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Composition and method of enhancing electrotransport agent delivery 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/08
출원번호 US-0431187 (1995-04-28)
발명자 / 주소
  • Gyory J. Richard
  • Campbell Patricia S.
출원인 / 주소
  • ALZA Corporation
대리인 / 주소
    Miller
인용정보 피인용 횟수 : 44  인용 특허 : 48

초록 ▼

A composition suitable for transdermal electrotransport delivery of an agent through a body surface comprises a free acid/base form of an agent to be delivered by transdermal electrotransport, and a salt form of the agent, and optionally a permeation enhancer. Methods of enhancing transdermal electr

대표청구항 ▼

[ We claim:] [1.] An anodic donor reservoir composition comprising:a solution of the acid addition salt of a base therapeutic agent wherein the pH of said solution has been adjusted to within a predetermined range by the addition of base therapeutic agent and wherein the water content is at least ab

이 특허에 인용된 특허 (48)

  1. Spevak Richard (Minneapolis MN) Lattin Gary A. (Forest Lake MN) Jevne Allan H. (Anoka MN), Apparatus and method for iontophoretic drug delivery.
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  2. Sage ; Jr. Burton H. (Raleigh NC), Apparatus for an electrode used for iontophoresis.
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  3. Bodor Nicholas S. (Gainesville FL) Loftsson Thorsteinn (Reykjavik ISX), Composition and method for enhancing permeability of topical drugs.
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  4. Drust Eugene G. (Norwich NY) Kasting Gerald B. (Wyoming OH) Smith Ronald L. (West Chester OH) Szkutak Joan B. (West Chester OH), Compositions for the transdermal delivery of pharmaceutical actives.
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  5. Henley Ernest J. (Houston TX), Crosslinked hydrogel and method for making same.
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  6. Phipps Joseph B. (Plymouth MN) Howland Warren W. (Champlin MN) Jevne Allan H. (Anoka MN) Holmblad Carolann (Cambridge MN), Device and method for iontophoretic drug delivery.
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  7. Sage, Jr., Burton H.; Bock, Carl R., Device and method for renewing electrodes during iontophoresis.
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  8. Sibalis Dan (268 Hallock Rd. Stony Brook NY 11790) Rosen Sanford (64 E. 86th St. New York NY 10028), Electrolytic transdermal delivery of proteins.
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  9. Gyory J. Richard (San Jose CA), Electrotransport agent delivery device and method.
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  10. Haak Ronald P. (Cupertino CA) Theeuwes Felix (Los Altos CA) Gyory J. Richard (Los Altos CA), Electrotransport transdermal system.
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  11. Lawter James R. (Goshen NY) Pawelchak John M. (Park Ridge NJ), Enchancers for the transdermal flux of nilvapidine.
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  12. Kamiya Tetsuro (Utsunomiya JPX) Tsuchiya Shuichi (Utsunomiya JPX) Hara Kenji (Utsunomiya JPX), External medication for skin.
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  13. Jevne Allan H. (Anoka MN) Vegoe Brett R. (Brooklyn Park MN) Holmblad Carolann M. (Cambridge MN) Cahalan Patrick T. (Champlin MN), Hydrophilic pressure sensitive biomedical adhesive composition.
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  14. Atanasoska Ljiljana, Iontophoresis electrode.
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  15. Untereker Darrel F. (Cedar MN) Phipps Joseph B. (Plymouth MN) Cahalan Patrick T. (Champlin MN) Brennen Kenneth R. (Fridley MN), Iontophoresis electrode.
    상세보기
  16. Haak Ronald P. (San Jose CA) Gyory J. Richard (San Jose CA) Theeuwes Felix (Los Altos CA) Landrau Felix A. (San Jose CA) Roth Nathan (San Francisco CA) Myers Robert M. (Stanford CA), Iontophoretic delivery device and method of hydrating same.
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  17. Haak Ronald P. (San Jose CA) Gyory J. Richard (San Jose CA) Theeuwes Felix (Los Altos CA) Landrau Felix A. (San Jose CA) Roth Nathan (San Francisco CA) Myers Robert M. (Stanford CA), Iontophoretic delivery device and method of hydrating same.
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  18. Haak, Ronald P.; Gyory, J. Richard; Theeuwes, Felix; Landrau, Felix A.; Roth, Nathan; Myers, Robert M., Iontophoretic delivery device and method of hydrating same.
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  19. Sage ; Jr. Burton H. (Raleigh NC) Flower Ronald J. (Vernon NJ), Iontophoretic drug delivery system and method for using same.
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  20. McArthur William Allan ; Stropkay Scott Edward ; Tanner Marc Walter,GBX, Iontophoretic drug delivery system, including removable controller.
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  21. Axelgaard Jens (811 Tumbleweed La. Fallbrook CA 92028), Medical electrode system.
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  22. Sanderson John E. (North Miami FL) Deriel Stanton R. (Pembroke Pines FL), Method and apparatus for iontophoretic drug delivery.
