초록 ▼

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

대표청구항 ▼

[ What is claimed is:] [1.] A substantially neutral ibuprofen containing alcoholic or aqueous alcoholic composition which comprises, on a weight basis, of the total composition:a therapeutically effective amount, in the range of from about 2 to 10% ibuprofen in the form of its pharmacologically acce

[ What is claimed is:] [1.] A substantially neutral ibuprofen containing alcoholic or aqueous alcoholic composition which comprises, on a weight basis, of the total composition:a therapeutically effective amount, in the range of from about 2 to 10% ibuprofen in the form of its pharmacologically acceptable salt;a skin penetration enhancing effective amount in the range of from about 4 to 15% of a C.sub.7 to C.sub.14 -hydrocarbyl substituted 1,3-dioxolane, 1,3-dioxane or acetal;0 to about 18% of glycol having from 3 to 6 carbon atoms;at least about 40% of volatile alcohol selected from the group consisting of ethanol, isopropanol and mixture thereof;0 to about 25% water;base to provide a pH in the range of from 6.5 to about 8, and,optionally, gelling agent effective to thicken the composition to avoid or minimize run-off when applied to the skin.