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Preparation of diagnostic agents 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-049/00
  • A61B-008/00
  • A61B-008/02
출원번호 US-0517590 (1995-08-22)
우선권정보 GB-0007628 (1991-04-10)
발명자 / 주소
  • Sutton Andrew D.,GBX
  • Johnson Richard A.,GBX
  • Senior Peter J.,GBX
  • Heath David,GBX
출원인 / 주소
  • Quadrant Healthcare (UK) Limited, GBX
대리인 / 주소
    Sterne, Kessler, Goldstein and Fox P.L.L.C.
인용정보 피인용 횟수 : 25  인용 특허 : 32

초록

The microcapsules have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced.

대표청구항

[ We claim:] [1.] Sterile hollow microcapsules with proteinaceous walls in which at least 90% of the microcapsules have a diameter in the range 1.0-8.0 .mu.m; at least 90% of the microcapsules have a wall thickness of 40-500 nm; and at least 50% of the protein in the walls of the microcapsules is so

이 특허에 인용된 특허 (32)

  1. Hilmann Juergen (Berlin DEX) Hoffmann Rolf-Ruediger (Berlin DEX) Muetzel Wolfgang (Berlin DEX) Zimmermann Ingfried (Berlin DEX), Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium.
  2. Widder Kenneth J. (Del Mar CA) Westkaemper Peter J. (San Diego CA), Concentrated stabilized microbubble-type ultrasonic imaging agent.
  3. Cerny David (Chula Vista CA) Mills Gary J. (San Diego CA) Westkaemper Peter J. (San Diego CA), Continuous sonication method for preparing protein encapsulated microbubbles.
  4. Klaveness Jo (Oslo NOX) Rongved Pal (Hellvik NOX) Solberg Jan (Eiksmarka NOX) Strande Per (Oslo NOX) Wiggen Unni Nordby (Rasta NOX) Redford Keith (Hagan NOX), Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons.
  5. Yudelson Joseph S. (Rochester) Power Susan E. (Rochester NY), Contrast agents for ultrasound imaging.
  6. Rssling Georg (Berlin DEX) Albayrak Celal (Berlin DEX) Rothe Matthias (Berlin DEX) Siegert Joachim (Berlin DEX), Contrast media synthesized from polyaldehydes.
  7. Tickner Ernest G. (Gilroy CA), Flow rate measurement.
  8. Delgado Joaquin (St. Paul MN), Hollow acid-free acrylate polymeric microspheres having multiple small voids.
  9. Oppenheim ; Richard Charles ; Marty ; Jennifer Joy ; Speiser ; Peter, Injectable compositions, nanoparticles useful therein, and process of manufacturing same.
  10. Ryan Patrick J. (Worcester MA) Davis Michael A. (Westwood MA) Melchior Donald L. (Framingham MA), Lipisomes containing gas for ultrasound detection.
  11. Unger Evan C. (Tucson AZ), Low density microspheres and their use as contrast agents for computed tomography, and in other applications.
  12. Sands Bruce W. (Malvern PA), Manufacturing process for hollow microspheres.
  13. Yen Richard C. K. (4261 Chase Ave. Los Angeles CA 90066), Manufacturing protein microspheres.
  14. Mathiowitz Edith (Brookline MA) Bernstein Howard (Cambridge MA) Morrel Eric (Needham MA) Schwaller Kirsten (Duxbury MA), Method for producing protein microspheres.
  15. D\Arrigo Joseph S. (Farmington CT), Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and the.
  16. Temple ; Rodger G., Method of preparing microcapsules.
  17. Netting David I. (Springfield PA) Hertzenberg Elliot P. (Wilmington DE), Method of preparing modified hollow, largely spherical particles by spray drying.
  18. Kondo ; Sadao ; Nakano ; Hidehiko, Method of producing microcapsules and resulting product.
  19. Rasor Julia S. (Cupertino CA) Tickner Ernest G. (Gilroy CA), Microbubble precursors and methods for their production and use.
  20. Rhim Won-Kyu (Pasadena CA) Hyson Michael T. (Glendale CA) Chung Sang-Kun (Diamond Bar CA) Colvin Michael S. (Malibu CA) Chang Manchium (Los Angeles CA), Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops.
  21. Vassiliades Anthony E. (Deerfield IL) Shroff Shrenik (Lake Forest IL) Nauman Edward F. (Chicago IL), Oil-in-water emulsions containing hydropholeic starch.
  22. Timonen Maritta (Helsinki FIX) Rha Chokyun (Boston MA), Polymeric capsules, method of making the same, and foodstuffs containing the same.
  23. Sutton Andrew D. (Ruddington GB2) Johnson Richard A. (West Bridgford GB2) Senior Peter J. (Near Melbourne GB2) Heath David (The Park GB2), Preparation of diagnostic agents.
  24. Watanabe ; Sumio ; Mizuno ; Yasuhiko ; Kayano ; Masanori ; Ishino ; Yosh io, Process for the preparation of hollow particulates.
  25. Kendall ; Jr. James M. (Pasadena CA) Wang Taylor G. (Glendale CA) Elleman Daniel D. (San Marino CA), Shell forming system.
  26. Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
  27. Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
  28. Erbel Raimund (Mainz DEX) Zotz Rainer (Mainz DEX) Krone Volker (Flrsheim DEX) Magerstdt Michael (Hofheim am Taunus DEX) Walch Axel (Frankfurt am Main DEX), Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents.
  29. Erbel Raimund (Mainz DEX) Zotz Rainer (Mainz DEX) Krone Volker (Flrsheim DEX) Magerstdt Michael (Hofheim am Taunus DEX) Walch Axel (Frankfurt am Main DEX), Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents.
  30. Erbel Raimund (Mainz) Zotz Rainer (Mainz) Krone Volker (Flrsheim) Magerstdt Michael (Hofheim am Tanus) Walch Axel (Frankfurt am Main DEX), Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents.
  31. Tickner Ernest G. (Morgan Hill CA) Rasor Ned S. (Santa Clara County CA), Ultrasonic image enhancement.
  32. Feinstein Steven B. (295 Hasting Ave. Highland Park IL 60035), Ultrasonic imaging agent and method of preparation.

