초록 ▼

Molecular cross-linked gels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such molecular gels may be applied to target sites in a patient's body by extruding the gel through an orifice at the target site. Alternatively, the gels

Molecular cross-linked gels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such molecular gels may be applied to target sites in a patient's body by extruding the gel through an orifice at the target site. Alternatively, the gels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.

대표청구항 ▼

[ What is claimed is:] [1.] A method for sealing a tissue tract, said method comprising at least partly filling a tissue tract with a fragmented hydrogel hydrated at less than its equilibrium swell, said fragmented hydrogel comprising subunits having sizes from 0.05 mm to 5 mm when fully hydrated an

[ What is claimed is:] [1.] A method for sealing a tissue tract, said method comprising at least partly filling a tissue tract with a fragmented hydrogel hydrated at less than its equilibrium swell, said fragmented hydrogel comprising subunits having sizes from 0.05 mm to 5 mm when fully hydrated and an equilibrium swell from 400% to 1300%, wherein said hydrogel degrades in the tissue tract after from 1 to 120 days.