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  23. Sage ; Jr. Burton H. (Raleigh NC) Riviere Jim E. (Raleigh NC), Method and composition for iontophoresis.
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  24. Saito Kenichiro (Menlo Park CA) Heller Jorge (Woodside CA) Skinner Wilfred A. (Portla Valley CA), Method for percutaneously administering metoclopramide.
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  25. Saito Kenichiro (Menlo Park CA) Heller Jorge (Menlo Park CA) Skinner Wilfred A. (Menlo Park CA), Method for percutaneously administering physiologically active agents using an adjuvant a solvent and a diol moderator.
    상세보기
  26. Joyce, Patrick J., Method of administration of chemotherapy to tumors.
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  27. Sasaki Takao (Hachioji JPX) Otsuki Toshiaki (Yamanashi JPX) Eguchi Ryouji (Yamanashi JPX), Method of screwing a pipe to an object.
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  28. Petelenz Tomasz J. (Salt Lake City UT) Stephen Robert L. (Salt Lake City UT) Jacobsen Stephen C. (Salt Lake City UT), Methods and apparatus for iontophoresis application of medicaments.
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  29. Kigasawa Kazuo (Tokyo JPX) Ohtani Hideaki (Tokyo JPX) Tanaka Makoto (Tokyo JPX) Hayashida Shigeru (Tokyo JPX), Ointment base.
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  30. Konno Yutaka (Saitama JPX) Kawata Hiroitsu (Saitama JPX) Aruga Masayoshi (Saitama JPX) Sonobe Takashi (Saitama JPX) Mitomi Mitsuo (Tokyo JPX), Patch.
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  32. Yamada Masayuki (Hyogo JPX) Uda Yoshiaki (Hyogo JPX), Percutaneous pharmaceuticals preparation for external use.
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  33. Ueda Yoshio (Kobe JPX) Hata Takehisa (Muko JPX) Ibuki Rinta (Ashiya JPX) Kado Kazutake (Toyonaka JPX) Ishikuro Hiroshi (Ikeda JPX), Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter.
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  34. Eckert Theodor (Muenster DEX) Kemper Fritz H. (Muenster DEX) Wischniewski Martin (Neustadt a. Rbge. DEX) Hempel Reinhard (Hanover DEX), Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparati.
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  35. Llyod Lindsay B. (West Jordan UT) Beck Jon E. (Salt Lake City UT) Petelenz Tomasz J. (Salt Lake City UT), Rehydratable product and method of preparation thereof.
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  36. Chang Yunik (Lakewood NJ) Patel Dinesh C. (Murray UT), Skin penetration enhancement using free base and acid addition salt combinations of active agents.
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  37. Chiang Chia-Ming (Foster City CA) Cleary Gary W. (San Mateo CA), Skin permeation enhancer compositions, and methods and transdermal systems associated therewith.
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  38. Chiang Chia-Ming (Foster City CA) Cleary Gary W. (San Mateo CA), Skin permeation enhancer compositions, and methods and transdermal systems associated therewith.
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  39. Francoeur Michael L. (Stonington CT) Potts Russell O. (Old Saybrook CT), Topical compositions of lipophilic pharmaceuticals agents.
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  40. Gruber, Klaus; Lohner, Manfred; Posselt, Klaus; Wagener, Hans H., Transdermal 2-(4-isobutylphenyl)-propionic acid medication and methods.
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  41. Sharma Kuldeepak (Mountain View CA) Roy Samir D. (Mountain View CA) Roos Eric J. (Redwood City CA), Transdermal administration of buprenorphine.
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  42. Haak Ronald P. (Menlo Park CA) Theeuwes Felix (Los Altos Hills CA) Gyory J. Richard (San Jose CA) Lattin Gary A. (Forest Lake MN), Transdermal delivery device.
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  43. Haak Ronald P. (San Jose) Theeuwes Felix (Los Altos) Gyory J. Richard (San Jose CA), Transdermal delivery device.
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  44. Chien Yie W. (North Brunswick NJ) Corbo Michael (Piscataway NJ), Transdermal dosage unit, system and process.
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  45. Francoeur Michael L. (East Lyme CT) Potts Russell O. (Old Saybrook CT), Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals.
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  46. Konno Yutaka (Saitama JPX) Kawata Hiroitsu (Saitama JPX) Aruga Masayoshi (Saitama JPX) Sonobe Takashi (Saitama JPX) Mitomi Mitsuo (Tokyo JPX), Transdermal formulation of nicardipine hydrochloride.
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  47. Guse Gnter (Hamburg DEX) Horstmann Michael (Neuwied DEX) Erler Axel (Hamburg DEX), Transdermal therapeutic system.
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  48. Johnson Michael T. V. (Minneapolis MN) Lee Nina H. (Richfield MN), pH buffered electrode for medical iontophoresis.
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이 특허를 인용한 특허 (44)