이 특허를 인용한 특허 (25)

  1. Platz, Robert M.; Brewer, Thomas K.; Boardman, Terence D., Dispersible macromolecule compositions and methods for their preparation and use.
  2. Whitfield, Nicola; Koopman, Jaap; Grimbergen, Jos, Dry powder fibrin sealant.
  3. Johnson Richard Alan,GBX ; Van Der Wouw Paulus Antonius,NLX, Hollow microcapsules for methods of ultrasound imaging.
  4. Chickering, III, Donald E.; Narasimhan, Sridhar; Altreuter, David; Kopesky, Paul; Keegan, Mark; Straub, Julie A.; Bernstein, Howard, Methods and apparatus for making particles using spray dryer and in-line jet mill.
  5. Chickering, III, Donald E.; Narasimhan, Sridhar; Altreuter, David; Kopesky, Paul; Keegan, Mark; Straub, Julie A.; Bernstein, Howard, Methods and apparatus for making particles using spray dryer and in-line jet mill.
  6. Chickering, III, Donald E.; Narasimhan, Sridhar; Altreuter, David; Kopesky, Paul; Keegan, Mark; Straub, Julie A.; Bernstein, Howard, Methods and apparatus for making particles using spray dryer and in-line jet mill.
  7. Stillman,Suzanne Jaffe, Nutritionally fortified liquid composition with added value delivery systems/elements/additives.
  8. York, Peter; Shekunov, Boris Yu; Rehman, Mahboob Ur; Feeley, Jane Catherine, Particulate materials.
  9. York, Peter; Shekunov, Boris Yu; Rehman, Mahboob Ur; Feeley, Jane Catherine, Particulate materials.
  10. York, Peter; Shekunov, Boris Yu; Rehman, Mahboob Ur; Feeley, Jane Catherine, Particulate materials.
  11. Wang, Zhaolin; Finlay, Warren H., Powder formation by atmospheric spray-freeze drying.
  12. Snyder, Herman E.; Nasiatka, James; Varga, Christopher M., Prefilming atomizer.
  13. Snyder, Herman E; Nasiatka, James; Varga, Christopher M, Prefilming atomizer.
  14. Sutton, Andrew D.; Johnson, Richard A.; Senior, Peter J.; Heath, David, Preparation of diagnostic agents.
  15. Sutton, Andrew Derek; Johnson, Richard Alan, Preparation of further diagnostic agents.
  16. Snyder, Herman E.; Vosberg, Michael J.; Varga, Christopher M., Spray drying methods and related compositions.
  17. Snyder, Herman E; Vosberg, Michael J; Varga, Christopher M, Spray drying methods and related compositions.
  18. Bennett, David B.; Brewer, Thomas K.; Platz, Robert M.; Snyder, Herman, Spray drying process control of drying kinetics.
  19. Bennett, David B; Brewer, Thomas K; Platz, Robert M; Snyder, Herman, Spray drying process control of drying kinetics.
  20. Sutton, Andrew D.; Johnson, Richard A.; Senior, Peter J.; Heath, David, Spray-dried microparticles and their use as therapeutic vehicles.
  21. Gordon, Marc S.; Clark, Andrew; Brewer, Thomas K., Systems and processes for spray drying hydrophobic and hydrophilic components.
  22. Stillman, Suzanne Jaffe, Water containing soluble fiber.
  23. Stillman, Suzanne Jaffe, Water containing soluble fiber.
  24. Stillman, Suzanne Jaffe, Water containing soluble fiber.
  25. Stillman, Suzanne Jaffe, Water containing soluble fiber.
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