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Pharmaceutical therapeutic use of glutathione derivative 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/00
  • C07K-005/00
  • C07K-007/00
출원번호 US-0915449 (1997-08-20)
우선권정보 DE-3722647 (1987-07-09)
발명자 / 주소
  • Ohlenschlager Gerhard,DEX
대리인 / 주소
    Alston & Bird LLP
인용정보 피인용 횟수 : 35  인용 특허 : 6

초록

Methods of adjusting or maintaining the intracellular levels of glutathione of a subject are provided. The subject is treated by administering an effective amount of an acetyl derivative of glutathione.

대표청구항

[ I claim:] [1.] A method for increasing or maintaining intracellular concentration of reduced glutathione in a subject, comprising administering to said subject a thiol derivative of glutathione of the formula [ STR 6 ] or a pharmaceutically acceptable salt thereof in an amount effective to increas

이 특허에 인용된 특허 (6)

  1. Crystal Ronald G. (Potomac MD), Aerosol preparation of glutathione and a method for augmenting glutathione level in lungs.
  2. Ohmori Shinji (Okayama JPX) Ogata Kazumi (Toyonaka JPX) Sakaue Takahiro (Itami JPX), Antihepatopathic composition.
  3. Kalopissis Gregoire (Paris FR) Bouillon Claude (Eaubonne FR), Cosmetic compositions for treating the hair containing S-substituted derivatives of glutathione.
  4. Joullie Maurice (Saint-Germain-en-Laye FR) Lakah Lucien (Paris FR) Maillard Gabriel (Paris FR) Muller Pierre (Paris FR), Cysteine derivatives.
  5. Means Gary E. (Columbus OH) Park Jeen W. (Albany CA), Nitrosothiols as hypotensive agents.
  6. Dereu Norbert (Frechen-Bachem DEX) Welter Andr (Pulheim DEX) Wendel Albrecht (Tbingen DEX) Leyck Sigurd (Tbingen DEX) Parnham Michael (Pulheim DEX) Graf Erich (Kerpen DEX) Sies Helmut (Neuss DEX) Bet, S-(carbamoyl-phenylselenyl) derivatives of glutathione and of aminomercaptocarboxylic acids.

이 특허를 인용한 특허 (35)

  1. Schmidt, David, Apparatus and method of stimulating elevation of glutathione levels in a subject.
  2. Schmidt, David G., Apparatus and method of stimulating elevation of glutathione levels in a subject.
  3. Schmidt, David G., Apparatus and method of stimulating elevation of glutathione levels in a subject.
  4. Schmidt, David, Biomolecular wearable apparatus.
  5. Schmidt, David, Biomolecular wearable apparatus.
  6. Garner, William; Garner, Margaret; Blum, Ronald D., Caged mercaptan and seleno-mercaptan compounds and methods of using them.
  7. Ogawa,Kenichi; Henmi,Kenji; Tasaka,Yasushi, Cell-or organ-differentiation controllers and method of controlling morphogenesis by using the same.
  8. Garner, William; Garner, Margaret; Minno, George; Gooden, David, Choline esters.
  9. Garner, William; Garner, Margaret; Minno, George; Gooden, David, Choline esters.
  10. Ogawa, Kenichi; Henmi, Kenji; Iwasaki, Aya, Compound for increasing amino acid content in plant, and use thereof.
  11. Garner, William; Garner, Margaret; Blum, Ronald D., Dithiol compounds and treatment of presbyopia using said compounds.
  12. Garner, William; Garner, Margaret; Blum, Ronald D., Dithiol compounds, derivatives, and treatment of presbyopia.
  13. Garner, William; Garner, Margaret; Minno, George; Gooden, David, Dithiol compounds, derivatives, and uses therefor.
  14. Garner, William; Garner, Margaret, Low dose lipoic acid pharmaceutical compositions and methods.
  15. Garner, William; Garner, Margaret, Low dose lipoic and pharmaceutical compositions and methods.
  16. Hobbe Friso Smit NL; Klaske van Norren NL; Robert Johan Joseph Hageman NL, Method of increasing the presence of glutathione in cells.
  17. Garner, William; Garner, Margaret; Minno, George; Gooden, David, Method of treating presbyopia using dithiol compounds and their derivatives.
  18. Nagasawa, Herbert T.; Cohen, Jonathan F., Methods for reducing oxidative stress in a cell with a sulfhydryl protected glutathione prodrug.
  19. Garner, William; Garner, Margaret; Minno, George; Blum, Ronald D.; Gooden, David, Methods of treating ocular diseases using derivatives of lipoic acid.
  20. Garner, William; Garner, Margaret; Minno, George; Gooden, David, Methods of treating ocular diseases using derivatives of lipoic acid.
  21. Demopoulos Harry B. ; Seligman Myron L., Pharmaceutical preparations of glutathione and methods of administration thereof.
  22. Harry B. Demopoulos ; Myron L. Seligman, Pharmaceutical preparations of glutathione and methods of administration thereof.
  23. Ogawa, Kenichi; Henmi, Kenji, Plant growth regulator and use thereof.
  24. Mrksich, Milan; Hodneland, Christian, Polypeptide immobilization.
  25. Mrksich, Milan; Hodneland, Christian, Polypeptide immobilization.
  26. Mrksich,Milan; Hodneland,Christian, Polypeptide immobilization.
  27. Till, Jonathan S.; Blum, Ronald D., Presbyopia treatment by lens alteration.
  28. Till, Jonathan S.; Blum, Ronald D.; Burns, William R., Presbyopia treatment by lens alteration.
  29. Till, Jonathan S.; Blum, Ronald D., Presbyopia treatment by lens alteration of disulfide bonds and reduction.
  30. Theodore Hersh ; Michael A. Warshaw, Reparatives for ultraviolet radiation skin damage.
  31. Cyr,John E., Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy chromans.
  32. Cyr, John E., Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy-chromans.
  33. Cyr, John E.; Pearson, Daniel A., Stabilization of radiopharmaceutical compositions using hydrophilic thioethers.
  34. Cyr,John E.; Pearson,Daniel A., Stabilization of radiopharmaceutical compositions using hydrophilic thioethers.
  35. Cyr,John E.; Pearson,Daniel A., Stabilization of radiopharmaceutical compositions using hydrophilic thioethers and hydrophilic 6-hydroxy chromans.
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