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Chemical and physical enhancers and ultrasound for transdermal drug delivery 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61B-017/00
출원번호 US-0574377 (1995-12-18)
발명자 / 주소
  • Johnson Mark E.
  • Mitragotri Samir S.
  • Blankschtein Daniel
  • Langer Robert S.
  • Pishko Michael
  • Kost Joseph,ILX
출원인 / 주소
  • Massachusetts Institute of Technology
대리인 / 주소
    Arnall Golden & Gregory, LLP
인용정보 피인용 횟수 : 235  인용 특허 : 45

초록

Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by providing chemical enhancers which increase the solubility of the compound to be transported and/or lipid bilayer solubility, and/or additional driving forces for transport, such as mechanical

대표청구항

[ We claim:] [1.] A method for enhancing transdermal transport of compounds comprising administering to the skin an effective amount of ultrasound in combination with linoleic acid in an ethanol solution.

이 특허에 인용된 특허 (45)

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  2. Stanley Theodore H. (Salt Lake City UT) Ebert Charles D. (Salt Lake City UT) Higuchi William I. (Salt Lake City UT) Zhang Jie (Salt Lake City UT), Apparatus and method for noninvasive blood glucose monitoring.
  3. Heller Jorge (Palo Alto CA) Baker Richard W. (Bend OR), Bioerodible system for delivering drug manufactured from poly(carboxylic acid).
  4. Tachibana Shunro (Fukuoka JPX) Sogawa Ichiro (Osaka JPX) Tachibana Katsuro (Fukuoka JPX), Blood processing for treating blood disease.
  5. Tachibana Katsuro (6-18 ; Kusagae 1-chome ; Chuo-ku Fukuoka-shi ; Fukuoka 810 JPX) Tachibana Shunro (6-18 ; Kusagae 1-chome ; Chuo-ku Fukuoka-shi ; Fukuoka 810 JPX), Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same.
  6. Weaver James C. (Sudbury MA) Powell Kevin T. (Boston MA) Langer ; Jr. Robert S. (Newton MA), Control of transport of molecules across tissue using electroporation.
  7. Takemoto ; Kiyochika ; Suzuki ; Yasuo ; Ochiai ; Yoshihito ; Nakashima ; Syozi ; Hayashi ; Midori, Devices for transmitting ultrasonic waves to teeth.
  8. Tachibana Katsuro (6-18 ; Kusagae 1-chome Chuo-ku ; Fukuoka-shi ; Fukuoka 810 JPX) Tachibana Shunro (6-18 ; Kusagae 1-chome Chuo-ku ; Fukuoka-shi ; Fukuoka 810 JPX), Drug administration and humor sampling unit and an apparatus therefor.
  9. Shimada Jin (Falcon Heights MN) Shapland James E. (Shoreview ; both MN), Drug delivery by multiple frequency phonophoresis.
  10. D\Angelo Joseph P. (Miami FL) Schur Henry (Miami FL), Electronic transdermal drug delivery system.
  11. Tachibana Shunro (1-6-18 ; Kusagae Chuo-ku ; Fukuoka-shi ; Fukuoka-ken JPX) Shibata Uichi (Tokyo JPX), Endermic application kits for external medicines.
  12. Tachibana Shunro (1-6-18 Kusagae ; Chuo-ku ; Fukuoka-shi ; Fukuoka-ken JPX) Shibata Uichi (Tokyo JPX), Endermic application kits for external medicines.
  13. Tachibana Shunro (Fukuoka JPX) Shibata Uichi (Tokyo JPX), Endermic application kits for external medicines.
  14. Flanagan Dennis F. (1671 W. Main St. Willimantic CT 06226), Endermic method and apparatus.
  15. Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT), Enhancement of transdermal delivery with ultrasound and chemical enhancers.
  16. Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT) Kost Joseph (Omer MA ILX) Langer Robert S. (Newton MA), Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers.
  17. Kobayashi Atsushi (Nagano JPX) Suzuki Takashi (Nagano JPX) Kosugi Yasuhiko (Nagano JPX), Image forming apparatus.
  18. Kalish Stanley (2727 De Anza Rd. ; M-22 San Diego CA 92109), Impregnated bandage.
  19. Tachibana Shunro (6-18 ; Kusagae 1-chome Chuo-ku ; Fukuoka-shi ; Fukuoka-ken JPX), Injection instrument with ultrasonic oscillating element.
  20. Henley Julian L. (38 Munger Rd. Guilford CT 06437), Ionosonic drug delivery apparatus.
