$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색도움말
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"

통합검색

도움말도움말
상세검색 다국어 입력

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

특허 상세정보

MyON담기
내보내기 페이스북 공유 카카오톡 공유

Water soluble paclitaxel prodrugs

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A01N-043/02    C07D-030/500    A61K-051/04    A61B-050/55   
미국특허분류(USC) 514/449 ; 549/510 ; 549/511 ; 424/016.5 ; 424/093.6
출원번호 US-0815104 (1997-03-11)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Arnold White & Durkee
인용정보 피인용 횟수 : 253  인용 특허 : 13
초록

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis and for prediction of paclitaxel uptake by tumors and radiolabeled DTPA-paclitaxel tumor imaging. Other embodiments include the coating of implantable stents for prevention of restenosis.

대표
청구항

[ What is claimed is:] [1.] A pharmaceutical composition comprising a conjugate comprising an anti-tumor or drug conjugated to a water soluble polyglutamic acid polymer, wherein said polymer has a molecular weight of greater than or equal to about 5,000, wherein said drug is conjugated to said polymer so as to provide a drug conjugate having a higher water solubility than the unconjugated drug, the ability to accumulate in a tumor, and wherein said anti-tumor drug is paclitaxel, docetaxel, etopside, teniposide, camptothecin or epothilone.

이 특허에 인용된 특허 (13)

  1. Brem Henry (Lutherville MD) Langer Robert S. (Newton MA) Domb Abraham J. (Efrat ILX). Controlled local delivery of chemotherapeutic agents for treating solid tumors. USP1997055626862.
  2. Anderson David C. (Seattle WA) Morgan ; Jr. A. Charles (Edmonds WA) Abrams Paul G. (Seattle WA) Fritzberg Alan R. (Edmonds WA) Nichols Everett J. (Seattle WA). Covalently-linked complexes and methods for enhanced cytotoxicity and imaging. USP1992125169933.
  3. Stella Valentino J. (Lawrence KS) Mathew Abraham E. (Lenexa KS). Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof. USP1990104960790.
  4. Gustavson Linda M. (Seattle WA) Fritzberg Alan R. (Edmonds WA). Directed biodistribution of radiolabelled biotin using carbohydrate polymers. USP1997035607659.
  5. Greenwald Richard B. (Somerset NJ) Pendri Annapurna (Matawan NJ). High molecular weight polymer-based prodrugs. USP1997035614549.
  6. Pastan Ira H. (Potomac MD). Monoclonal antibodies to prostate cells. USP1996025489525.
  7. Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ). Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon. USP1993065219564.
  8. Mongelli Nicola (Milan ITX) Angelucci Francesco (Milan ITX) Pesenti Enrico (Cologno Monzese ITX) Suarato Antonino (Milan ITX) Biasoli Giovanni (Gavirate ITX). Polymer-bound paclitaxel derivatives. USP1994115362831.
  9. Mongelli Nicola (Milan ITX) Angelucci Francesco (Milan ITX) Pesenti Enrico (Cologno Monzese ITX) Suarato Antonino (Milan ITX) Biasoli Giovanni (Gavirate ITX). Polymer-bound paclitaxel derivatives. USP1996105569720.
  10. Mongelli Nicola,ITX ; Angelucci Francesco,ITX ; Pesenti Enrico,ITX ; Suarato Antonino,ITX ; Biasoli Giovanni,ITX. Polymer-bound paclitaxel derivatives. USP1998025719265.
  11. Butterfield Dennis E. ; Fujii Dennis K. ; Ladd David L. ; Snow Robert A. ; Tan Julia S. ; Toner John L.. Segmented chelating polymers as imaging and therapeutic agents. USP1998035730968.
  12. Brahn Ernest (Encino CA). Use of taxol in the treatment of rheumatoid arthritis. USP1996125583153.
  13. Desai Neil P. (Los Angeles CA) Soon-Shiong P. (Los Angeles CA) Sandford Paul A. (Los Angeles CA). Water-soluble polymeric carriers for drug delivery. USP1997075648506.

