초록 ▼

An oral pharmaceutical preparation containing a therapeutically effective amount of a salt of morphine for administration once daily is provided. The preparation contains particles which have a core containing a salt of morphine coated with a barrier layer. The barrier layer is formed from a coating

An oral pharmaceutical preparation containing a therapeutically effective amount of a salt of morphine for administration once daily is provided. The preparation contains particles which have a core containing a salt of morphine coated with a barrier layer. The barrier layer is formed from a coating liquid that contains at least one water insoluble barrier forming component selected from the group consisting of ethyl cellulose, copolymers of acrylic and methacrylic esters and natural or synthetic waxes, and a plasticizer. The mean serum concentration of morphine obtained is at least 50% of the maximum serum concentration during at least 12 hours after the administration of a single dose of the preparation.

대표청구항 ▼

[ We claim:] [1.] An oral pharmaceutical preparation containing a therapeutically effective amount of a salt of morphine for administration once daily which consists of at least 50 particles, each particle having a core containing a salt of morphine coated with a barrier layer, said barrier layer be

[ We claim:] [1.] An oral pharmaceutical preparation containing a therapeutically effective amount of a salt of morphine for administration once daily which consists of at least 50 particles, each particle having a core containing a salt of morphine coated with a barrier layer, said barrier layer being formed from a coating liquid containing at least one water insoluble barrier forming component selected from the group consisting of ethyl cellulose, copolymers of acrylic and methacrylic esters and natural or synthetic waxes, and a plasticizer, wherein said coating liquid is a solution, dispersion, suspension, emulsion or melt and wherein the mean serum concentration of morphine obtained is at least 50% of the maximum serum concentration during at least 12 hours after the administration of a single dose of said preparation.