauren, Oligosaccharide-protein conjugates.
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    26. Gebeyehu, Guililat; Jessee, Joel A., Reagents for intracellular delivery of macromolecules.
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    27. Gebeyehu,Gulilat; Jessee,Joel A., Reagents for intracellular delivery of macromolecules.
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    28. Berndl, Gunther; Breitenbach, Jörg; Heger, Robert; Stadler, Michael; Wilke, Peter; Rosenberg, Jörg, Self-emulsifying active substance formulation and use of this formulation.
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    29. Rosenberg, Jeorg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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    30. Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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    31. Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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    32. Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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    33. Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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    34. Rosenberg, Jöerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Jörg; Alani, Laman L.; Ghosh, Soumojeet, Solid pharmaceutical dosage formulation.
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    35. Weiner, David B.; Muthumani, Karuppiah; Zhang, Donghui; Ramanathan, Mathura P., Targeted particles and methods of using the same.
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    36. Weiner, David B; Muthumani, Karuppiah; Zhang, Donghui; Ramanathan, Mathura, Targeted particles and methods of using the same.
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    37. Chu, Yongliang; Masoud, Malek; Gebeyehu, Gulilat, Transfection reagents.
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    38. Chu, Yongliang; Masoud, Malek; Gebeyehu, Gulilat, Transfection reagents.
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    39. Chu, Yongliang; Masoud, Malek; Gebeyehu, Gulilat, Transfection reagents.
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    40. Chu, Yongliang; Masoud, Malek; Gebeyehu, Gulilat, Transfection reagents.
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    41. Chu,Yongliang; Masoud,Malek; Gebeyehu,Gulilat, Transfection reagents.
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    42. Chu,Yongliang; Masoud,Malek; Gebeyehu,Gulilat, Transfection reagents.
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    43. Chu,Yongliang; Masoud,Malek; Gebeyehu,Gulilat, Transfection reagents.
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    44. Chu,Yongliang; Masoud,Malek; Gebeyehu,Gulilat, Transfection reagents.
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    45. Chu,Yongliang; Masoud,Malek; Gebeyehu,Gulilat, Transfection reagents.
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    46. Chu,Yongliang; Masoud,Malek; Gebeyehu,Gulilat, Transfection reagents.
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    47. Quay, Steven C.; Houston, Jr., Michael E.; Harvie, Pierrot; Adami, Roger C.; Fam, Renata; Prieve, Mary; Fosnaugh, Kathy; Seth, Shaguna, Tyrosine-based lipids for delivery of therapeutics.
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