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Method of promoting bone growth with hyaluronic acid and growth factors 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/715
출원번호 US-0811971 (1997-03-05)
발명자 / 주소
  • Radomsky Michael
출원인 / 주소
  • Orquest, Inc.
대리인 / 주소
    Fish & Richardson P.C.
인용정보 피인용 횟수 : 29  인용 특허 : 38

초록 ▼

A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at the site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used

대표청구항 ▼

[ What is claimed is:] [1.] A composition for treatment of diseased, injured or abnormal bone comprising an effective amount of a mixture of a growth factor and hyaluronic acid sufficient to enhance bone growth rate and magnitude and having a sufficient viscosity and biodegradability to persist upon

이 특허에 인용된 특허 (38)

  1. Seddon Andrew P. (Monroe NY) Bohlen Peter (Peekskill NY), Active fragments of fibroblast growth factor.
    상세보기
  2. Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable system for regenerating the periodontium.
    상세보기
  3. Ng Steve Y. W. (San Francisco CA) Heller Jorge (Woodside CA), Bioerodible polymers useful for the controlled release of therapeutic agents.
    상세보기
  4. Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239), Bone graft material for osseous defects and method of making same.
    상세보기
  5. Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239) Gutmann James L. (10112 Daventry Dr. Cockeysville MD 21030) Heatfield Barry M. (33 Penny La. Baltimore MD 21209), Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same.
    상세보기
  6. Schlameus Herman W. (San Antonio TX) Fox William C. (San Antonio TX) Mangold Donald J. (San Antonio TX) Triplett Robert G. (Dallas TX) Holt George R. (San Antonio TX) Aufdemorte Thomas B. (Lakeway TX, Composition and method of promoting hard tissue healing.
    상세보기
  7. Sander Thomas W. (Newtown CT) Kaplan Donald S. (Weston CT), Composition for effecting bone repair.
    상세보기
  8. Snyders ; Jr. Robert V. (645 S. New Ballas Rd.-Apt. No. 1D St. Louis MO 63141), Composition of material for osseous repair.
    상세보기
  9. Fukunaga Kazuhiro (Tokyo JPX) Hijikata Shigeki (Tokyo JPX) Ishimura Kimihiro (Tokyo JPX) Ohtani Yoshiro (Tokyo JPX) Kimura Kunio (Tokyo JPX) Fujii Masahiro (Tokyo JPX) Hata Yoshiyuki (Tokyo JPX), Composition of stabilized fibroblast growth factor.
    상세보기
  10. Edelman Elazer R. (Brookline MA) Langer Robert S. (Somerville MA) Klagsburn Michael (Newton MA) Mathiowitz Edith (Brookline MA), Controlled release systems containing heparin and growth factors.
    상세보기
  11. Hanson Stephen R. (Stone Mountain GA), Device for local drug delivery and methods for using the same.
    상세보기
  12. Balazs Endre A. (Ft. Lee NJ) Leshchiner Adolf (Fairview NJ) Larsen Nancy E. (Ridgefield Park NJ), Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same.
    상세보기
  13. Foster Linda (Sunnyvale CA) Thompson Stewart A. (Mountain View CA) Tarnowski S. Joseph (Sunnyvale CA), Formulations for stabilizing fibroblast growth factor.
    상세보기
  14. Finkenaur Amy L. (Somerville NJ) Cohen Jonathan M. (Marlboro NJ) Shalaby Shalaby W. (Lebanon NJ) Sandoval Elisabeth A. (Irvine CA) Bezwada Rao S. (Whitehouse Station NJ) Kronenthal Richard L. (Fairla, Gel formulations containing growth factors and acrylamide polymer.
    상세보기
  15. Hunziker Ernst B. (Riedholz CHX), Method and compositions for the treatment and repair of defects or lesions in cartilage.
    상세보기
