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Water soluble paclitaxel prodrugs 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-043/02
  • C07D-030/500
  • A61K-051/04
  • A61B-050/55
출원번호 US-0815104 (1997-03-11)
발명자 / 주소
  • Li Chun
  • Wallace Sidney
  • Yu Dong-Fang
  • Yang David J.
출원인 / 주소
  • PG-TXL Company, L. P.
대리인 / 주소
    Arnold White & Durkee
인용정보 피인용 횟수 : 253  인용 특허 : 13

초록 ▼

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatm

대표청구항 ▼

[ What is claimed is:] [1.] A pharmaceutical composition comprising a conjugate comprising an anti-tumor or drug conjugated to a water soluble polyglutamic acid polymer, wherein said polymer has a molecular weight of greater than or equal to about 5,000, wherein said drug is conjugated to said polym

이 특허에 인용된 특허 (13)

  1. Brem Henry (Lutherville MD) Langer Robert S. (Newton MA) Domb Abraham J. (Efrat ILX), Controlled local delivery of chemotherapeutic agents for treating solid tumors.
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  2. Anderson David C. (Seattle WA) Morgan ; Jr. A. Charles (Edmonds WA) Abrams Paul G. (Seattle WA) Fritzberg Alan R. (Edmonds WA) Nichols Everett J. (Seattle WA), Covalently-linked complexes and methods for enhanced cytotoxicity and imaging.
    상세보기
  3. Stella Valentino J. (Lawrence KS) Mathew Abraham E. (Lenexa KS), Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof.
    상세보기
  4. Gustavson Linda M. (Seattle WA) Fritzberg Alan R. (Edmonds WA), Directed biodistribution of radiolabelled biotin using carbohydrate polymers.
    상세보기
  5. Greenwald Richard B. (Somerset NJ) Pendri Annapurna (Matawan NJ), High molecular weight polymer-based prodrugs.
    상세보기
  6. Pastan Ira H. (Potomac MD), Monoclonal antibodies to prostate cells.
    상세보기
  7. Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
    상세보기
  8. Mongelli Nicola (Milan ITX) Angelucci Francesco (Milan ITX) Pesenti Enrico (Cologno Monzese ITX) Suarato Antonino (Milan ITX) Biasoli Giovanni (Gavirate ITX), Polymer-bound paclitaxel derivatives.
    상세보기
  9. Mongelli Nicola (Milan ITX) Angelucci Francesco (Milan ITX) Pesenti Enrico (Cologno Monzese ITX) Suarato Antonino (Milan ITX) Biasoli Giovanni (Gavirate ITX), Polymer-bound paclitaxel derivatives.
    상세보기
  10. Mongelli Nicola,ITX ; Angelucci Francesco,ITX ; Pesenti Enrico,ITX ; Suarato Antonino,ITX ; Biasoli Giovanni,ITX, Polymer-bound paclitaxel derivatives.
    상세보기
  11. Butterfield Dennis E. ; Fujii Dennis K. ; Ladd David L. ; Snow Robert A. ; Tan Julia S. ; Toner John L., Segmented chelating polymers as imaging and therapeutic agents.
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  12. Brahn Ernest (Encino CA), Use of taxol in the treatment of rheumatoid arthritis.
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  13. Desai Neil P. (Los Angeles CA) Soon-Shiong P. (Los Angeles CA) Sandford Paul A. (Los Angeles CA), Water-soluble polymeric carriers for drug delivery.
    상세보기

이 특허를 인용한 특허 (253)

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