  21. Driller Jack (Ridgewood NJ) Faulkenberry William J. (Long Island City NY) Lizzi Frederic L. (Tenafly NJ), Local application of medication with ultrasound.
  22. Rosler, Richard S.; Engle, George M., Metal-silicide deposition using plasma-enhanced chemical vapor deposition.
  23. Schoendorfer Donald W. (Santa Ana CA) Miller William R. (Santa Ana CA), Method and apparatus for determination of chemical species in body fluid.
  24. Sterzer Fred (Lawrence Township ; Mercer County NJ), Method for enhancing delivery of chemotherapy employing high-frequency force fields.
  25. Moasser Manoutchehr (16005 Crain Hwy. Brandywine MD 20613), Method for treating herpes lesions and other infectious skin conditions.
  26. Nuwayser Elie S. (Wellesley MA), Method of transdermal drug delivery.
  27. Buchalter Gilbert (555 Mount Prospect Ave. Newark NJ 07104), Method of transmitting ultrasonic impulses to surface using transducer coupling agent.
  28. Schroeder Jon M. (14301 Bagdad Rd. Leander TX 78641) Long Joseph F. (1335 Lost Creek Rd. Austin TX 78746), Noninvasive blood glucose measuring device.
  29. Cooper, Eugene R., Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone.
  30. Patel Dinesh C. (Murray UT) Chang Yunik (Lakewood NJ), Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols.
  31. Henley Julian L. (330 Orchard St. New Haven CT 06511-4417), Programmable apparatus for the transdermal delivery of drugs and method.
  32. Cleary Gary W. (San Mateo CA) Roy Samir (Redwood City CA), Resilient transdermal drug delivery device.
  33. Korol Bernard (11908 Country Club Dr. St. Louis MO 63131), Synthetic resin wound dressing and method of treatment using same.
  34. Cosgrove ; Jr. Robert J. (5009 Juiata Dr. Birmingham AL 35210) Smolen Victor F. (227 Timbercrest Rd. West Lafayette IN 47905), System for automatic feedback-controlled administration of drugs.
  35. Fahim Mostafa S. (Columbia MO), Topical application of medication by ultrasound with coupling agent.
  36. Takemoto Kiyochika (Kodaira JPX) Suzuki Yasuo (Kurume JPX) Ochiai Yoshihito (Fujisawa JPX) Nakashima Syozi (Yamanishi JPX) Hayashi Midori (Yamakita JPX), Torsional ultrasonic vibrators.
  37. Sanders Harold F. (Palo Alto CA) Cheng Yu-Ling (Cupertino CA) Enscore David J. (Saratoga CA) Libicki Shari B. (Palo Alto CA), Transdermal drug composition with dual permeation enhancers.
  38. Fahim Mostafa S. (500 Hulen Dr. Columbia MO 65201), Treatment of acne and skin disorders and compositions therefor.
  39. Greenfeld Albert R. (31430 Glenbridge Rd. Westlake Village CA 91361) Reis Herbert (Thousand Oaks CA) Tittmann Bernhard R. (Thousand Oaks CA), Ultrasonic self-cleaning catheter system for indwelling drains and medication supply.
  40. Lipkovker Lev M. (Bellevue WA), Ultrasonic transdermal drug delivery system.
  41. Kost Joseph (Omer MA ILX) Langer Robert S. (Somerville MA), Ultrasound enchancement of membrane permeability.
  42. Kost Joseph (Omer ILX) Levy Drora (Herzlia MA ILX) Langer Robert S. (Somerville MA), Ultrasound enhancement of transdermal drug delivery.
  43. Bommannan Durairaj (San Francisco CA) Okuyama Hirohisa (San Francisco CA) Guy Richard H. (San Francisco CA) Stauffer Paul (San Rafael CA) Flynn Gordon L. (Ann Arbor MI), Ultrasound-enhanced delivery of materials into and through the skin.
  44. Bommannan Durairaj (San Francisco CA) Okuyama Hirohisa (San Francisco CA) Guy Richard H. (San Francisco CA) Stauffer Paul (San Rafael CA) Flynn Gordon L. (Ann Arbor MI), Ultrasound-enhanced delivery of materials into and through the skin.
  45. Bommannan Durairaj (San Francisco CA) Okuyama Hirohisa (San Francisco CA) Guy Richard H. (San Francisco CA) Stauffer Paul (San Rafael CA) Flynn Gordon L. (Ann Arbor MI), Ultrasound-enhanced delivery of materials into and through the skin.