  16. Bechgaard Erik (Hellerup DKX) Gizurarson Sveinbjrn (Keflavik ISX) Hjortkjaer Rolf K. (Humlebaer DKX), Method of administering a biologically active substance.
    상세보기
  17. Ammann Arthur J. (San Rafael CA) Rudman Christopher G (San Francisco CA), Method of inducing bone growth using TGF-b 상세보기
  • Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239), Method of inducing osseous formation by implanting bone graft material.
    상세보기
  • Farber Bruce (Port Washington NY), Method of reducing medical device related infections.
    상세보기
  • Cid Maria C. (Bethesda MD) Grant Derrick S. (Beltsville MD) Kleinman Hynda K. (Bethesda MD) Hoffman Gary S. (Gaithersburg MD), Method of stimulating angiogenesis.
    상세보기
  • Levy Julia G. (Vancouver CAX) Dolphin David (Vancouver CAX) Chow Jack J. (Vancouver CAX) Sternberg Ethan (Vancouver CAX), Method of treating skin diseases.
    상세보기
  • Thompson Stewart A. (Mountain View CA), Method to stabilize basic fibroblast growth factor.
    상세보기
  • Hunziker Ernst B. (Riedholz CHX), Methods and compositions for the treatment and repair of defects or lesions in cartilage.
    상세보기
  • Oppermann Hermann (Medway MA) Ozkaynak Engin (Milford MA) Kuberasampath Thangavel (Medway MA) Rueger David C. (Hopkinton MA) Pang Roy H. L. (Medway MA), Osteogenic devices.
    상세보기
  • Oppermann Hermann (Medway MA) Ozkaynak Engin (Milford MA) Kuberasampath Thangavel (Medway MA) Rueger David C. (Hopkinton MA) Pang Roy H. L. (Medway MA), Osteogenic proteins.
    상세보기
  • Prisell Per (Wollmar Yxkullsgatan 15A S-116 50 Stockholm SEX) Norstedt Gunnar (Foerfattavaegen 46 S-116 42 Bromma SEX), Pharmaceutical preparation.
    상세보기
  • Amsden Brian G. (40 Fountainhead Rd. ; Apt. #1516 Downsview ; Ontario M3J 2V1 CAX) Cheng Yu-Ling (1399 Glenburnie Rd. Mississauga Ontario L5G 3C7 CAX), Polymer-based drug delivery system.
    상세보기
  • Johansson Thomas (Hgans SEX), Porous implant with two sets of pores.
    상세보기
  • Chesterfield Michael P. (Norwalk CT) Muth Ross R. (Brookfield CT) Kennedy John (Stratford CT), Process for preparing particles of bioabsorbable polymer.
    상세보기
  • della Valle Francesco (Padova ITX) Romeo Aurelio (Rome ITX) Lorenzi Silvana (Padova ITX), Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing th.
    상세보기
  • Folkman Moses J. (Brookline MA) Shing Yuen (Randolph MA), Stabilized FGF composition.
    상세보기
  • Middaugh C. Russell (Quakertown PA) Tsai Pei-Kuo (Blue Bell PA) Volkin David B. (Doylestown PA), Stabilizers for fibroblast growth factors.
    상세보기
  • Ammann Arthur J. (San Rafael CA) Rudman Christopher G. (San Francisco CA), TGF-b 상세보기
  • Ammann Arthur J. (460 Point San Bruno Blvd. South San Francisco CA 94080-4990) Beck Steven L. (460 Point San Bruno Blvd. South San Francisco CA 94080-4990) Nguyen Tue H. (460 Point San Bruno Blvd. So, TGF-b 상세보기
  • Lindstrom Richard L. (1741 Archer Ct. Plymouth MN 55447) Skelnik Debra (P.O. Box 758 ; Rte. 1 Cambridge MN 55008), Viscoelastic solution.
    상세보기
  • Lindstrom Richard L. (20050 Lakeview Ave. Excelsior MN 55331) Skelnik Debra (P.O. Box 758 ; Rte. 1 Cambridge MN 55008), Viscoelastic solution.
    상세보기
  • Igari Yasutaka (Kobe JPX) Yamada Minoru (Kawanishi JPX) Ishiguro Seiko (Kawanishi JPX), Water-soluble composition for sustained-release.
    상세보기
  • Igari Yasutaka (Hyogo JPX) Yamada Minoru (Hyogo JPX) Ogawa Yasuaki (Kyoto JPX), Water-soluble composition for sustained-release containing epo and hyaluronic acid.
    상세보기

