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Prolonged release of GM-CSF

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/50
  • A61K-009/16
  • A61K-009/48
  • A61F-002/02
출원번호 US-0542445 (1995-10-12)
발명자 / 주소
  • Gombotz Wayne
  • Pettit Dean
  • Pankey Susan
  • Lawter James Ronald
  • Huang W. James
출원인 / 주소
  • American Cyanamid Company
대리인 / 주소
    Arnall Golden & Gregory, LLP
인용정보 피인용 횟수 : 63  인용 특허 : 16

초록

Formulations for controlled, prolonged release of GM-CSF have been developed. These are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof with excipients and drug loadings th

대표청구항

[ We claim:] [1.] A method for delivering GM-CSF to a patient in need thereof comprising administering to the patient an effective amount of GM-CSF dispersed within biodegradable polymeric microparticles providing a sustained, controlled release under physiological conditions over a period of one da

이 특허에 인용된 특허 (16)

  1. Conlon ; III Paul J. (Seattle WA) Grabstein Kenneth H. (Seattle WA), Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor.
  2. Deeley Michael C. (Seattle WA) Gimpel Steven D. (Seattle WA) Price Virginia L. (Seattle WA), Analogs of human granulocyte-macrophage colony stimulating factor.
  3. Deeley Michael C. (Seattle WA) Price Virginia L. (Seattle WA), Analogs of human granulocyte-macrophage colony stimulating factor.
  4. Hutchinson Francis G. (Lymm GBX), Continuous release pharmaceutical compositions.
  5. Eppstein Deborah A. (Palo Alto CA) Schryver Brian B. (Redwood City CA), Controlled release of macromolecular polypeptides.
  6. Deeley Michael C. (Seattle WA) Price Virginia L. (Seattle WA), DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues.
  7. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL), Drug delivery system and method of making the same.
  8. Tice, Thomas R.; Lewis, Danny H.; Cowsar, Donald R.; Beck, Lee R., Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents.
  9. Jaffe Howard (Gaithersburg MD), Microencapsulation process.
  10. Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
  11. Yamamoto Masaki (Osaka JPX) Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Miyagawa Tsutomu (Saitama JPX), Polymer, production and use thereof.
  12. Wantier Henri (Dour BEX) Mathieu Fabienne (Nivelles BEX) Baudrihaye Marc (Waterloo BEX) Delacroix Dominique (Kraainem BEX), Preparation of microparticles for controlled release of water-soluble substances.
  13. Batich Chris (Gainesville FL) Vaghefi Farid (Foster City CA), Process for microencapsulating cells.
  14. Lawter James R. (Goshen NY) Lanzilotti Michael G. (Pearl River NY), Silicone-hardened pharmaceutical microcapsules and process of making the same.
  15. Orsolini Piero (Martigny) Mauvernay Rolland-Yves (Lausanne) Deghenghi Romano (Lausanne CHX), Sustained and controlled release of water insoluble polypeptides.
  16. Igari Yasutaka (Hyogo JPX) Yamada Minoru (Hyogo JPX) Ogawa Yasuaki (Kyoto JPX), Water-soluble composition for sustained-release containing epo and hyaluronic acid.

이 특허를 인용한 특허 (63)

