초록 ▼

Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical synthese

Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

대표청구항 ▼

[ What is claimed:] [1.] A method for detecting the occurrence of a reaction, comprising:contacting one reactant in the reaction with a matrix-with-memory comprising a remotely-readable recording device disposed on or within a matrix material, wherein the matrix material comprises particles or beads

[ What is claimed:] [1.] A method for detecting the occurrence of a reaction, comprising:contacting one reactant in the reaction with a matrix-with-memory comprising a remotely-readable recording device disposed on or within a matrix material, wherein the matrix material comprises particles or beads or the matrix material comprises a container selected from the group consisting of vials, test tubes, culture dishes, vessels of a volume of about 100 ml or less, and microtiter plates or the matrix material is in the form of a continuous surface, and wherein the matrix material further comprises luminescent moieties, wherein the recording device further comprises means to detect occurrence of the reaction and record the occurrence in the memory of the recording device; anddetecting occurrence of the reaction of the reactant.