초록 ▼

Devices for the generation of inhalable aerosols by extrusion through a porous membrane by a motor-driven cam assembly are disclosed. The device holds a drug formulation container in a drug release position. The package is comprised of a collapsible wall with an opening and a cover for the opening t

Devices for the generation of inhalable aerosols by extrusion through a porous membrane by a motor-driven cam assembly are disclosed. The device holds a drug formulation container in a drug release position. The package is comprised of a collapsible wall with an opening and a cover for the opening that includes a porous membrane having a plurality of pores therein with a diameter in the range of 0.5 to 6.0 microns. An electric motor in the device is powered by a battery to rotate a cam assembly having three cams. The first cam forces a clamping member (configured to correspond to the outer periphery of the container) against the periphery of the collapsible wall of the container, sealing the jointure of the collapsible wall to the cover of the container along the entire periphery, except for a small unsealed portion thereof. The second cam crushes the collapsible wall, forcing the contents of the container through the unsealed portion of the jointure. The third cam operates to move the empty container out of the drug release position, while moving a new container into position.

대표청구항 ▼

[ What is claimed is:] [1.] A device for delivering an aerosolized drug formulation for inhalation by a patient, the device comprisinga plurality of containers having therein a drug formulation, each container having a cover;a means for holding a first container in a drug release position;a means fo

[ What is claimed is:] [1.] A device for delivering an aerosolized drug formulation for inhalation by a patient, the device comprisinga plurality of containers having therein a drug formulation, each container having a cover;a means for holding a first container in a drug release position;a means for extruding the drug formulation from the first container into a channel, wherein the patient inhales the formulation from the channel; the means comprising a cam assembly, the cam assembly comprising a first cam shaft mechanically connected to a power source, and an extrusion cam, the extrusion cam connected to the first cam shaft, wherein the extrusion cam exerts pressure on a first container whereby the drug formulation is extruded from the first container;a clamping cam, wherein the clamping cam forces a clamping member against the cover of the first container; and,an advancement cam, wherein the advancement cam advances each of the plurality of containers into drug release position for extruding the drug formulation for inhalation by the patient.