초록

Dosage forms for the transdermal administration of apomorphine are described. The dosage forms are water-soluble gel compositions that contain apomorphine, optionally together with a permeation enhancer, or transdermal patches.

대표청구항 ▼

[ We claim:] [1.] A dosage form for transdermal delivery of an active form of apomorphine which comprises an adhesive matrix constituted by a medical-grade pressure-sensitive silicone copolymer adhesive, the active form of apomorphine distributed in said matrix in an amount in the range of about 0.1

[ We claim:] [1.] A dosage form for transdermal delivery of an active form of apomorphine which comprises an adhesive matrix constituted by a medical-grade pressure-sensitive silicone copolymer adhesive, the active form of apomorphine distributed in said matrix in an amount in the range of about 0.1 to about 3 percent by weight of the matrix, and a permeation enhancer for said active form of apomorphine present in said matrix in an amount in the range of about 1 to about 10 percent by weight of the matrix, said permeation enhancer being a carbocyclic compound with pendant hydroxyl groups and selected from the group consisting of butylated hydroxyanisole, butylated hydroxytoluene and hydroxypropyl-beta-cyclodextrin, and mixtures thereof wherein said adhesive matrix containing apomorphine is placed in intimate contact with a patient's skin.