초록 ▼

Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer and a monolithic carrier layer formed from a melt blend of an active ingredient with a thermoplastic matrix polymer without first dissolving or suspendi

Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer and a monolithic carrier layer formed from a melt blend of an active ingredient with a thermoplastic matrix polymer without first dissolving or suspending the polymer or active ingredient in a solvent therefor, so that the carrier layer is substantially free of residual solvent, wherein the thermoplastic matrix polymer has a melt temperature between about 170.degree. C. and about 200.degree. C. and is selected from polyether block amides, ethylene methacrylic acid copolymers, ethylene acrylic acid copolymers, copolymers of polyether prepolymers with polybutylene terephthalate, copolymers of polyether prepolymers with polyisobutylene terephthalate and polyether polyurethanes, the active ingredient is heat stable at the melt temperature of the matrix polymer and is selected from active agents, active agent enhancers and mixtures thereof, and the laminate is provided with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed.

대표청구항 ▼

[ What is claimed is:] [1.] A device for the controlled release of an active agent to the skin or mucosa of a host, said device comprising a laminate of:(a) a monolithic carrier layer having a first surface and a second surface, said monolithic carrier layer comprising an active ingredient melt-blen

[ What is claimed is:] [1.] A device for the controlled release of an active agent to the skin or mucosa of a host, said device comprising a laminate of:(a) a monolithic carrier layer having a first surface and a second surface, said monolithic carrier layer comprising an active ingredient melt-blended with a thermoplastic matrix polymer and formed into said carrier layer without first dissolving or suspending said polymer or active ingredient in a solvent therefor, so that said carrier layer is substantially free of residual solvent, wherein said thermoplastic matrix polymer has a melt temperature between about 170.degree. C. and about 200.degree. C. and is selected from the group consisting of polyether block amides, ethylene methacrylic acid copolymers, ethylene acrylic acid copolymers, copolymers of polyether prepolymers with polybutylene terephthalate, copolymers of polyether prepolymers with polyisobutylene terephthalate and polyether polyurethanes, said polymer is capable of controllably releasing said active ingredient, and said active ingredient is heat stable at the melt temperature of said matrix polymer, and is selected from the group consisting of active agents, active agent enhancers, and mixtures thereof;(b) a backing layer having an inner surface and an outer surface, wherein said second surface of said carrier layer and said inner surface of said backing layer are laminated together with an adhesive, so that said active ingredient cannot permeate from said second surface of said carrier layer through said outer surface of said backing layer; and(c) a pressure-sensitive adhesive layer for affixing said laminate to said skin or mucosa of said host so that said active ingredient is capable of being continuously released from said first surface of said carrier layer thereto.