이 특허를 인용한 특허 피인용횟수: 253

  1. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Rob; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse resistant lysine amphetamine compounds. USP2010027662787.
  2. Mickle,Travis; Krishnan,Suma; Moncrief,James Scott; Lauderback,Christopher; Bishop,Barney; Oberlender,Rob; Piccariello,Thomas. Abuse resistant lysine amphetamine compounds. USP2007057223735.
  3. Mickle,Travis; Krishnan,Suma; Bishop,Barney; Lauderback,Christopher; Moncrief,James Scott; Oberlender,Rob; Piccariello,Thomas. Abuse-resistant amphetamine compounds. USP2006097105486.
  4. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010027659253.
  5. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010027659254.
  6. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010037678770.
  7. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010027655630.
  8. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010037687466.
  9. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010027662788.
  10. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010057713936.
  11. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010037671030.
  12. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010037674774.
  13. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010057723305.
  14. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010037687467.
  15. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010057718619.
  16. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010037678771.
  17. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010037671031.
  18. Mickle, Travis; Krishnan, Suma; Bishop, Barney; Lauderback, Christopher; Moncrief, James Scott; Oberlender, Robert; Piccariello, Thomas; Paul, Bernhard J.; Verbicky, Christopher A.. Abuse-resistant amphetamine prodrugs. USP2010047700561.
  19. Mickle,Travis; Krishnan,Suma; Moncrief,James Scott; Lauderback,Christopher; Miller,Christal. Abuse-resistant hydrocodone compounds. USP2008037338939.
  20. Mickle,Travis; Krishnan,Suma; Moncrief,James Scott; Mickle,Christal; Lauderback,Christopher; Piccariello,Thomas. Abuse-resistant hydrocodone compounds. USP2008057375082.
  21. Mickle, Travis; Krishnan, Suma; Moncrief, James Scott; Lauderback, Christopher; Piccariello, Thomas; Kirk, Randal. Active agent delivery systems and methods for protecting and administering active agents. USP2013038394813.
  22. Mickle,Travis; Krishnan,Suma; Moncrief,James Scott; Lauderback,Christopher; Piccariello,Thomas; Kirk,Randal. Active agent delivery systems and methods for protecting and administering active agents. USP2008097427600.
  23. Piccariello, Thomas; Olon, Lawrence P.; Kirk, Randall J.. Active agent delivery systems and methods for protecting and administering active agents. USP2004046716452.
  24. Piccariello,Thomas; Kirk,Randal J.; Mickle,Travis. Active agent delivery systems and methods for protecting and administering active agents. USP2006067060708.
  25. Falotico, Robert; Kopia, Gregory A.; Llanos, Gerard H.; Siekierka, John; Carter, Andrew J.. Antiinflammatory drug and delivery device. USP2004086776796.
  26. Hoffmann, Erika; Horres, Roland; Faust, Volker; Schreiber, Helmut; Von Holst, Armin; Hoffmann, Michael. Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis. USP2015119192697.
  27. Yang, David J.; Liu, Chun W.; Yu, Dong-Fang; Kim, E. Edmund. Bisaminoethanethiol-targeting ligand conjugates and compositions. USP2012088236279.
  28. McDonald,Donald M.; McLean,John W.; Thurston,O. Gavin. Cationic liposome delivery of taxanes to angiogenic blood vessels. USP2006097112338.
  29. McDonald,Donald M.; McLean,John W.; Thurston,O. Gavin. Cationic liposome delivery of taxanes to angiogenic blood vessels. USP2007077238369.
  30. Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D.. Coated implantable medical device. USP2013068469943.
  31. Bates, Brian L.; Ragheb, Anthony O.; Bourdeau, William J.; Fearnot, Neal E.. Coated medical device. USP2014038673387.
  32. Bates, Brian L.; Ragheb, Anthony O.; Stewart, IV, Joseph M.; Bourdeau, William J.; Choules, Brian D.; Purdy, James D.; Fearnot, Neal E.. Coated medical device. USP2015038974522.
  33. Bates, Brian L.; Ragheb, Anthony O.; Stewart, IV, Joseph M.; Bourdeau, William J.; Choules, Brian D.; Purdy, James D.; Fearnot, Neal E.. Coated medical device. USP2012058172793.
  34. Bates, Brian L.; Ragheb, Anthony O.; Stewart, IV, Joseph M.; Bourdeau, William J.; Choules, Brian D.; Purdy, James D.; Fearnot, Neal E.. Coated medical device. USP2017119814865.
  35. Bates, Brian L.; Ragheb, Anthony O.; Stewart, IV, Joseph M.; Bourdeau, William J.; Choules, Brian D.; Purdy, James D.; Fearnot, Neal E.. Coated medical device. USP2017079694162.
  36. Lentz, David Christian; Llanos, Gerard H.; Roller, Mark B.; Scopelianos, Angelo; Weadock, Kevin. Coated medical devices. USP2012118303609.
  37. Falotico,Robert; Spaltro,John. Coated medical devices for the treatment of vulnerable plaque. USP2007037195640.
  38. Horres, Roland; Hoffmann, Michael; Hoffmann, Erika; Linssen, Marita; Caspers, Roger; Styrnik, Michaela. Coating of the entire surface of endoprostheses. USP2014128916227.
