초록 ▼

An improved process for manufacturing transdermal drug delivery devices and devices made therefrom. The invention provides a heat equilibration process for the manufacture of drug delivery devices which eliminates the need to preload the body contacting layer with a drug. The method has particular a

An improved process for manufacturing transdermal drug delivery devices and devices made therefrom. The invention provides a heat equilibration process for the manufacture of drug delivery devices which eliminates the need to preload the body contacting layer with a drug. The method has particular application in the manufacture of transdermal drug delivery devices including a drug reservoir comprising drug in excess of saturation.

대표청구항 ▼

[ What is claimed is:] [1.] A method for manufacturing a drug delivery device having more than one layer containing a concentration of drug in excess of saturation which method comprises:forming a device comprising a first layer initially containing drug in excess of saturation and a second layer in

[ What is claimed is:] [1.] A method for manufacturing a drug delivery device having more than one layer containing a concentration of drug in excess of saturation which method comprises:forming a device comprising a first layer initially containing drug in excess of saturation and a second layer initially free of drug;subjecting the device to an elevated temperature for a predetermined period of time sufficient to cause a predetermined amount of a drug to migrate from said first layer into said second layer; andrapidly cooling the device to ambient conditions, wherein said first and second layers contain an amount of drug in excess of saturation after said cooling step.