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Transdermal protein delivery using low-frequency sonophoresis 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61B-017/00
출원번호 US-0507060 (1995-07-25)
발명자 / 주소
  • Mitragotri Samir S.
  • Blankschtein Daniel
  • Langer Robert S.
출원인 / 주소
  • Massachusetts Institute of Technology
대리인 / 주소
    Arnall Golden & Gregory, LLP
인용정보 피인용 횟수 : 209  인용 특허 : 43

초록 ▼

Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in

대표청구항 ▼

[ We claim:] [1.] A method for enhancing delivery of a drug in a single step across the skin into the blood using ultrasound wherein the ultrasound is applied by pulsing at a frequency of between 20 kHz and less than 1 MHz at an intensity not causing any irreversible skin damage for a period of time

이 특허에 인용된 특허 (43)

  1. Yamada Yoshihisa (Kyoto JPX) Matsuoka Yuzo (Toyonaka JPX), 6-Halo-1,2,3,4-tetrahydroquinazoline-4-spiro-4-imidazolidine-2,2′5′-triones useful for the treatment and prophylaxis o.
    상세보기
  2. Stanley Theodore H. (Salt Lake City UT) Ebert Charles D. (Salt Lake City UT) Higuchi William I. (Salt Lake City UT) Zhang Jie (Salt Lake City UT), Apparatus and method for noninvasive blood glucose monitoring.
    상세보기
  3. Heller Jorge (Palo Alto CA) Baker Richard W. (Bend OR), Bioerodible system for delivering drug manufactured from poly(carboxylic acid).
    상세보기
  4. Tachibana Shunro (Fukuoka JPX) Sogawa Ichiro (Osaka JPX) Tachibana Katsuro (Fukuoka JPX), Blood processing for treating blood disease.
    상세보기
  5. Tachibana Katsuro (6-18 ; Kusagae 1-chome ; Chuo-ku Fukuoka-shi ; Fukuoka 810 JPX) Tachibana Shunro (6-18 ; Kusagae 1-chome ; Chuo-ku Fukuoka-shi ; Fukuoka 810 JPX), Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same.
    상세보기
  6. Takemoto ; Kiyochika ; Suzuki ; Yasuo ; Ochiai ; Yoshihito ; Nakashima ; Syozi ; Hayashi ; Midori, Devices for transmitting ultrasonic waves to teeth.
    상세보기
  7. Fox Martin D. (Storrs CT), Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a.
    상세보기
  8. Shimada Jin (Falcon Heights MN) Shapland James E. (Shoreview ; both MN), Drug delivery by multiple frequency phonophoresis.
    상세보기
  9. D\Angelo Joseph P. (Miami FL) Schur Henry (Miami FL), Electronic transdermal drug delivery system.
    상세보기
  10. Tachibana Shunro (1-6-18 ; Kusagae Chuo-ku ; Fukuoka-shi ; Fukuoka-ken JPX) Shibata Uichi (Tokyo JPX), Endermic application kits for external medicines.
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  11. Tachibana Shunro (1-6-18 Kusagae ; Chuo-ku ; Fukuoka-shi ; Fukuoka-ken JPX) Shibata Uichi (Tokyo JPX), Endermic application kits for external medicines.
    상세보기
  12. Tachibana Shunro (Fukuoka JPX) Shibata Uichi (Tokyo JPX), Endermic application kits for external medicines.
    상세보기
  13. Flanagan Dennis F. (1671 W. Main St. Willimantic CT 06226), Endermic method and apparatus.
    상세보기
  14. Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT), Enhancement of transdermal delivery with ultrasound and chemical enhancers.
    상세보기
  15. Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT) Kost Joseph (Omer MA ILX) Langer Robert S. (Newton MA), Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers.
    상세보기
  16. Kobayashi Atsushi (Nagano JPX) Suzuki Takashi (Nagano JPX) Kosugi Yasuhiko (Nagano JPX), Image forming apparatus.
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  17. Kalish Stanley (2727 De Anza Rd. ; M-22 San Diego CA 92109), Impregnated bandage.
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  18. Tachibana Shunro (6-18 ; Kusagae 1-chome Chuo-ku ; Fukuoka-shi ; Fukuoka-ken JPX), Injection instrument with ultrasonic oscillating element.
    상세보기
  19. Driller Jack (Ridgewood NJ) Faulkenberry William J. (Long Island City NY) Lizzi Frederic L. (Tenafly NJ), Local application of medication with ultrasound.
    상세보기
  20. Rosler, Richard S.; Engle, George M., Metal-silicide deposition using plasma-enhanced chemical vapor deposition.
    상세보기
  21. Schoendorfer Donald W. (Santa Ana CA) Miller William R. (Santa Ana CA), Method and apparatus for determination of chemical species in body fluid.
    상세보기
  22. Sterzer Fred (Lawrence Township ; Mercer County NJ), Method for enhancing delivery of chemotherapy employing high-frequency force fields.
    상세보기
  23. Moasser Manoutchehr (16005 Crain Hwy. Brandywine MD 20613), Method for treating herpes lesions and other infectious skin conditions.
    상세보기
  24. Nuwayser Elie S. (Wellesley MA), Method of transdermal drug delivery.
    상세보기
  25. Buchalter Gilbert (555 Mount Prospect Ave. Newark NJ 07104), Method of transmitting ultrasonic impulses to surface using transducer coupling agent.
    상세보기
  26. Schroeder Jon M. (14301 Bagdad Rd. Leander TX 78641) Long Joseph F. (1335 Lost Creek Rd. Austin TX 78746), Noninvasive blood glucose measuring device.
    상세보기
  27. Cooper, Eugene R., Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone.
    상세보기
  28. Patel Dinesh C. (Murray UT) Chang Yunik (Lakewood NJ), Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols.
    상세보기
  29. Henley Julian L. (330 Orchard St. New Haven CT 06511-4417), Programmable apparatus for the transdermal delivery of drugs and method.
    상세보기
  30. Cleary Gary W. (San Mateo CA) Roy Samir (Redwood City CA), Resilient transdermal drug delivery device.
    상세보기
  31. Korol Bernard (11908 Country Club Dr. St. Louis MO 63131), Synthetic resin wound dressing and method of treatment using same.
    상세보기
  32. Cosgrove ; Jr. Robert J. (5009 Juiata Dr. Birmingham AL 35210) Smolen Victor F. (227 Timbercrest Rd. West Lafayette IN 47905), System for automatic feedback-controlled administration of drugs.
    상세보기
  33. Fahim Mostafa S. (Columbia MO), Topical application of medication by ultrasound with coupling agent.
    상세보기
  34. Takemoto Kiyochika (Kodaira JPX) Suzuki Yasuo (Kurume JPX) Ochiai Yoshihito (Fujisawa JPX) Nakashima Syozi (Yamanishi JPX) Hayashi Midori (Yamakita JPX), Torsional ultrasonic vibrators.
    상세보기
  35. Sanders Harold F. (Palo Alto CA) Cheng Yu-Ling (Cupertino CA) Enscore David J. (Saratoga CA) Libicki Shari B. (Palo Alto CA), Transdermal drug composition with dual permeation enhancers.
    상세보기
  36. Fahim Mostafa S. (500 Hulen Dr. Columbia MO 65201), Treatment of acne and skin disorders and compositions therefor.
    상세보기
  37. Greenfeld Albert R. (31430 Glenbridge Rd. Westlake Village CA 91361) Reis Herbert (Thousand Oaks CA) Tittmann Bernhard R. (Thousand Oaks CA), Ultrasonic self-cleaning catheter system for indwelling drains and medication supply.
    상세보기
  38. Lipkovker Lev M. (Bellevue WA), Ultrasonic transdermal drug delivery system.
    상세보기
  39. Kost Joseph (Omer MA ILX) Langer Robert S. (Somerville MA), Ultrasound enchancement of membrane permeability.
    상세보기
  40. Kost Joseph (Omer ILX) Levy Drora (Herzlia MA ILX) Langer Robert S. (Somerville MA), Ultrasound enhancement of transdermal drug delivery.
    상세보기
  41. Bommannan Durairaj (San Francisco CA) Okuyama Hirohisa (San Francisco CA) Guy Richard H. (San Francisco CA) Stauffer Paul (San Rafael CA) Flynn Gordon L. (Ann Arbor MI), Ultrasound-enhanced delivery of materials into and through the skin.
    상세보기
  42. Bommannan Durairaj (San Francisco CA) Okuyama Hirohisa (San Francisco CA) Guy Richard H. (San Francisco CA) Stauffer Paul (San Rafael CA) Flynn Gordon L. (Ann Arbor MI), Ultrasound-enhanced delivery of materials into and through the skin.
    상세보기
  43. Bommannan Durairaj (San Francisco CA) Okuyama Hirohisa (San Francisco CA) Guy Richard H. (San Francisco CA) Stauffer Paul (San Rafael CA) Flynn Gordon L. (Ann Arbor MI), Ultrasound-enhanced delivery of materials into and through the skin.
    상세보기