  39. Owens, Michael Sean; Swee, Michael; Larson, Dennis; Blaskowsi, Stacie. Coating process for drug delivery balloons using heat-induced rewrap memory. USP2014118889211.
  40. Maneval, Daniel C.; Shepard, H. Michael; Thompson, Curtis B.. Combination therapy with an anti-hyaluronan agent and therapeutic agent. USP20181110137104.
  41. Maneval, Daniel C.; Shepard, H. Michael; Thompson, Curtis B.. Combination therapy with an anti-hyaluronan agent and therapeutic agent. USP2018039913822.
  42. Desai, Neil P.; Soon-Shiong, Patrick. Combinations and modes of administration of therapeutic agents and combination therapy. USP2015089101543.
  43. Desai, Neil P.; Soon-Shiong, Patrick. Combinations and modes of administration of therapeutic agents and combination therapy. USP2010077758891.
  44. Desai, Neil P.; Soon-Shiong, Patrick. Combinations and modes of administration of therapeutic agents and combination therapy. USP2012098268348.
  45. Desai, Neil P.; Soon-Shiong, Patrick. Combinations and modes of administration of therapeutic agents and combination therapy. USP2011108034375.
  46. Rothermel,John David; Schran,Horst F.; Greeley,Diane; Chen,TianLing. Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative. USP2006047030147.
  47. Hunter, William L.. Composition and methods of paclitaxel for treating psoriasis. USP2003026515016.
  48. Desai, Neil P.; Soon-Shiong, Patrick. Compositions and methods for administration of pharmacologically active compounds. USP2003036537579.
  49. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for biological remodeling with frozen particle compositions. USP2014058731842.
  50. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for biological remodeling with frozen particle compositions. USP2014078788212.
  51. Yang, David J.; Oh, Chang-Sok; Yu, Dong-Fang; Azhdarinia, Ali; Kohanim, Saady. Compositions and methods for cellular imaging and therapy. USP2014068758723.
  52. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for delivery of frozen particle adhesives. USP2015069056047.
  53. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for delivery of frozen particle adhesives. USP2015069050251.
  54. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for delivery of frozen particle adhesives. USP2015069060931.
  55. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A.. Compositions and methods for enhancing drug delivery across and into epithelial tissues. USP2003076593292.
  56. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A.. Compositions and methods for enhancing drug delivery across and into epithelial tissues. USP2003126669951.
  57. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A.. Compositions and methods for enhancing drug delivery across and into epithelial tissues. USP2004076759387.
  58. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A.. Compositions and methods for enhancing drug delivery across and into epithelial tissues. USP2014018623833.
  59. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, Leo P.; Sista, Lalitha V. S.; Kirschberg, Thorsten A.. Compositions and methods for enhancing drug delivery across and into ocular tissues. USP2014058729010.
  60. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A.. Compositions and methods for enhancing drug delivery across and into ocular tissues. USP2012108278264.
  61. Rothbard,Jonathan B.; Wender,Paul A.; McGrane,P. Leo; Sista,Lalitha V. S.; Kirschberg,Thorsten A.. Compositions and methods for enhancing drug delivery across and into ocular tissues. USP2007067229961.
  62. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for surface abrasion with frozen particles. USP2015079072799.
  63. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for surface abrasion with frozen particles. USP2014058721583.
  64. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for surface abrasion with frozen particles. USP2014058725420.
  65. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for surface abrasion with frozen particles. USP2015069050070.
  66. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for surface abrasion with frozen particles. USP2015069060934.
  67. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for surface abrasion with frozen particles. USP2014058722068.
  68. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for therapeutic delivery with frozen particles. USP2015079072688.
  69. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for therapeutic delivery with frozen particles. USP2015069050317.
  70. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for therapeutic delivery with frozen particles. USP2014058731840.
  71. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for therapeutic delivery with frozen particles. USP2015069060926.
  72. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for therapeutic delivery with frozen particles. USP2014078793075.
  73. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for therapeutic delivery with frozen particles. USP2014058731841.
  74. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A.. Compositions and methods for treating inflammatory diseases of the skin. USP2004056730293.
  75. Hunter, William L.. Compositions and methods for treating surgical adhesions. USP2004026689803.
