초록 ▼

Specific, selective inhibitors of catalytic antibodies both synthetic and naturally occurring, their use and compositions thereof are disclosed. In particular, an inhibitor preventing the hydrolysis of the peptide bond between amino acid residues 16 and 17 in the neurotransmitter vasoactive intestin

Specific, selective inhibitors of catalytic antibodies both synthetic and naturally occurring, their use and compositions thereof are disclosed. In particular, an inhibitor preventing the hydrolysis of the peptide bond between amino acid residues 16 and 17 in the neurotransmitter vasoactive intestinal peptide (VIP) by an anti-VIP catalytic autoantibody is disclosed.

대표청구항 ▼

[ We claim:] [1.] An inhibitor which inhibits an antibody from catalyzing the cleavage or formation of a peptide bond in a substrate, said inhibitor selected from the group consisting of(a) a fragment of the substrate, (b) an analog of a fragment of the substrate, and (c) an analog of the substrate,

[ We claim:] [1.] An inhibitor which inhibits an antibody from catalyzing the cleavage or formation of a peptide bond in a substrate, said inhibitor selected from the group consisting of(a) a fragment of the substrate, (b) an analog of a fragment of the substrate, and (c) an analog of the substrate, provided that said inhibitor is not the substrate.