A single housing dual compartment hollow fiber membrane dialyzer for hemodialysis is provided having two coaxially oriented hollow fiber membrane bundles encased within the housing. One of the two compartments within the housing is filled with dialysate. The relative orientations of the membranes an
A single housing dual compartment hollow fiber membrane dialyzer for hemodialysis is provided having two coaxially oriented hollow fiber membrane bundles encased within the housing. One of the two compartments within the housing is filled with dialysate. The relative orientations of the membranes and the dialysate simultaneously maximize diffusion, convection and ultrafiltration of fluids, solutes and molecules. During dialyzation, these membranes first separate the blood cells and proteins from the plasma with its toxin solutes and smaller molecules. Then, each blood component is dialyzed separately. Finally, the two components are recombined before being returned to the patient. Since the plasma is not discarded, the need for replacement fluid is substantially reduced or in some cases eliminated.
대표청구항▼
[ What is claimed is:] [1.] An apparatus for removing toxins from a patient's blood having a fluid component and a solid component, said apparatus comprising:a) a substantially translucent shell having an arterial inlet port, a venous outlet port, a dialysate inlet, a dialysate outlet, and an axis,
[ What is claimed is:] [1.] An apparatus for removing toxins from a patient's blood having a fluid component and a solid component, said apparatus comprising:a) a substantially translucent shell having an arterial inlet port, a venous outlet port, a dialysate inlet, a dialysate outlet, and an axis, said shell comprising:an arterial housing having an arterial end, a plasma filtrate exit and a cross-section, wherein said arterial inlet port is adjacent to the arterial end of the arterial housing;a venous housing having a plasma filtrate entrance, a venous end and a cross section such that the plasma filtrate exit of the arterial housing of said shell is axially connected to the plasma filtrate entrance of the venous housing of said shell, wherein the venous outlet port is adjacent to the venous end of venous housing; andb) a first bundle of co-axially oriented hollow fibers, each of said fibers having an arterial end and a venous end, with said bundle having a cross-section corresponding to the cross-section of the arterial housing of said shell, said first bundle adapted to remove a substantial portion of the fluid component from the solid component of the patient's blood to provide a plasma filtrate and a solid portion, respectively, wherein the arterial ends of each fiber are affixed within the arterial housing, adjacent to the arterial inlet port, and wherein the venous ends of each fiber are affixed within the venous housing, adjacent to the venous outlet port; andc) a second bundle of co-axially oriented hollow fibers, each of said fibers having a plasma filtrate end disposed adjacent to said plasma filtrate entrance of the venous housing and a venous end disposed adjacent to said venous outlet port of said venous housing, with said second bundle having a cross-section such that the cross-section of said second bundle plus the cross-section of said first bundle corresponds to the cross-section of the venous housing, said second bundle being in fluid communication with said dialysate inlet and said dialysate outlet and being adapted to receive a dialysate from said dialysate inlet, to remove a substantial portion of the toxins from the plasma filtrate, and to discharge said dialysate through said dialysate outlet, and wherein the plasma filtrate ends of the fibers are affixed adjacent to the plasma filtrate entrance of the venous housing and wherein the venous ends of the fibers are affixed within the venous housing, adjacent to the venous outlet port of said shell;wherein the patient's blood is introduced into said apparatus via the arterial inlet port so that the plasma filtrate is separated in the section of said first bundle positioned within the arterial housing such that when the plasma filtrate is provided to said second bundle and when the solid portion is provided to the section of said first bundle positioned within the venous housing, toxins are more easily removed from the plasma filtrate than the solid portion of the patient's blood.
Pusineri Christian (St Symphorien d\Ozon FRX) Cronenberger Michel (Mornant FRX), Integrated device for the biospecific purification of a liquid containing cellular elements.
Collins, Gregory R.; Summerton, James; Barta, Norman, Dual stage ultrafilter devices in the form of portable filter devices, shower devices, and hydration packs.
Collins, Gregory R.; Summerton, James; Barta, Norman, Dual stage ultrafilter devices in the form of portable filter devices, shower devices, and hydration packs.
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