  76. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong. Compositions and methods of delivery of pharmacological agents. USP2012118314156.
  77. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong. Compositions and methods of delivery of pharmacological agents. USP2014098846771.
  78. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong. Compositions and methods of delivery of pharmacological agents. USP2015049012518.
  79. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong. Compositions and methods of delivery of pharmacological agents. USP2010107820788.
  80. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong. Compositions and methods of delivery of pharmacological agents. USP2015049012519.
  81. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong. Compositions and methods of delivery of pharmacological agents. USP2012038138229.
  82. Macdonald, R. Loch. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage. USP20181010092524.
  83. Van, Sang; Song, Yucheng; Wang, Xinghe; Hou, Zheng; Feng, Zhongling; Zhao, Gang; Yu, Lei. Compositions that include a hydrophobic compound and a polyamino acid conjugate. USP2012068197828.
  84. Van, Sang; Song, Yucheng; Wang, Xinghe; Hou, Zheng; Feng, Zhongling; Zhao, Gang; Yu, Lei. Compositions that include a hydrophobic compound and a polyamino acid conjugate. USP2012128329199.
  85. Mickle,Travis; Krishnan,Suma; Moncrief,James Scott; Lauderback,Christopher; Bera,Sanjib; Guenther,Sven; Hirschelman,Wendy. Compounds and compositions for prevention of overdose of oxycodone. USP2007017169752.
  86. Moncrief, James Scott; Krishnan, Suma; Mickle, Travis; Lauderback, Christopher; Bera, Sanjib; Guenther, Sven; Hirschelman, Wendy. Compounds and compositions for prevention of overdose of oxycodone. USP2012018106016.
  87. Eichner, Wolfram; Schimmel, Martin; Hacket, Frank; Kraus, Elmar; Zander, Norbert; Frank, Ronald; Conradt, Harald; Langer, Klaus; Orlando, Michele; Sommermeyer, Klaus. Conjugates of hydroxyalkyl starch and a protein. USP2014098840879.
  88. Eichner, Wolfram; Schimmel, Martin; Hacket, Frank; Kraus, Elmar; Zander, Norbert; Frank, Ronald; Conradt, Harald; Langer, Klaus; Orlando, Michele; Sommermeyer, Klaus. Conjugates of hydroxyalkyl starch and a protein. USP2011098017739.
  89. Eichner, Wolfram; Orlando, Michele; Zander, Norbert; Conradt, Harald S.; Hacket, Frank; Langer, Klaus; Frank, Ronald. Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination. USP2012108287850.
  90. Orlando, Michele; Hemberger, Jurgen; Sommermeyer, Klaus; Eichner, Wolfram; Frie, Sven; Lutterbeck, Katharina; Jungheinrich, Cornelius; Scharpf, Roland. Coupling low-molecular substances to a modified polysaccharide. USP2013068466277.
  91. Hemberger, Jurgen; Orlando, Michele; Sommermeyer, Klaus; Eichner, Wolfram; Frie, Sven; Lutterbeck, Katharina; Jungheinrich, Cornelius; Scharpf, Roland. Coupling proteins to a modified polysaccharide. USP2014128916518.
  92. Li,Chun; Tansey,Wayne; Charnsangavej,Chusilp; Wallace,Sidney. Dendritic poly (amino acid) carriers and methods of use. USP2007087261875.
  93. Brekke, John H.; Gubbe, John H.. Device and methods for sequential, regional delivery of multiple cytotoxic agents and directed assembly of wound repair tissues. USP2012118314084.
  94. Brekke,John H.; Gubbe,John H.. Device and methods for sequential, regional delivery of multiple cytotoxic agents and directed assembly of wound repair tissues. USP2008027326421.
  95. Niitsu, Yoshiro; Yu, Lei; Liu, Jian; Zhao, Gang; Ma, Nianchun; Van, Sang. Drug carriers. USP2011088003621.
  96. Evens,Carl J.; Weedock,Kevin. Drug releasing anastomosis devices and methods for treating anastomotic sites. USP2006097108701.
  97. Wang, Lixiao. Drug releasing coatings for balloon catheters. USP2017079700704.
  98. Wang, Lixiao. Drug releasing coatings for balloon catheters. USP2017089737691.
  99. Wang, Lixiao. Drug releasing coatings for balloon catheters. USP2016049314598.
  100. Wang, Lixiao. Drug releasing coatings for balloon catheters. USP2015048998846.
  101. Wang, Lixiao. Drug releasing coatings for medical devices. USP2013028366660.
  102. Wang, Lixiao. Drug releasing coatings for medical devices. USP2013038403910.
  103. Wang, Lixiao. Drug releasing coatings for medical devices. USP2013038404300.
  104. Wang, Lixiao. Drug releasing coatings for medical devices. USP2013028366662.
  105. Wang, Lixiao. Drug releasing coatings for medical devices. USP2017099764065.
  106. Wang, Lixiao. Drug releasing coatings for medical devices. USP2017099757544.
  107. Wang, Lixiao. Drug releasing coatings for medical devices. USP2013048414525.
  108. Wang, Lixiao. Drug releasing coatings for medical devices. USP2017089737640.
  109. Wang, Lixiao. Drug releasing coatings for medical devices. USP2016039283358.
  110. Wang, Lixiao. Drug releasing coatings for medical devices. USP2016039289539.
  111. Wang, Lixiao. Drug releasing coatings for medical devices. USP2016049314552.
  112. Wang, Lixiao. Drug releasing coatings for medical devices. USP2013048414910.
  113. Wang, Lixiao. Drug releasing coatings for medical devices. USP2015059023371.
  114. Wang, Lixiao. Drug releasing coatings for medical devices. USP2015049005161.