  1. Pham, Chiem V., Acid end group poly(D,L-lactide-co-glycolide) copolymers with high glycolide content.
  2. Pham,Chiem V., Acid end group poly(D,L-lactide-co-glycolide) copolymers with high glycolide content.
  3. Chiem V. Pham, Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content.
  4. Ramstack, J. Michael, Apparatus for preparing microparticles using liquid-liquid extraction.
  5. Sankaram Mantripragada, Biodegradable compositions for the controlled release of encapsulated substances.
  6. Kiser, Patrick F.; Thomas, Allen A., Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments.
  7. Frank W. Falkenberg DE; Oliver C. Krup DE, Compositions and methods for treatment of tumors and metastatic diseases.
  8. Heslet, Lars; Uttenthal, Lars Otto, Compositions comprising granulocyte-macrophage colony-stimulating factor for the treatment of inflammatory bowel disease.
  9. Berg,Richard; Falcone,Samuel; Oppelt,William G.; Cortese,Stephanie M., Compositions of polyacids and polyethers and methods for their use as dermal fillers.
  10. Schwartz, Herbert E.; Blackmore, John M.; Cortese, Stephanie M.; Oppelt, William G., Compositions of polyacids and polyethers and methods for their use in reducing adhesions.
  11. Leung, Karling Alice, Compositions, devices and methods of use thereof for the treatment of cancers.
  12. Garver, Robert I.; Kalyanasundaram, Subramanian; Leong, Kam W., Controlled release of bioactive substances.
  13. Shoichet, Molly S.; Baumann, M. Douglas; Kang, Catherine Elizabeth, Enhanced stability of inverse thermal gelling composite hydrogels.
  14. Smith, Jay S.; Cole, Michael R.; Whitson, Amy K., Implant placement guide.
  15. Smith, Jay S.; Cole, Michael R.; Whitson, Amy K., Implant placement guide.
  16. Narayan, Opendra; Buch, Shilpa, Inhibition of HIV and SHIV replication with antisense interleukin-4.
  17. Hinds, Kenneth; Lewis, Danny; Schmidt, Paul; Campbell, Kathleen M., Materials and methods for preparing protein-polymer conjugates.
  18. Bernstein, Howard; Chickering, Donald; Khattak, Sarwat; Straub, Julie, Matrices formed of polymer and hydrophobic compounds for use in drug delivery.
  19. Bernstein, Howard; Chickering, Donald; Khattak, Sarwat; Straub, Julie, Matrices formed of polymer and hydrophobic compounds for use in drug delivery.
  20. Bernstein,Howard; Chickering,Donald; Khattak,Sarwat; Straub,Julie, Matrices formed of polymer and hydrophobic compounds for use in drug delivery.
  21. Bernstein,Howard; Chickering,Donald; Khattak,Sarwat; Straub,Julie, Matrices formed of polymer and hydrophobic compounds for use in drug delivery.
  22. Howard Bernstein ; Donald Chickering ; Sarwat Khattak ; Julie Straub, Matrices formed of polymer and hydrophobic compounds for use in drug delivery.
  23. Gold, Daniel P.; Shopes, Robert J., Method and composition for altering a B cell mediated pathology.
  24. Gold, Daniel P.; Shopes, Robert J., Method and composition for altering a B cell mediated pathology.
  25. Gold, Daniel P.; Shopes, Robert J., Method and composition for altering a B cell mediated pathology.
  26. Gold, Daniel P.; Shopes, Robert J., Method and composition for altering a B cell mediated pathology.
  27. Steven G. Wright ; Michael E. Rickey ; J. Michael Ramstack ; Shawn L. Lyons ; Joyce M. Hotz, Method for preparing microparticles having a selected polymer molecular weight.
  28. Wright, Steven G.; Rickey, Michael E.; Ramstack, J. Michael; Lyons, Shawn L.; Hotz, Joyce M., Method for preparing microparticles having a selected polymer molecular weight.
  29. Ramstack, J. Michael, Method for preparing microparticles using liquid-liquid extraction.
  30. Seo Young Jeong KR; Kuiwon Choi KR; Ick-Chan Kwon KR; Yong-Hee Kim KR; Jae Bong Choi KR; Kyu Back Lee KR, Method of manufacturing porous matrix-type controlled release systems using emulsion technique.
  31. Lewis, Danny; Schmidt, Paul; Hinds, Kenneth, Methods and compositions for enhanced delivery of bioactive molecules.
  32. Yeo, Yoon; Chen, Alvin Un-Teh; Basaran, Osman A.; Park, Kinam, Microencapsulation of drugs by solvent exchange.
  33. Gustavsson,Nils Ove; J철nsson,Monica; Laakso,Timo; Reslow,Mats; Bj철rn,S철ren; Drustrup,J철rn, Microparticle preparation.
  34. Park Jong Sang,KRX ; Choi Young Hun,KRX ; Kim Sung Wan, Polyester analogue of poly-L-lysine as a soluble, biodegradable gene delivery carrier.
  35. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
  36. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
  37. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Fineman, Mark; Smith, Christine; Ong, John; Lokensgard, David M.; Costantino, Henry R., Polymer-based sustained release device.
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  40. Straub,Julie A.; Bernstein,Howard; Chickering, III,Donald E.; Khattak,Sarwat; Randall,Greg, Porous paclitaxel matrices and methods of manufacture thereof.
  41. Nomura,Hideaki; Ueki,Yosuke, Powdery preparation for transmucosal administration containing a polymeric form of drug and exhibiting improved storage stability.
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  47. Hartounian, Hartoun; Meissner, Dagmar; Pepper, Clint B., Production of multivesicular liposomes.
  48. Gombotz Wayne R. ; Pettit Dean K. ; Pankey Susan C., Prolonged release of GM-CSF.
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  57. Hinds, Kenneth; Lewis, Danny; Schmidt, Paul; Campbell, Kathleen M., Site-specific insulin-polymer conjugates.
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  61. Kim, Sinil; Kim, Taehee; Murdande, Sharad, Sustained-release liposomal anesthetic compositions.
  62. Alessi, Thomas R.; Baron, Michelle, Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c.
  63. Setterstrom Jean A. ; Van Hamont John E. ; Reid Robert H. ; Jacob Elliot ; Jeyanthi Ramasubbu ; Boedeker Edgar C. ; McQueen Charles E. ; Jarboe Daniel L. ; Cassels Frederick ; Brown William ; Thies C, Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix.
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