Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated metal substrate materials, and coated medical devices
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B32B-015/08
출원번호
US-0126374
(1998-08-27)
발명자
/ 주소
Hostettler Fritz
Rhum David
Forman Michael R.
Helmus Michael N.
Ding Ni
출원인 / 주소
Schneider (USA) Inc.
대리인 / 주소
Vidas, Arrett & Steinkraus
인용정보
피인용 횟수 :
16인용 특허 :
26
초록▼
A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenacio
A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
대표청구항▼
[ We claim:] [1.] A material bearing thereon a coating of a lubricious, hydrated hydrophilic polyurethane-polyurea hydrogel, said material being produced by a process comprising the steps of:a) making a surface of a metal substrate reactive by affixing reactive chemical functional groups thereto, at
[ We claim:] [1.] A material bearing thereon a coating of a lubricious, hydrated hydrophilic polyurethane-polyurea hydrogel, said material being produced by a process comprising the steps of:a) making a surface of a metal substrate reactive by affixing reactive chemical functional groups thereto, at least a portion of which are amine-containing groups;b) coating a reactive metal substrate surface which results from step (a) with a first coating comprising a hydrophilic polyurethane prepolymer intermediate, containing terminal isocyanate groups, such that at least a portion of said terminal isocyanate groups are reacted with and are covalently bonded to said reactive chemical functional groups on said substrate surface, forming covalent polyurea bonds therewith, resulting in the formation of a tie coat of a polyurethane-polyurea hydrogel-forming polymer, on said substrate surface, that adheres to said substrate surface, and wherein at least a portion of said terminal isocyanate groups of said polyurethane prepolymer intermediate are present in said polyurethane-polyurea hydrogel-forming polymer such that they remain free to react with other species; andc) coating a tie coat of the first-coated substrate surface which results from step (b) with a second coating comprising a moisture-containing, hydrogel-forming compound or mixture, which contains isocyanate-reactive functional groups, such that a barrier coat of a lubricious, hydrated hydrogel is formed upon the application of said second coating to said tie coat;wherein said moisture of said hydrogel-forming compound or mixture is bound with said polyurethane-polyurea hydrogel-forming polymer of said tie coat to form a hydrogel of said barrier coat, on said tie coat, such that said hydrogel is a polyurethane-polyurea polymer hydrogel; andwherein said isocyanate-reactive functional groups of said hydrogel-forming compound or mixture are reacted with and are covalently bonded to at least a portion of said terminal isocyanate groups of said polyurethane-polyurea hydrogel-forming polymer that remain free to react with other species, thereby directly attaching said polyurethane-polyurea polymer hydrogel to said tie coat and thus also indirectly attaching to said substrate surface.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (26)
Micklus ; Michael J. ; Ou-Yang ; David T., Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same.
Caldwell Karin D. (Salt Lake City UT) Chu Tun-Jen (Salt Lake City UT) Pitt William G. (Orem UT), DNA sequencing using fluorescence background electroblotting membrane.
Karakelle Mutlu (Dayton OH) Karimi Houshang (Kettering OH) Lee Min-Shui (Spring Valley OH) Taller Robert A. (Centerville OH), Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings.
Williams Joel L. (Cary NC) Dunn Terry S. (Raleigh NC) O\Connell James P. (Chapel Hill NC) Montgomery David (Cary NC), Heparinization of plasma treated surfaces.
Creasy Walter S. (Bridgewater NJ) Lorenz Donald H. (Basking Ridge NJ) LaCasse Robert G. (North Plainfield NJ) Malagreca Salvatore A. (Staten Island NY), Hydrophilic polymer blend.
Winters Suzanne (Salt Lake City UT) Solen Kenneth A. (Orem UT) Sanders Clifton G. (Salt Lake City UT) Mortensen J. D. (Sandy UT) Berry Gaylord (Salt Lake City UT), Multifunctional thrombo-resistant coatings and methods of manufacture.
Solomon Donald D. (Spring Valley OH) McGary Charles W. (Centerville OH) Pascarella Vincent J. (Dayton OH), Permanently bonded antithrombogenic polyurethane surface.
Hostettler Fritz (Lambertville NJ) Rhum David (New York NY) Forman Michael R. (Ramsey CA) Helmus Michael N. (St. Louis Park MN) Ding Ni (Plymouth MN), Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel c.
Hostettler Fritz (New York NY) Rhum David (New York NY) Forman Michael R. (New York NY) Helmus Michael N. (New York NY) Ding Ni (New York NY), Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel c.
Braatz James A. (Beltsville MD) Heifetz Aaron H. (Columbia MD) Kehr Clifton L. (Silver Spring MD) Wolfe Richard A. (Ellisville MO), Protein non-adsorptive polyurea-urethane polymer coated devices.
Narayanan Pallassana V. (Davie FL) Stanley Kimberly D. (Florida City FL), Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents.
Nazarova, Irina; Lindquist, Jeffrey S.; Horn, Daniel J., Hydrophilic coating that reduces particle development on ester-linked poly(ester-block-amide).
※ AI-Helper는 부적절한 답변을 할 수 있습니다.