  1. Yanaki, Jamal S., Active electrode for transdermal medicament administration.
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  2. Yanaki, Jamal S., Active transdermal medicament patch and circuit board for same.
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  3. Singh, Parminder; Cleary, Gary W.; Kulichikhin, Valery G.; Antonov, Sergey, Adhesive composition.
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  4. Martin,Paul J., Adhesive ion-conducting layer for flexible electrochromic devices.
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  5. Tokudome,Yoshihiro; Owaku,Koji; Goto,Kenichi; Sugibayashi,Kenji, Compositions for drug administration by electroporation.
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  6. Tokudome,Yoshihiro; Owaku,Koji; Goto,Kenichi; Sugibayashi,Kenji, Compositions for electroporation.
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  7. Hsu, Tsung-Min; Jacobson, Eric C.; LoBello, Rose C.; Luo, Eric C., Dual enhancer composition for topical and transdermal drug delivery.
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  8. Hsu, Tsung-Min; Jacobson, Eric C.; LoBello, Rose C.; Luo, Eric C., Dual enhancer composition for topical and transdermal drug delivery.
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  9. Keusch, Preston; Jain, Uday K.; Reddy, Vilambi Nrk; Eliash, Bruce M.; Carey, Kevin John; Falevich, Vitaly, Electrodes and method for manufacturing electrodes for electrically assisted drug delivery.
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  10. Cleary, Gary W.; Parandoosh, Shoreh; Feldstein, Mikhail M.; Chalykh, Anatoly E.; Platé, Nicolai A.; Kulichikhin, Valery G., Hydrogel Compositions.
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  11. Cleary, Gary W.; Parandoosh, Shoreh; Feldstein, Mikhail M.; Chalykh, Anatoly E.; Platé, Nicolai A.; Kulichikhin, Valery G., Hydrogel compositions.
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  12. Singh, Parminder; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir R., Hydrogel compositions demonstrating phase separation on contact with aqueous media.
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  13. Singh, Parminder; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir R., Hydrogel compositions demonstrating phase separation on contact with aqueous media.
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  14. Singh, Parminder; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir R., Hydrogel compositions for tooth whitening.
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  15. Singh, Parminder; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bayramov, Danir F., Hydrogel compositions for tooth whitening.
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  16. Singh, Parminder; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bayramov, Danir F., Hydrogel compositions for tooth whitening.
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  17. Singh, Parminder; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bayramov, Danir F., Hydrogel compositions for tooth whitening.
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  18. Singh, Parminder; Faasse, Adrian; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir F., Hydrogel compositions with an erodible backing member.
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  19. Singh, Parminder; Faasse, Adrian; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir F., Hydrogel compositions with an erodible backing member.
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  20. Singh, Parminder; Faasse, Adrian; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir R., Hydrogel compositions with an erodible backing member.
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  21. Singh, Parminder; Faasse, Adrian; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bayramov, Danir F., Hydrogel compositions with an erodible backing member.
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  22. Luo, Eric C.; Jacobson, Eric C.; Hsu, Tsung-Min, Hydroxide-releasing agents as skin permeation enhancers.
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  23. Carter, Darrick, Iontophoretic device and method of delivery of active agents to biological interface.
