초록 ▼

Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physic

Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physical or chemical methods. Ancillary structure may be employed to control the rate of release. Standard radionuclides which have been used for local radiotherapy may be used, such as radionuclides of iodine, iridium, radium, cesium, yttrium or other elements.

대표청구항 ▼

[ We claim:] [1.] A method for local radiotherapy at a site in a patient, comprising forming a polymeric depot at a site at which therapy is to be administered by combining one or more radioisotopes with a material capable of polymerizing in vivo to form a biodegradable biocompatible polymeric mater

[ We claim:] [1.] A method for local radiotherapy at a site in a patient, comprising forming a polymeric depot at a site at which therapy is to be administered by combining one or more radioisotopes with a material capable of polymerizing in vivo to form a biodegradable biocompatible polymeric material;administering the combination to a site in a patient to which radiotherapy is to be administered; andpolymerizing the polymerizable material at the site to form a biodegradable, biocompatible polymeric hydrogel,wherein the material includes a functional group selected from the group consisting of epoxy, urethane, ester, amide, sulfone, and ethylenically unsaturated groups.