초록 ▼

A housing is secured to an area of skin to allow suction to be applied to a local area of skin through an aperture. After formation of a suction blister, a blade is actuated to sever a suction cup thereby detaching the means for creating suction at the aperture and at the same time removing the roof

A housing is secured to an area of skin to allow suction to be applied to a local area of skin through an aperture. After formation of a suction blister, a blade is actuated to sever a suction cup thereby detaching the means for creating suction at the aperture and at the same time removing the roof of the suction blister to expose an area of dermis from which the skin's epidermis has been removed. A rotatable portion of the apparatus is then moved into a position in which a port communicates with a compartment within the rotatable portion. The compartment may contain a reservoir of fluid substance to be transdermally absorbed or may contain means for taking a sample of exudate produced at the exposed dermis. A modified apparatus has means for applying suction to the exposed dermis to enhance the rate at which exudate is formed and for handling a sample of exudate for analysis. Transdermal delivery and sampling are thereby achieved non-invasively and without the impediment of the skin's epidermis.

대표청구항 ▼

[ What is claimed is:] [1.] A transdermal perfusion apparatus, comprising:a housing including a base having a skin contact surface that defines an aperture, and further including a moveable portion that defines an access port and at least one opening and which includes at least one compartment;means

[ What is claimed is:] [1.] A transdermal perfusion apparatus, comprising:a housing including a base having a skin contact surface that defines an aperture, and further including a moveable portion that defines an access port and at least one opening and which includes at least one compartment;means for operably securing said skin contact surface in sealing contact with an area of skin to be transdermally perfused;wherein in a first position of said moveable portion, said access port is alignable in registration with said aperture to facilitate formation of a de-epithelialized skin erosion within said aperture; andwherein in a second position of said moveable portion, one said opening is alignable in registration with said aperture to provide communication between said aperture and said compartment.