이 특허를 인용한 특허 (235)

  1. Lauten, Cecilia Leal; Rognvaldsson, Karen Sibylla; Fossheim, Sigrid L.; Nilssen, Esben A.; Evjen, Tove J., Acoustically sensitive drug delivery particles comprising non-lamellar forming lipids.
  2. Ramdas, Radhakrishnan; Karri, Kartik; Sharma, Chidella Venkata Krishna Mohan, Active transdermal drug delivery system and the method thereof.
  3. Cole, Jean-Pierre; Fennell, Martin J., Analyte monitoring device and methods.
  4. Drucker, Steven H.; Jin, Robert Y.; Funderburk, Jeffery V., Analyte monitoring device and methods of use.
  5. Drucker, Steven H.; Jin, Robert Y.; Funderburk, Jeffery V., Analyte monitoring device and methods of use.
  6. Heller, Adam; Drucker, Steven H.; Jin, Robert Y.; Funderburk, Jeffery V., Analyte monitoring device and methods of use.
  7. Heller, Adam; Drucker, Steven H.; Jin, Robert Y.; Funderburk, Jeffery V., Analyte monitoring device and methods of use.
  8. Heller, Adam; Drucker, Steven H.; Jin, Robert Y.; Funderburk, Jeffery V., Analyte monitoring device and methods of use.
  9. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
  10. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
  11. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
  12. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
  13. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
  14. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
  15. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
  16. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
  17. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
  18. Peyser, Thomas A.; Heller, Adam, Analyte monitoring device and methods of use.
  19. Peyser, Thomas; Heller, Adam, Analyte monitoring device and methods of use.
  20. Peyser, Thomas; Heller, Adam, Analyte monitoring device and methods of use.
  21. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
  22. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
  23. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
  24. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
  25. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
  26. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
  27. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
  28. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
  29. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
  30. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  31. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  32. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  33. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  34. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  35. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  36. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  37. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  38. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  39. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  40. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  41. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  42. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  43. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  44. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  45. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  46. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  47. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  48. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  49. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  50. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  51. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  52. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  53. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  54. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  55. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  56. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  57. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  58. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  59. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  60. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  61. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  62. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  63. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  64. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  65. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  66. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  67. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  68. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  69. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Behrad, Aria; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  70. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Behrad, Aria; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  71. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Behrad, Aria; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  72. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Behrad, Aria; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
  73. Wolpert, Howard; Heller, Adam, Analyte monitoring device and methods of use.
  74. Wolpert, Howard; Heller, Adam, Analyte monitoring device and methods of use.
  75. Sloan, Mark K.; Jennewine, R. Curtis, Analyte monitoring devices and methods therefor.
  76. Sloan, Mark K.; Jennewine, R. Curtis, Analyte monitoring devices and methods therefor.
  77. Sloan, Mark Kent; Jennewine, R. Curtis, Analyte monitoring devices and methods therefor.
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