초록 ▼

A method of transdermally or transmucosally delivering a hydrophilic salt form of a drug with a water-based pressure sensitive hydrophobic adhesive matrix patch optionally containing a permeation enhancer is disclosed. A matrix patch comprising a water-based pressure sensitive hydrophobic adhesive,

A method of transdermally or transmucosally delivering a hydrophilic salt form of a drug with a water-based pressure sensitive hydrophobic adhesive matrix patch optionally containing a permeation enhancer is disclosed. A matrix patch comprising a water-based pressure sensitive hydrophobic adhesive, a hydrophilic salt form of a drug, and optionally a permeation enhancer for transdermal or transmucosal delivery of the hydrophilic salt form of the drug is also disclosed.

대표청구항 ▼

[ We claim:] [1.] A method of transdermally delivering a hydrophilic salt form of a drug comprising the steps of:(a) providing a pressure sensitive adhesive matrix patch device comprising(i) a drug-containing adhesive matrix layer comprising a water-based polyisobutylene adhesive having dissolved th

[ We claim:] [1.] A method of transdermally delivering a hydrophilic salt form of a drug comprising the steps of:(a) providing a pressure sensitive adhesive matrix patch device comprising(i) a drug-containing adhesive matrix layer comprising a water-based polyisobutylene adhesive having dissolved therein an effective amount of said hydrophilic salt form of said drug, wherein said hydrophilic salt form of said drug is selected from the group consisting of diclofenac sodium, sodium cromolyn, sodium acyclovir, sodium ampicillin, ketorolac tromethamine, amiloride HCl, ephedrine HCl, loxapine HCl, thiothixene HCl, trifluoperizine HCl, naltrexone HCl, naloxone HCl, nalbuphine HCl, buspirone HCl, bupriprion HCl, phenylephrine HCl, tolazoline HCl, chlorpheniramine maleate, phenylpropanolamine HCl, clonidine HCl, dextromethorphan HBr, metoprolol succinate, metoprolol tartrate, epinephrine bitartrate, ketotofin fumarate, atropine sulfate, fentanyl citrate, apomorphine sulfate, propranolol HCl, pindolol HCl, lidocaine HCl, tetracycline HCl, oxytetracycline HCl, tetracaine HCl, dibucaine HCl, terbutaline sulfate, scopolamine HBr, and brompheniramine maleate, and optionally an effective amount of a permeation enhancer, a proximal surface of said layer adapted to adhere to the skin and a distal surface of said layer adapted to adhere to a backing layer, and(ii) a backing layer that is substantially impermeable to said drug laminated to said distal surface; and(b) contacting a selected area of the skin with said matrix patch device such that said proximal surface of said drug-containing adhesive matrix layer adheres to and is in drug transfer relationship with said selected area of the skin.