이 특허를 인용한 특허 (209)

  1. Cole, Jean-Pierre; Fennell, Martin J., Analyte monitoring device and methods.
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  2. Drucker, Steven H.; Jin, Robert Y.; Funderburk, Jeffery V., Analyte monitoring device and methods of use.
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  3. Drucker, Steven H.; Jin, Robert Y.; Funderburk, Jeffery V., Analyte monitoring device and methods of use.
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  4. Heller, Adam; Drucker, Steven H.; Jin, Robert Y.; Funderburk, Jeffery V., Analyte monitoring device and methods of use.
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  5. Heller, Adam; Drucker, Steven H.; Jin, Robert Y.; Funderburk, Jeffery V., Analyte monitoring device and methods of use.
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  6. Heller, Adam; Drucker, Steven H.; Jin, Robert Y.; Funderburk, Jeffery V., Analyte monitoring device and methods of use.
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  7. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
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  8. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
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  9. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
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  10. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
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  11. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
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  12. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
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  13. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
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  14. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
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  15. Heller, Adam; Feldman, Benjamin Jay; Karinka, Shridhara Alva; Wang, Yi; Galasso, John R., Analyte monitoring device and methods of use.
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  16. Peyser, Thomas A.; Heller, Adam, Analyte monitoring device and methods of use.
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  17. Peyser, Thomas; Heller, Adam, Analyte monitoring device and methods of use.
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  18. Peyser, Thomas; Heller, Adam, Analyte monitoring device and methods of use.
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  19. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
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  20. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
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  21. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  22. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  23. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
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  24. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
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  25. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
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  26. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
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  27. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Colman, Fredric C., Analyte monitoring device and methods of use.
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  28. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
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  29. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
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  30. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
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  31. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  32. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  33. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  34. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  35. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  36. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  37. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  38. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  39. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  40. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  41. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  42. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  43. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  44. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  45. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  46. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  47. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  48. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  49. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  50. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  51. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  52. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  53. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  54. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  55. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  56. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  57. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  58. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
    상세보기
  59. Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
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