초록 ▼

A controlled release tablet including a pharmaceutical agent and an excipient. The excipient includes at least about 60% of a water swellable polymer and a lubricant. The water swellable polymer is chosen such that the swelling rate of the polymer is equal to the dissolution rate of the swollen poly

A controlled release tablet including a pharmaceutical agent and an excipient. The excipient includes at least about 60% of a water swellable polymer and a lubricant. The water swellable polymer is chosen such that the swelling rate of the polymer is equal to the dissolution rate of the swollen polymer. The excipient may also include such other ingredients as diluents, fillers, binders, solubilizers, emulsifiers, and other pharmacologically inactive compounds. The polymer is chosen with the pharmaceutical agent in mind such that the tablet will be fully dissolved at the same time that the last of the pharmaceutical agent is released.

대표청구항 ▼

[ What is claimed:] [1.] A controlled release tablet consisting essentially of a single homogeneous mixture of a pharmaceutical agent selected from the group consisting of nifedipine, diclofenac sodium, salicylic acid, theophylline anhydrous, sulfapyridine, sulfadrazine, propranolol hydrochloride, d

[ What is claimed:] [1.] A controlled release tablet consisting essentially of a single homogeneous mixture of a pharmaceutical agent selected from the group consisting of nifedipine, diclofenac sodium, salicylic acid, theophylline anhydrous, sulfapyridine, sulfadrazine, propranolol hydrochloride, diltiazem hydrochloride, glipizide, and sulfathiazole, a solubilizing agent, and an excipient, wherein said excipient comprises:polyethylene oxide and a lubricant; andwherein the pharmaceutical agent is released from the tablet at a rate expressed as M.sub.t /M.sub.T =kt.sup.n where:t is time,M.sub.t is the amount of the pharmaceutical agent which has been released at time t,M.sub.T is the total amount of the pharmaceutical agent contained in the tablet,k is a constant, andn is the release kinetics exponent; andwherein the molecular weight and the solubility, respectively, of said polyethylene oxide and the pharmaceutical agent are selected such that n is about 0.89 to 1.0.