  115. Wang, Lixiao. Drug releasing coatings for medical devices. USP2015048998847.
  116. Wang, Lixiao. Drug releasing coatings for medical devices. USP2013048414909.
  117. Falotico, Robert; Siekierka, John; Llanos, Gerard H.; Kopia, Gregory A.; Carter, Andrew J.. Drug/drug delivery systems for the prevention and treatment of vascular disease. USP2012088236048.
  118. Falotico,Robert; Kopia,Gregory A.; Llanos,Gerard H.. Drug/drug delivery systems for the prevention and treatment of vascular disease. USP2007117300662.
  119. Yang, David J.; Liu, Chun W.; Yu, Dong Fang; Kim, E. Edmund. Ethylenedicysteine (EC)-drug conjugates compositions and methods for tissue specific disease imaging. USP2009097582281.
  120. Yang, David J.; Liu, Chun W.; Yu, Dong Fang; Kim, E. Edmund. Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging. USP2009127632484.
  121. Yang, David J.; Liu, Chun W.; Yu, Dong-Fang; Kim, E. Edmond. Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging. USP2004026692724.
  122. Yang,David J.; Liu,Chun W.; Yu,Dong Fang; Kim,E. Edmund. Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging. USP2007067229604.
  123. Yang,David J.; Liu,Chun W.; Yu,Dong Fang; Kim,E. Edmund. Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging. USP2007057223380.
  124. Yang,David J.; Liu,Chun W.; Yu,Dong Fang; Kim,E. Edmund. Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging. USP2006067067111.
  125. Ehrenreich, Kevin J.; Newhauser, Richard R.; von Oepen, Randolf; Stankus, John. Expandable member formed of a fibrous matrix for intraluminal drug delivery. USP2011128076529.
  126. Ehrenreich, Kevin J.; Newhauser, Richard R.; von Oepen, Randolf; Stankus, John. Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery. USP2011118049061.
  127. Von Oepen, Randolf; Stankus, John; Stamberg, Barbara; Yribarren, Travis R.; Newhauser, Richard R.. Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery. USP2012078226603.
  128. Desai, Neil P.; Soon-Shiong, Patrick. Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof. USP2014108853260.
  129. Desai, Neil P.; Tao, Chunlin; Yang, Andrew; Louie, Leslie; Soon-Shiong, Patrick. Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof. USP2012038137684.
  130. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Frozen compositions and array devices thereof. USP2014078784384.
  131. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Frozen compositions and methods for piercing a substrate. USP2014088798932.
  132. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Frozen compositions and methods for piercing a substrate. USP2015059040087.
  133. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Frozen compositions and methods for piercing a substrate. USP2014088798933.
  134. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Frozen compositions and methods for piercing a substrate. USP2014108858912.
  135. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Frozen piercing implements and methods for piercing a substrate. USP2014078784385.
  136. Conradt, Harald S.; Grabenhorst, Eckart; Nimtz, Manfred; Zander, Norbert; Frank, Ronald; Eichner, Wolfram. Hasylated polypeptides. USP2013128618266.
  137. Nho, Kwang; Chang-min, Hyun; Lee, Jung-Hun; Kim, In-Kyung; Pak, Young-Kyoung. Hexa-arm polyethylene glycol and its derivatives and the methods of preparation thereof. USP2005026858736.
  138. Bartis, Judit; Volckova, Erika; Tandon, Manish; Lowe, Deirdre; Redmon, Martin P.. Hydroxy sulfonate of quinone compounds and their uses. USP2010097790765.
  139. Zander, Norbert; Conradt, Harald; Eichner, Wolfram. Hydroxyalkyl starch derivatives. USP2013078475765.
  140. Kramer-Brown, Pamela A.; Ludwig, Florian. Implantable medical devices for local and regional treatment. USP2012088252361.
  141. McManus, Samuel P.; Kozlowski, Antoni; Hutchison, Tracy L.; Bray, Brian; Shen, Xiaoming. Intermediates useful in the preparation of maleimide functionalized polymers. USP2014118895759.
  142. McManus, Samuel P.; Kozlowski, Antoni; Hutchison, Tracy L.; Bray, Brian; Shen, Xiaoming. Intermediates useful in the preparation of maleimide functionalized polymers. USP2012098258324.
  143. McManus, Samuel P.; Kozlowski, Antoni; Hutchison, Tracy L.; Bray, Brian; Shen, Xiaoming. Intermediates useful in the preparation of maleimide functionalized polymers. USP2014028653286.
  144. McManus, Samuel P.; Kozlowski, Antoni; Hutchison, Tracy L.; Bray, Brian; Shen, Xiaoming. Intermediates useful in the preparation of maleimide functionalized polymers. USP2011108039579.
  145. Macdonald, R. Loch; Leuthner, Brian A.. Intraventricular drug delivery system for improving outcome after a brain injury affecting cerebral blood flow. USP2016069364432.
  146. Piccariello,Thomas; Olon,Lawrence Peter; Goldstein,Alex Saunders; Moncrief,James Scott; Boerth,Nancy Johnston. Iodothyronine compositions. USP2007017163918.
  147. Barry James J. ; Palasis Maria. Loading and release of water-insoluble drugs. USP2001106306166.
  148. Falotico,Robert; Llanos,Gerard H.. Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent. USP2007067229473.
  149. Falotico,Robert; Llanos,Gerard H.. Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent. USP2007057217286.
