초록 ▼

A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more s

A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more sampling chambers that functions alternatively as both an anode and cathode during the course of the method; reversing the polarity to cause direct current to flow in second direction opposite the first direction; and analyzing the sampling chamber or chambers for the concentration of a substance or a substance metabolite. There is also provided a device for sampling of a substance from an organism on continuously or intermittently using alternating polarity method based on the application of low intensity electric fields of alternating polarity across the skin (iontophoresis) to enhance the transport of a substance (such as glucose, lactic acid, pyruvic acid, and the like) from body tissues to a sampling chamber. The device comprises an electrical power supply; a transdermal system that contains one or more sampling chambers that function as both anode and cathode during the course of sampling; a means to alternates or reverses the polarity during the iontophoretic sampling; and means for analyzing for the concentration of a substance or a substance metabolite.

대표청구항 ▼

[ What is claimed is:] [1.] A non-invasive method for sampling a substance from a subject comprising:(a) placing a first sampling chamber and electrode in electrical communication with a first tissue surface of the subject;(b) conducting electrical current through the first tissue surface in a first

[ What is claimed is:] [1.] A non-invasive method for sampling a substance from a subject comprising:(a) placing a first sampling chamber and electrode in electrical communication with a first tissue surface of the subject;(b) conducting electrical current through the first tissue surface in a first polarity;(c) reversing the polarity and conducting electrical current through the tissue at a second polarity,wherein at least one of the steps (b) and (c) extract a substance from the tissue of the subject into the first sampling chamber; and(d) analyzing the first sampling chamber for the concentration of the substance or a substance metabolite after at least one of steps (b) and (c);(e) repeating steps (b) through (d).