초록 ▼

A bioerodible polymeric semi-IPN alloy which comprises a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation; a second bioerodible polymer, which provides a biopolymeric scaffolding or internal reinforcement; and optionally a buffering compound that buffers the

A bioerodible polymeric semi-IPN alloy which comprises a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation; a second bioerodible polymer, which provides a biopolymeric scaffolding or internal reinforcement; and optionally a buffering compound that buffers the acidic products within a desired pH range. In a preferred embodiment, the second bioerodible polymer comprises polypropylene fumarate (PPF), which is cross-linked, desirably by a vinyl monomer such as vinyl pyrrolidone (VP) to form the biopolymeric scaffolding which provides the semi-IPN with dimensional and geometric stability.

대표청구항 ▼

[ What is claimed is:] [1.] A two part bioerodible bone cement system which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, said two part cement system consisting ofa) a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrol

[ What is claimed is:] [1.] A two part bioerodible bone cement system which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, said two part cement system consisting ofa) a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation, crosslinking initiator, and a therapeutically effective amount of a biologically active or therapeutic agent, wherein said biologically active or therapeutic agent is in a protective coating of said first bioerodible polymer; andb) a second part comprising a second bioerodible scaffolding polymer, which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, and crosslinking agent for said second bioerodible scaffolding polymer.