  150. Wright,Carol; Llanos,Gerard H.; Rakos,Ronald; King,Kristin; Falotico,Robert. Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent. USP2007057223286.
  151. Simeon M. Wrenn, Jr.. Local delivery of therapeutic agents. USP2002116485514.
  152. Llanos,Gerard H.; Lentz,David Christian. Local drug delivery devices and methods for maintaining the drug coatings thereon. USP2007087261735.
  153. Yang,David J.; Yu,Dong Fang; Azhdarinia,Ali; Lee,Tommy L.; Kim,E. Edmund. Local regional chemotherapy and radiotherapy using in situ hydrogel. USP2006037008633.
  154. Kumar,Anil M.; Klein,J. Peter; Bhatt,Rama; Vawter,Edward. Manufacture of polyglutamate-therapeutic agent conjugates. USP2008077399860.
  155. Speck, Ulrich; Scheller, Bruno. Medical device for dispensing medicaments. USP2012098257305.
  156. Speck, Ulrich; Scheller, Bruno. Medical device for dispersing medicaments. USP2015129216272.
  157. Speck, Ulrich; Scheller, Bruno. Medical device for dispersing medicaments. USP2015129216273.
  158. Speck, Ulrich; Scheller, Bruno. Medical device for dispersing medicaments. USP2017059649476.
  159. Speck, Ulrich; Scheller, Bruno. Medical device for dispersing medicaments. USP2017069687635.
  160. Speck, Ulrich; Scheller, Bruno. Medical device for dispersing medicaments. USP2016049302080.
  161. Speck, Ulrich; Scheller, Bruno. Medical device for dispersing medicaments. USP2013058439868.
  162. Wang, Lixiao. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent. USP2017079694111.
  163. Wang, Lixiao. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent. USP2013048425459.
  164. Wang, Lixiao. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent. USP2016029248220.
  165. Wang, Lixiao. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent. USP2015018932561.
  166. Wang, Lixiao. Medical device rapid drug releasing coatings comprising oils, fatty acids and/or lipids. USP2017099757351.
  167. Wang, Lixiao. Medical device rapid drug releasing coatings comprising oils, fatty acids and/or lipids. USP2016039289537.
  168. Wang, Lixiao. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids. USP2013048414526.
  169. Wang, Lixiao. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids. USP2015059033919.
  170. Kangas, Steve; Feng, James; Chen, Yen-Lane; Zeng, Maggie. Medical device with crystalline drug coating. USP2015069056152.
  171. Paul, Ram H.; Sirota, Daniel J.; Amarant, Paul D.. Medical device with therapeutic agents. USP2010087780647.
  172. Atanasoska, Liliana; Weber, Jan; Shippy, III, James Lee. Medical devices having multiple charged layers. USP2014098834912.
  173. Davila,Luis A.; Lentz,David Christian; Llanos,Gerard H.; Mendez,Jorge Orlando; Narayanan,Pallassana V.; Pelton,Alan Roy; Roller,Mark B.; Scheidt,Karl K.; Scopelianos,Angelo George; Shaw, Jr.,William . Medical devices, drug coatings and methods for maintaining the drug coatings thereon. USP2006067056550.
  174. Hoffmann, Erika; Horres, Roland; Faust, Volker; Schreiber, Helmut; Von Holst, Armin; Hoffmann, Michael. Medical product for treating stenosis of body passages and for preventing threatening restenosis. USP2013128597720.
  175. Whitbourne, Richard J.; Chamberlain, Alexandra M.; Hullihen, Daniel G.; Rosebrough, Scott F.; Calistri-Yeh, Mildred. Medicated stent having multi-layer polymer coating. USP2010087771468.
  176. Whitbourne, Richard J.; Chamberlain, Alexandra M.; Hullihen, Daniel G.; Rosebrough, Scott F.; Calistri-Yeh, Mildred. Medicated stent having multi-layer polymer coating. USP2012108287590.
  177. Yang, David J.; Liu, Chun W.; Yu, Dong Fang; Kim, E. Edmund. Metal ion-labeled bis-aminoethanethiol-targeting ligand conjugates, compositions, and methods for tissue-specific disease imaging. USP2009117615208.
  178. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition. USP2014078788211.
  179. KenKnight Bruce H. ; Warren Jay A. ; Hahn Stephen John. Method and system for reducing arterial restenosis in the presence of an intravascular stent. USP2001116317615.
  180. KenKnight, Bruce H.; Warren, Jay A.; Hahn, Stephen John. Method and system for reducing arterial restenosis in the presence of an intravascular stent. USP2003026519488.
  181. Kozlowski, Antoni; Handley, John; Schaefer, Anthony G.; Bray, Brian; Odom, Ryan; Sander, Tony L.. Method for preparing conjugates using polymer maleimides. USP2011118058385.
  182. Kozlowski, Antoni; Handley, John R.; Schaefer, Anthony G.; Bray, Brian; Odom, Ryan; Sander, Tony L.. Method for preparing polymer maleimides. USP2012078227558.
  183. Kozlowski, Antoni; Handley, John; Schaefer, Anthony G.; Bray, Brian; Odom, Ryan; Sander, Tony L.. Method for preparing polymer maleimides. USP2011017872082.
  184. KenKnight, Bruce H.; Warren, Jay A.; Hahn, Stephen John. Method for reducing arterial restenosis in the presence of an intravascular stent. USP2003116648881.
  185. KenKnight, Bruce H.; Warren, Jay A.; Hahn, Stephen John. Method for reducing restenosis in the presence of an intravascular stent. USP2005096939345.
  186. Johnson, Jr., Robert; Zhou, Yiqing; Müller, Thomas. Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics. USP2010047691838.
  187. William L. Hunter CA. Method for treating multiple sclerosis. USP2002126495579.