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  24. Carter, Darrick; Smith, Gregory A., Iontophoretic systems, devices, and methods of delivery of active agents to biological interface.
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  25. Miller,David J.; Higuchi,William I.; Li,Kevin; Flynn,Gordon L., Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent.
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  26. Feldstein, Mikhail M.; Bairamov, Danir F.; Platé, Nicolai A.; Kulichikhin, Valery G.; Chalykh, Anatoly E.; Cleary, Gary W.; Singh, Parminder, Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components.
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  27. Cleary, Gary W.; Parandoosh, Shoreh; Feldstein, Mikhail M.; Chalykh, Anatoly E.; Platè, Nicolai A.; Kulichikhin, Valery G., Non-electrically conductive hydrogel composition.
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  28. Tokudome, Yoshihiro; Owaku, Koji; Goto, Kenichi; Sugibayashi, Kenji, Percutaneous absorption promoters for electroporation.
    상세보기
  29. Feldstein, Mikhail M.; Platè, Nicolai A.; Chalykh, Anatoly E.; Cleary, Gary W., Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties.
    상세보기
  30. Feldstein, Mikhail M.; Platè, Nicolai A.; Chalykh, Anatoly E.; Cleary, Gary W., Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties.
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  31. Singh, Parminder; Mudumba, Sri; Bairamov, Danir R.; Kulichikhin, Valery G.; Feldstein, Mikhail M.; Cleary, Gary W., Rapidly dissolving film for delivery of an active agent.
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  32. Singh, Parminder; Mudumba, Sri; Bayramov, Danir F.; Kulichikhin, Valery G.; Feldstein, Mikhail M.; Cleary, Gary W., Rapidly dissolving film for delivery of an active agent.
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  33. Jain, Uday K.; Reddy, Vilambi N R K; Eliash, Bruce M.; Carey, Kevin John; Falevich, Vitaly; Keusch, Preston, Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode.
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  34. Luo, Eric C.; Hsu, Tsung-Min, Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers.
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  35. Luo, Eric C.; Jacobson, Eric C.; Hsu, Tsung-Min, Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers.
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  36. Hsu, Tsung-Min; Macy, Russell; Luo, Eric C., Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers.
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  37. Singh, Parminder; Lee, Eun Soo; Jain, Amit K., Transdermal administration of tamsulosin.
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  38. Singh, Parminder; Lee, Eun Soo; Jain, Amit K., Transdermal administration of tamsulosin.
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  39. Singh, Parminder; Lee, Eun Soo; Jain, Amit K., Transdermal administration of tamsulosin.
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  40. Luo, Eric C.; Gricenko, Nicole T.; Hsu, Tsung-Min, Transdermal and topical administration of local anesthetic agents using basic enhancers.
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  41. Cleary, Gary W.; Feldstein, Mikhail M.; Kulichikhin, Valery G.; Bairamov, Danir F., Two-phase, water-absorbent bioadhesive composition.
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  42. Feldstein, Mikhail M.; Bairamov, Danir F.; Novikov, Mikhail Borisovich; Kulichikhin, Valery G.; Platé, Nicolai A.; Cleary, Gary W.; Singh, Parminder, Water-absorbent adhesive compositions and associated methods of manufacture and use.
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  43. Feldstein, Mikhail M.; Bairamov, Danir F.; Novikov, Mikhail Borisovich; Kulichikhin, Valery G.; Platé, Nicolai A.; Cleary, Gary W.; Singh, Parminder, Water-absorbent adhesive compositions and associated methods of manufacture and use.
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  44. Feldstein, Mikhail M.; Bayramov, Danir F.; Novikov, Mikhail Borisovich; Kulichikhin, Valery G.; Platè, Nicolai A.; Cleary, Gary W.; Singh, Parminder, Water-absorbent adhesive compositions and associated methods of manufacture and use.
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