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Method for molecular diagnosis of tumor angiogenesis and metastasis 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/00
  • G01N-033/53
  • C12N-005/08
  • C07H-021/04
출원번호 US-0624858 (1996-03-21)
발명자 / 주소
  • Hirth Klaus Peter
출원인 / 주소
  • Sugen, Inc.
대리인 / 주소
    Pennie & Edmonds LLP
인용정보 피인용 횟수 : 74  인용 특허 : 3

초록 ▼

The invention is directed to methods of assessing the molecular stage of an disease characterized by abnormal angiogenesis. More particularly, the invention is directed to a method of determining the metastatic potential of a tumor by determining the presence of specific molecular markers. The inven

대표청구항 ▼

[ What is claimed is:] [1.] A method of detecting metastasis at a site distal from a primary tumor in a human comprising:a) assaying a sample of cells from the human for the presence of VEGF transcripts; andb) determining the existence of metastasis wherein the abnormal presence of VEGF transcripts

이 특허에 인용된 특허 (3)

  1. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
    상세보기
  2. Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
    상세보기
  3. Ladner Robert C. (Ijamsville MD) Bird Robert E. (Rockville MD) Hardman Karl (Chevy Chase MD), Single polypeptide chain binding molecules.
    상세보기

이 특허를 인용한 특허 (74)

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  3. Kavlie, Anita; Schlunegger, Kyle, Anti-VEGF antibody compositions and methods.
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  4. Shitara, Kenya; Ito, Mikito; Hanai, Nobuo, Anti-human VEGF receptor Flt-1 monoclonal antibody.
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  5. Plouet, Jean; Jonca, Frederic; Ortega, Nathalie; Ruchoux, Marie-Magdeleine, Anti-idiotypic antibodies of vascular endothelial growth factor and use thereof as drugs.
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  6. Thorpe, Philip E.; Brekken, Rolf A., Antibody conjugate formulations for selectively inhibiting VEGF.
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  7. Thorpe, Philip E.; Brekken, Rolf A., Antibody conjugate methods for selectively inhibiting VEGF.
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  8. Thorpe, Philip E.; Brekken, Rolf A., Antibody kits for selectively inhibiting VEGF.
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  9. Thorpe, Philip E.; Brekken, Rolf A., Antibody methods for selectively inhibiting VEGF.
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  10. Thorpe,Philip E.; Brekken,Rolf A., Antibody methods for selectively inhibiting VEGF.
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  11. Kornblith, Paul L., Assaying cellular markers for the evaluation of tumors.
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  18. Graham, Charles H.; Postovit, Lynn-Marie; Adams, Michael A.; Heaton, Jeremy P. W., Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype.
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  24. Cai, Shaopei; Chou, Joyce; Harwood, Eric; Heise, Carla C.; Machajewski, Timothy D.; Ryckman, David; Shang, Xiao; Wiesmann, Marion; Zhu, Shuguang, Inhibition of FGFR3 and treatment of multiple myeloma.
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  25. Saris, Chris, Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family.
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  27. Arbogast, Christophe; Bussat, Philippe; Fan, Hong (Helen); Khurana, Sudha; Linder, Karen E.; Marinelli, Edmund R.; Nanjappan, Palaniappa; Nunn, Adrian D.; Pillai, Radhakrishna K.; Pochon, Sibylle; Ramalingam, Kondareddiar; Shrivastava, Ajay; Song, Bo; Swenson, Rolf E.; Von Wronski, Mathew A.; Yan, Feng, KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy.
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  28. Arbogast, Christophe; Bussat, Philippe; Fan, Hong; Khurana, Sudha; Linder, Karen E.; Marinelli, Edmund R.; Nanjappan, Palaniappa; Nunn, Adrian D.; Pillai, Radhakrishna K.; Pochon, Sibylle; Ramalingam, Kondareddiar; Shrivastava, Ajay; Song, Bo; Swenson, Rolf E.; Von Wronski, Mathew A.; Yan, Feng, KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy.
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  30. Sato, Aaron K.; Sexton, Daniel J.; Dransfield, Daniel T.; Ladner, Robert Charles, KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy.
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