  188. McManus, Samuel P.; Kozlowski, Antoni; Hutchison, Tracy L.; Bray, Brian; Shen, Xiaoming. Method of preparing maleimide functionalized polymers. USP2010097790835.
  189. Kawai,Keiichi; Takamura,Norito; Nishii,Ryuichi. Method of the administration of drugs having binding affinity with plasma protein and preparation to be used in the method. USP2006047029653.
  190. Ragheb,Anthony O.; Fearnot,Neal E.; Voorhees, III,William D.; Kozma,Thomas G.; Bates,Brian L.; Osborne,Thomas A.. Method of treating a patient with a coated implantable medical device. USP2008117445628.
  191. Wang, Jeffrey; Malinoff, Harrison; Wang, Lixiao; Barry, Christopher M.; Wahr, Dennis W.; Naisbitt, Scott R.. Methods and apparatuses for coating balloon catheters. USP2013048430055.
  192. Wang, Jeffrey; Malinoff, Harrison; Wang, Lixiao; Barry, Christopher M.; Wahr, Dennis W.; Naisbitt, Scott R.. Methods and apparatuses for coating balloon catheters. USP2015119180485.
  193. Wang, Jeffrey; Malinoff, Harrison; Wang, Lixiao; Barry, Christopher M.; Wahr, Dennis W.; Naisbitt, Scott R.. Methods and apparatuses for coating balloon catheters. USP2017099770576.
  194. Phan, Loc; Roschak, Ed. Methods and devices for maintaining patency of surgically created channels in a body organ. USP2010057708712.
  195. Desai, Neil P.; Soon-Shiong, Patrick. Methods and formulations of cremophor-free taxanes. USP2003016506405.
  196. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data. USP2014068762067.
  197. Zeng, Maggie; Chen, Yen-Lane; Romanshek, Maura; Meyer, Erin. Methods of converting amorphous drug substance into crystalline form. USP2014038669360.
  198. Kleiner, Lothar Walter; DesNoyer, Jessica Renee; Pacetti, Stephen Dirk; Hossainy, Syed Faiyaz Ahmed; Trollsas, O. Mikael; Ngo, Michael Huy. Methods of forming Poly(ester amide)-based drug delivery systems with controlled release rate and morphology. USP2013028377499.
  199. Desai, Neil P.; Soon-Shiong, Patrick. Methods of treating cancer. USP2016079393318.
  200. Desai, Neil P.; Soon-Shiong, Patrick. Methods of treating cancer. USP2017039597409.
  201. Desai, Neil P.; Soon-Shiong, Patrick. Methods of treatment of pancreatic cancer. USP2017119820949.
  202. Desai, Neil P.; Soon-Shiong, Patrick. Methods of treatment of pancreatic cancer. USP2016079399071.
  203. Desai, Neil P.; Soon-Shiong, Patrick. Methods of treatment of pancreatic cancer. USP2016079399072.
  204. Yang, David J.; Yu, Dong-Fang; Oh, Chang-Sok; Bryant, Jr., Jerry L.. N2S2 chelate-targeting ligand conjugates. USP2015069050378.
  205. Garvey, David S.; Letts, L. Gordon; Lin, Chia-En; Richardson, Stewart K.; Wang, Tiansheng. Nitrosated and nitrosylated taxanes, compositions and methods of use. USP2005036869973.
  206. Garvey, David S.; Letts, L. Gordon; Lin, Chia-En; Richardson, Stewart K.; Wang, Tiansheng. Nitrosated and nitrosylated taxanes, compositions and methods of use. USP2003126656966.
  207. Kangas, Steve; Owens, Michael Sean; Patterson, Jon; Ekberg, Dave; Haun, Erik; Henderson, Eric; Foss, Aaron; Chen, Yen-Lane. Nucleation of drug delivery balloons to provide improved crystal size and density. USP20180910080821.
  208. Barry, James J.; Kamath, Kalpana R.. Optimized dosing for drug coated stents. USP2005066908622.
  209. van Hoogevest, Peter. Organic compounds. USP2004016683100.
  210. Desai, Neil P.; Soon-Shiong, Patrick. Paclitaxel-containing formulations. USP2004066753006.
  211. Bandyopadhyay, Rebanta; Malloy, Timothy M.; Panaggio, Andrea; Raghavan, Krishnaswamy Srinivas; Varia, Sailesh Amilal. Parenteral formulation for epothilone analogs. USP2014018632788.
  212. Bandyopadhyay,Rebanta; Malloy,Timothy M.; Panaggio,Andrea; Raghavan,Krishnaswamy Srinivas; Varia,Sailesh Amilal. Parenteral formulation for epothilone analogs. USP2006047022330.
  213. Kirk,Randal J.; Latham,Keith R.. Pharmaceutical composition containing an active agent in an amino acid copolymer structure. USP2006037018654.
  214. Mickle, Travis; Krishnan, Suma; Moncrief, James Scott; Lauderback, Christopher. Pharmaceutical compositions for prevention of overdose or abuse. USP2013018343927.
  215. Mickle,Travis; Krishnan,Suma; Moncrief,James Scott; Lauderback,Christopher; Mickle,Christal. Pharmaceutical compositions for prevention of overdose or abuse. USP2008057375083.
  216. Ashwell, Mark A.; Li, Chiang J.; Tandon, Manish; Liu, Yanbin; LaPierre, Jean-Marc; Jiang, Zhiwei. Pharmaceutical compositions of β-lapachone and β-lapachone analogs with improved tumor targeting potential. USP2010107812051.
  217. Bandyopadhyay, Rebanta; Malloy, Timothy M.; Panaggio, Andrea; Raghavan, Krishnaswamy Srinivas; Varia, Sailesh Amilal. Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones. USP2003066576651.
  218. Bandyopadhyay,Rebanta; Malloy,Timothy M.; Panaggio,Andrea; Raghavan,Krishnaswamy Srinivas; Varia,Sailesh Amilal; Cohen,Marvin Barry. Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones. USP200806RE40387.
  219. Kleiner, Lothar Walter; DesNoyer, Jessica Reneé; Pacetti, Stephen Dirk; Hossainy, Syed Faiyaz Ahmed; Trollsas, O. Mikael; Ngo, Michael Huy. Poly(ester amide)-based drug delivery systems. USP2014108865189.
