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Method for making non-crosslinked protein particles for therapeutic and diagnostic use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • B01J-013/00
  • A61K-009/50
  • B32B-005/16
출원번호 US-0747137 (1996-11-12)
발명자 / 주소
  • Yen Richard C. K.
출원인 / 주소
  • Hemosphere, Inc.
대리인 / 주소
    Townsend and Townsend and Crew LLP
인용정보 피인용 횟수 : 32  인용 특허 : 17

초록 ▼

Albumin particles in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolubilization without the aid of a crosslinking agent and without denaturation, by the incorporation of hemoglobin in the particle composition. Particles which are primarily hemoglobi

대표청구항 ▼

[ What is claimed is:] [1.] A method for the preparation of an aqueous suspension of monodisperse particles of non-crosslinked, non-denatured albumin, having a size range of from about 50 to about 5000 nanometers in diameter and stable against dissolving upon dilution with an alcohol-free aqueous di

이 특허에 인용된 특허 (17)

  1. Yapel ; Jr. Anthony F. (Saint Paul MN), Albumin medicament carrier system.
    상세보기
  2. Ecanow Bernard (Wilmette IL), Drug delivery compositions and methods.
    상세보기
  3. Gibson Suzanne M. (Piscataway NJ) Strauss George (Piscataway NJ) Wasserman Bruce P. (Belle Mead NJ), Heat stable fat substitute compositions and process.
    상세보기
  4. Ithakissios ; Dionyssis S., In vitro diagnostic test.
    상세보기
  5. Oppenheim ; Richard Charles ; Marty ; Jennifer Joy ; Speiser ; Peter, Injectable compositions, nanoparticles useful therein, and process of manufacturing same.
    상세보기
  6. Arai Motoharu (Tokyo JPX) Ito Masatsugu (Tokyo JPX), Lipid powder having cross-linked coating thereon and process for preparing same.
    상세보기
  7. Yen Richard C. K. (4261 Chase Ave. Los Angeles CA 90066), Manufacturing protein microspheres.
    상세보기
  8. Hunziker Ernst B. (Riedholz CHX), Method and compositions for the treatment and repair of defects or lesions in cartilage.
    상세보기
  9. Ekman Bo (MalmSEX) Lindahl ke (Skurup SEX), Method for producing small, spherical polymer particles.
    상세보기
  10. Senyei Andrew E. (Chicago IL) Widder Kenneth J. (Chicago IL), Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres.
    상세보기
  11. Spence Kemet D. (Potlatch ID) Andrews Robert E. (Pullman WA), Microbial insecticide.
    상세보기
  12. Chen Wehn-Sherng (Glenview IL) Henry George A. (Wilmette IL) Gaud Susan M. (Evanston IL) Miller Mark S. (Arlington Heights IL) Kaiser John M. (Glenview IL) Balmaceda Estela A. (Winnetka IL) Morgan Ro, Microfragmented ionic polysaccharide/protein complex dispersions.
    상세보기
  13. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
    상세보기
  14. Chia Han-Lie (Reinach CHX) Woltmann Siegfried (Magden CHX), Process for the preparation of physiologically degradable, colloidal radioisotope carriers and their use.
    상세보기
  15. Devissaguet Jean-Philippe (Neuilly sur Seine FRX) Fessi Hatem (Paris FRX) Puisieux Francis (Maisons Alfort FRX), Process for the preparaton of dispersible colloidal systems of a substance in the form of nanocapsules.
    상세보기
  16. Yen Richard C. K. (Glendora CA), Protein nanomatrixes and method of production.
    상세보기
  17. Kunihiro Yasuyuki (Shinjuku JPX) Tanaka Ryo (Shinjuku JPX) Hata Seishichi (Shinjuku JPX) Yamada Koji (Shinjuku JPX), Thrombin composition for oral administration.
    상세보기

이 특허를 인용한 특허 (32)

  1. Krantz,Alexander; Huang,Wolin; Hanel,Arthur M.; Holmes,Darren L.; Bridon,Dominique P., Affinity markers for human serum albumin.
    상세보기
  2. Ezrin, Alan M.; Bridon, Dominique P.; Holmes, Darren L.; Milner, Peter G., Antinociceptive agent derivative.
    상세보기
  3. Quay,Steven C.; Brandt,Gordon, Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity.
    상세보기
  4. Quay,Steven C.; Brandt,Gordon; Kleppe,Mary S.; MacEvilly,Conor J., Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity.
    상세보기
  5. Quay,Steven C.; Brandt,Gordon; Kleppe,Mary S.; MacEvilly,Conor J., Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity.
    상세보기
  6. Quay,Steven C.; Brandt,Gordon; Kleppe,Mary S.; MacEvilly,Conor J., Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity.
    상세보기
  7. Quay,Steven C, Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity.
    상세보기
  8. Schacter, Bernice; Schacter, Lee P., Compositions and methods for promoting lipid mobilization in humans.
    상세보기
  9. Schacter,Bernice; Schacter,Lee P., Compositions and methods for promoting lipid mobilization in humans.
    상세보기
  10. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
    상세보기
  11. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
    상세보기
  12. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
    상세보기
  13. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
    상세보기
  14. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
    상세보기
  15. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
    상세보기
  16. Alan M. Ezrin ; Dominique P. Bridon CA; Darren L. Holmes CA; Peter G. Milner, Conjugate comprising an antinociceptive agent covalently bonded to a blood component.
    상세보기
  17. Alan M. Ezrin ; Dominique P. Bridon CA; Darren L. Holmes CA; Peter G. Milner, Conjugates of opioids and endogenous carriers.
    상세보기
  18. Desai, Neil P.; Soon-Shiong, Patrick, Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof.
    상세보기
  19. Desai, Neil P.; Tao, Chunlin; Yang, Andrew; Louie, Leslie; Soon-Shiong, Patrick, Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof.
    상세보기
  20. Ezrin, Alan M.; Bridon, Dominique P.; Holmes, Darren L.; Milner, Peter G., Method for alleviating pain or providing an analgesic effect in a patient.
    상세보기
  21. Lin, Henry C., Methods for manipulating satiety.
    상세보기
  22. Lin, Henry C., Methods for manipulating satiety.
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  23. Lin,Henry C., Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia.
    상세보기
  24. Lin,Henry C., Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia.
    상세보기
  25. Lin, Henry C., Methods for treating irritable bowel syndrome.
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  26. Lin, Henry C.; Pimentel, Mark, Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions.
    상세보기
  27. Lin, Henry C.; Pimentel, Mark, Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions.
    상세보기
  28. Lin, Henry C.; Pimentel, Mark, Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions.
    상세보기
  29. Lin, Henry C.; Pimentel, Mark, Methods of treating autoimmune diseases caused by small intestinal bacterial overgrowth.
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  30. Collin, Peter Donald, Peptides having anti-cancer and anti-inflammatory activity.
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  31. Ezrin, Alan M.; Fleser, Angelica; Robitaille, Martin; Milner, Peter G.; Bridon, Dominique P., Pulmonary delivery for bioconjugation.
    상세보기
  32. Brown,Anne B.; Brown,David A.; Yarosh,Daniel B., Stabilization of T4 endonuclease V.
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