초록 ▼

A medical device is coated with a thin coherent bond coat of acrylics, epoxies, acetals, ethylene copolymers, vinyl polymers, polymers containing hydroxyl, amine, carboxyl, amide, or other reactive groups, and copolymers thereof. Outer layers may be applied and remain adherent to the substrate in wa

A medical device is coated with a thin coherent bond coat of acrylics, epoxies, acetals, ethylene copolymers, vinyl polymers, polymers containing hydroxyl, amine, carboxyl, amide, or other reactive groups, and copolymers thereof. Outer layers may be applied and remain adherent to the substrate in water for an extended period. The bond coat may comprise cross linkers such as urea resins, melamines, isocyanates, and phenolics. Preferred polymers include vinylpyrrolidone-vinyl acetate, styrene acrylic polymer, ethylene acrylic acid copolymer, carboxyl function acrylic polymer, hydroxyl function acrylic polymer, and acrylic dispersion polymer. The coatings may be applied to inert metal or plastic surfaces of medical devices such as needles, guide wires, catheters, surgical instruments, equipment for endoscopy, wires, stents, angioplasty balloons, wound drains, arteriovenous shunts, gastroenteric tubes, urethral inserts, laparoscopic equipment, pellets, and implants. Methods of coating and coating liquids are provided.

대표청구항 ▼

[ What is claimed is:] [1.] An insertable medical device comprising an inert surface of the device that does not have reactive functional groups, the inert surface being modified by a biocompatible surface coating, the surface coating comprising:(a) a coherent bond coat layer applied to the inert su

[ What is claimed is:] [1.] An insertable medical device comprising an inert surface of the device that does not have reactive functional groups, the inert surface being modified by a biocompatible surface coating, the surface coating comprising:(a) a coherent bond coat layer applied to the inert surface with a thickness below about 100 microns such that the bond coat layerdoes not penetrate into the device, the bond coat layer comprising at least one bonding polymer bonded with non-covalent bonds with the inert surface of the device, wherein the bond coat layer comprises a cross-linked matrix, and further comprising(b) an outer layer applied to the bond coat layer that adheres to the bond coat layer, the coating remaining adherent to the surface and resistant to abrasion and to removal from the device after soaking in water relative to a coating without the bond coat layer.