  220. Kleiner, Lothar Walter; DesNoyer, Jessica Renee; Pacetti, Stephen Dirk; Hossainy, Syed Faiyaz Ahmed. Poly(ester amide)-based drug delivery systems with controlled release rate and morphology. USP2013028377107.
  221. Kleiner, Lothar Walter; DesNoyer, Jessica Renee; Pacetti, Stephen Dirk; Hossainy, Syed Faiyaz Ahmed. Poly(ester amide)-based drug delivery systems with controlled release rate and morphology. USP2013038389044.
  222. Yu, Lei; Zhao, Gang; Van, Sang; Das, Sanjib Kumar; Feng, Zhongling; Fu, Xiaoli; Wang, Xinghe; Jin, Yi; Chen, Fu. Polyglutamate-amino acid conjugates and methods. USP2018019855338.
  223. Bhatt,Rama; Vries,Peter de; Klein,J. Peter; Tulinsky,John; Lewis,Robert A.; Singer,Jack W.. Polyglutamic acid-camptothecin conjugates and methods of preparation. USP2007027173041.
  224. Bhatt,Rama; Vries,Peter de; Klein,J. Peter; Tulinsky,John; Lewis,Robert A.; Singer,Jack W.. Polyglutamic acid-camptothecin conjugates and methods of preparation. USP2006127153864.
  225. Kraus, Werner; Hocker, Hartwig; Lahann, Jorg; Klee, Doris. Polymer-coated stents, processes for producing the same and their use for restenosis prevention. USP2004036712846.
  226. Macdonald, R. Loch; Davis, Cara R.; Burton, Kevin; Winchester, Gary; Stella, Angela R.. Polymorph compositions, methods of making, and uses thereof. USP2014098821944.
  227. Macdonald, R. Loch; Davis, Cara R.; Burton, Kevin; Winchester, Gary; Stella, Angela R.; Heshmati, Parissa. Polymorph compositions, methods of making, and uses thereof. USP2016079399019.
  228. Speck, Ulrich; Scheller, Bruno. Preparation for restenosis prevention. USP2015069066990.
  229. Speck, Ulrich; Scheller, Bruno. Preparation for restenosis prevention. USP2013038389043.
  230. Speck, Ulrich; Scheller, Brunn. Preparation for the prophylaxis of restenosis. USP2010077750041.
  231. Nho, Kwang; Hyun, Changmin; Lee, Junghun; Pak, Youngkyoung. Preparation method of peg-maleimide derivatives. USP2004126828401.
  232. Desai, Neil P.; Tao, Chunlin; Yang, Andrew; Louie, Leslie; Yao, Zhiwen; Soon-Shiong, Patrick; Magdassi, Shlomo. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof. USP2004066749868.
  233. Ashwell, Mark A.; Tandon, Manish; Lapierre, Jean-Marc; Liu, Yanbin. Quinone prodrug compositions and methods of use. USP2013128614228.
  234. Kyung Bae Park KR. Radioactive balloon for dilation catheter system and process for preparation thereof. USP2002106461666.
  235. Rosenthal, David; Gannon, Brian. Radioactive medical devices and methods of making radioactive medical devices. USP2003096612976.
  236. Rosenthal, David; Gannon, Brian. Radioactive medical devices for inhibiting a hyperplastic response and method of making radioactive medical devices. USP2003096616592.
  237. Chan, Albert; Oelsner, Stephen M.; Simpson, Thomas J.; Corrent, Sonia. Radioactively coated devices. USP2004016676988.
  238. Antonio A. Albano ; Wantanee Phuapradit ; Harpreet K. Sandhu ; Navnit Hargovindas Shah. Stable complexes of poorly soluble compounds in ionic polymers. USP2002026350786.
  239. Yang Dachuan ; Stanslaski Joel L. ; Wang Lixiao ; Smith Scott R.. Stent coating. USP2001076258121.
  240. Yang, Dachuan; Stanslaski, Joel L.; Wang, Lixiao; Smith, Scott R.. Stent coating. USP2003056569195.
  241. Ehrenreich, Kevin J.; Newhauser, Richard; von Oepen, Randolf; Stankus, John. Stent delivery system having a fibrous matrix covering with improved stent retention. USP2013088500687.
  242. Ehrenreich, Kevin J.; Newhauser, Richard; von Oepen, Randolf; Stankus, John J.. Stent delivery system having a fibrous matrix covering with improved stent retention. USP2017089730820.
  243. Mickle, Travis; Krishnan, Suma; Moncrief, James Scott; Lauderback, Christopher; Piccariello, Thomas. Sustained release pharmaceutical compounds to prevent abuse of controlled substances. USP2009117622441.
  244. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Systems, devices, and methods for making or administering frozen particles. USP2014098849441.
  245. Whitbourne, Richard J.; Hullihen, Daniel; Violante, Michael R.; Wang, Frank Guo-Bin; Zhang, Xianping. Targeted therapeutic agent release devices and methods of making and using the same. USP2012018101200.
  246. De Luca, Gilda; Bettolo, Rinaldo Marini; Migneco, Luisa Maria. Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives. USP2011108034795.
  247. De Luca, Gilda; Bettolo, Rinaldo Marini; Migneco, Luisa Maria. Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives. USP2011037897584.
  248. Wang, Lixiao. Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs. USP2018049937159.
  249. Wang, Lixiao. Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs. USP2016089402935.
  250. Li,Chun; Wallace,Sidney; Yu,Dong Fang; Yang,David. Water soluble paclitaxel derivatives. USP2006117135496.
  251. Li,Chun; Wallace,Sidney; Yu,Dong Fang; Yang,David J.. Water soluble paclitaxel derivatives. USP2006067060724.
  252. Li,Chun; Wallace,Sidney; Yu,Dong Fang; Yang,David J.. Water soluble paclitaxel prodrugs. USP2008067384977.
  253. Ji, Shishan; Zhu, Dequan. Y shape branched hydrophilic polymer derivatives, their preparation methods, conjugates of the derivatives and drug molecules, and pharmaceutical compositions comprising the conjugates. USP2011088003089.

IPC 상위 출원인