초록 ▼

Described herein is a particular type of pharmaceutical tablet, for oral use, which is formed by one or more layers, and is specifically designed for controlled release of active principles that present problems of bio-availability linked to absorption in the gastro-intestinal tract, and in particul

Described herein is a particular type of pharmaceutical tablet, for oral use, which is formed by one or more layers, and is specifically designed for controlled release of active principles that present problems of bio-availability linked to absorption in the gastro-intestinal tract, and in particular active principles that present an erratic and unpredictable absorption linked to the presence or absence of food at the level of the stomach and/or of the first portion of the small intestine, the said pharmaceutical form being characterized in that it is completely coated with one or more films of a biocompatible and biodegradable polymeric material.

대표청구항 ▼

[ We claim:] [1.] A pharmaceutical tablet designed for the controlled release of active principles which exhibits a different biological absorption rate in the presence and in the absence of food, which comprises: a core having one or more layers, at least one of which serves as a vehicle for the ac

[ We claim:] [1.] A pharmaceutical tablet designed for the controlled release of active principles which exhibits a different biological absorption rate in the presence and in the absence of food, which comprises: a core having one or more layers, at least one of which serves as a vehicle for the active principle, while the other layer or layers, selected from the group consisting of erodible, gellable, and erodible and gellable hydrophilic polymers, function as a barrier, being initially impermeable to the passage of the active principle and said tablet being completely coated with one or more films of a biocompatible and biodegradable polymeric material, at least one of said films being of a gastro-resistant and entero-soluble material selected from the group consisting of: cellulose acetophthalate, cellulose acetopropionate, cellulose trimellitate, copolymers of methacrylic and acrylic acids, copolymers of methacrylic acid and methylmethacrylate and methylvinylether-maleic anhydride copolymers.