초록 ▼

Biodegradable, porous, polymeric implant material provides substantially continuous release of bioactive agent during in vivo use. Bioactive agent is initially released in amounts that are less than degradation rate of polymer, thereby promoting migration of cells into material. Later larger amounts

Biodegradable, porous, polymeric implant material provides substantially continuous release of bioactive agent during in vivo use. Bioactive agent is initially released in amounts that are less than degradation rate of polymer, thereby promoting migration of cells into material. Later larger amounts of bioactive agent is released, thereby promoting differentiation of cells. Method of making material includes step of applying vacuum to form pores. Implant material may be adapted for one phase implant (e.g., for bone or cartilage) or for two phase layered implant (e.g., for cartilage layer on top of bone layer).

대표청구항 ▼

[ We claim:] [1.] An implant material comprising a biodegradable, porous and polymeric material having a pore size between about 50 .mu.m and about 200 .mu.m, and at least about 50% by volume porosity, the implant material comprising a bioactive agent substantially uniformly incorporated therein suc

[ We claim:] [1.] An implant material comprising a biodegradable, porous and polymeric material having a pore size between about 50 .mu.m and about 200 .mu.m, and at least about 50% by volume porosity, the implant material comprising a bioactive agent substantially uniformly incorporated therein such that, when the implant material is used in an in vivo environment, the implant material provides a substantially smooth continuous release of the bioactive agent during the first two weeks of use.