초록 ▼

Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to fo

Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.

대표청구항 ▼

[ That which is claimed is:] [1.] A pharmaceutical formulation comprising fixed-dried blood platelets, said fixed-dried blood platelets consisting essentially of human blood platelets which, upon reconstitution in an aqueous pharmaceutically acceptable carrier:adhere to thrombogenic surfaces;do not

[ That which is claimed is:] [1.] A pharmaceutical formulation comprising fixed-dried blood platelets, said fixed-dried blood platelets consisting essentially of human blood platelets which, upon reconstitution in an aqueous pharmaceutically acceptable carrier:adhere to thrombogenic surfaces;do not adhere to non-thrombogenic surfaces;undergo shape change upon adhering to a thrombogenic surface;adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; andrelease their granular contents.