    • 이 특허를 인용한 특허 (29)

    1. Attawia, Mohamed; Serhan, Hassan; DiMauro, Thomas M.; Grace, Melissa; Urbahns, David, Autologous treatment of degenerated disc with cells.
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    2. Lally, Thomas Joseph, Bio-material composition and method for spinal fusion.
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    3. Atkinson, Brent L.; Hanks, Tracey S., Bone repair putty.
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    4. Atkinson, Brent L.; Hanks, Tracey S., Bone repair putty.
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    5. J. Alexander Marchosky, Compositions and methods for forming and strengthening bone.
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    6. Marchosky, J. Alexander, Compositions and methods for forming and strengthening bone.
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    7. Marchosky, Jose Alexander, Compositions and methods for forming and strengthening bone.
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    8. Pike,Marilyn C.; Wolfgang,Grushenka H. I; Chen,Sharon A.; Owen,Ralph M.; Seely,Lynn B.; Guler,Hans Peter, Compositions and methods for treating articular cartilage disorders.
      상세보기
    9. McGraw, Michael B.; Rux, William A.; Carroll, William J.; Terrell, Richard M.; Murphy, Randy Alan, Electrical stimulation combined with a biologic to increase osteogenesis.
      상세보기
    10. McGraw, Michael B.; Rux, William A.; Carroll, William J.; Terrell, Richard M.; Murphy, Randy Alan, Electro-medical device for use with biologics.
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    11. McGraw, Michael B.; Rux, William A.; Carroll, William J.; Terrell, Richard M.; Murphy, Randy Alan, Electro-medical device for use with biologics.
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    12. Kim, Hyun; Li, Rebecca; Pavesio, Alessandra; Callegaro, Lanfranco; Seeherman, Howard; Wozney, John, Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins.
      상세보기
    13. Kim,Hyun; Li,Rebecca; Pavesio,Alessandra; Callegaro,Lanfranco; Seeherman,Howard; Wozney,John, Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins.
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    14. Spiro Robert C. ; Liu LinShu, Injectable hyaluronate-sulfated polysaccharide conjugates.
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    15. Li, Rebecca H.; Kim, Hyun D., Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins.
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    16. Sommerich, Robert E.; Presbrey, Glen Arthur; Meer, Martin; Pohl, Gerhard; Ray, Katherine Herard, Instruments for expandable corpectomy spinal fusion cage.
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    17. DiMauro, Thomas M.; Attawia, Mohamed; Serhan, Hassan; Grace, Melissa; Slivka, Michael; Ferro, Thomas G.; Shenoy, Vivek N.; Cook, Alonzo D.; Bruder, Scott, Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor.
      상세보기
    18. McGraw,Michael B.; Rux,William A.; Carroll,William J.; Terrell,Richard M.; Murphy,Randy Alan, Multi-functional portable electro-medical device.
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    19. Michael B. McGraw ; William A. Rux ; William J. Carroll ; Richard M. Terrell ; Randy Alan Murphy, Multi-functional portable electro-medical device.
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    20. Attawia, Mohamed; O'Neil, Michael J, Tissue augmentation, stabilization and regeneration technique.
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    21. DiMauro, Thomas M.; Attawia, Mohamed; Serhan, Hassan; Reynolds, Martin A.; Grace, Melissa; Kadiyala, Sudhakar; Urbahns, David; Bruder, Scott; Collins, Gregory; Brown, Laura J.; Geesin, Jeff; Plouhar, Pamela L.; Smith, Catherine; Siekierka, John, Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints.
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    22. Brown, Laura J.; Geesin, Jeffery C.; Fang, Carrie H.; Siekierka, John J., Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints.
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    23. Serhan, Hassan; Attawia, Mohamed; DiMauro, Thomas M.; Kadiyala, Sudhakar; Urbahns, David; Bruder, Scott, Transdiscal administration of anti-TNFα antibodies and growth differentiation factors.
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    24. Attawia, Mohamed; DiMauro, Thomas M.; Serhan, Hassan; Kadiyala, Sudhakar; Urbahns, David; Bruder, Scott; Brown, Laura J.; Geesin, Jeffrey C., Transdiscal administration of cycline compounds.
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    25. Attawia, Mohamed; DiMauro, Thomas M.; Serhan, Hassan; Kadiyala, Sudhakar; Urbahns, David; Collins, Gregory; Brown, Laura J.; Geesin, Jeffrey C., Transdiscal administration of cycline compounds.
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    26. Serhan,Hassan; DiMauro,Thomas M.; Attawia,Mohamed; Kadiyala,Sudhakar; Urbahns,David; Bruder,Scott; Brown,Laura J.; Geesin,Jeffrey C., Transdiscal administration of high affinity anti-MMP inhibitors.
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    27. Attawia, Mohamed; DiMauro, Thomas M.; Serhan, Hassan; Kadiyala, Sudhakar; Urbahns, David; Bruder, Scott, Transdiscal administration of specific inhibitors of pro-inflammatory cytokines.
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    28. DiMauro,Thomas M.; Serhan,Hassan; Attawia,Mohamed, Transdiscal administration of specific inhibitors of pro-inflammatory cytokines.
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    29. Attawia, Mohamed; Serhan, Hassan; DiMauro, Thomas M.; Grace, Melissa; Urbahns, David, Treatment of degenerated disc with autologous cells.
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