초록 ▼

An implant having an integrally-textured, hemocompatible blood-contacting surface and a method for producing the same is provided. The implantable device can include a device body having a textured surface and a predefined complex shape, such as a bladder or a generally U-shaped conduit. The device

An implant having an integrally-textured, hemocompatible blood-contacting surface and a method for producing the same is provided. The implantable device can include a device body having a textured surface and a predefined complex shape, such as a bladder or a generally U-shaped conduit. The device body can be composed of a first device material, and the textured surface can be formed of a second device material on the obverse side of the device. The textured surface can have multiple, blood-compatible structures integrally formed thereon. The structures can be fibrils that are suitable for a generally uniform biological layer to be established thereupon. The method for producing an implantable device can include the steps of fabricating a mold; applying a flock to the mold; introducing a conformable dissoluble material to the mold; removing the dissoluble material from the mold; removing the flock from the dissoluble material using a first solvent thereby creating a dissoluble device form having a form surface having multiple invaginations therein; applying a layer of a selected device material to the dissoluble device form thereby providing a device wall with the structures being integrally formed thereon; and removing the dissoluble device form from the device wall by liquefying the device form, thereby providing the implantable device.

대표청구항 ▼

[ I claim:] [1.] A method for producing an implantable device having an internal, closed blood-contacting surface and a complex shape, said complex shape being asymmetric, comprising the steps of:a. fabricating a mold having a complex shape corresponding to at least a portion of said implantable dev

[ I claim:] [1.] A method for producing an implantable device having an internal, closed blood-contacting surface and a complex shape, said complex shape being asymmetric, comprising the steps of:a. fabricating a mold having a complex shape corresponding to at least a portion of said implantable device;b. applying a flock to said mold;c. introducing a conformable dissoluble material to said mold, said flock being at least partially embedded in a dissoluble material surface of said dissoluble material adjacent to said mold;d. removing said dissoluble material having said embedded flock therein from said mold;e. removing said flock from said dissoluble material using a first solvent thereby creating a dissoluble device form having a form surface, said form surface corresponding to said dissoluble material surface and having a plurality of invaginations therein, said flock being substantially soluble in said first solvent and said dissoluble device form being substantially insoluble in said first solvent;f. applying a layer of a selected biologically stable device material to said dissoluble device form thereby forming a device wall thereon, said device material penetrating said plurality of invaginations of said form surface thereby forming a plurality of structures within respective ones of said plurality of invaginations, said device wall having said structures integrally formed thereon; andg. removing said dissoluble device form from said device wall and said structures thereon by liquefying said dissoluble device form thereby providing said implantable device.