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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0953817 (1997-10-20) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 710 인용 특허 : 17 |
Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the foll
Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the following: means for replenishing the enzyme solution as it is consumed by the enzymatic reaction; means for replenishing the electrolyte solution bathing the electrode assembly; and microprocessing means proximal the electrode assembly. In preferred embodiments a microprocessor assembly is hermetically associated with the substrate to which the electrode assembly is affixed. Further, the monitoring systems employ one or more reservoir systems in fluid communication with enzyme and electrolyte chambers wherein the enzyme and electrolyte solutions are used. In a further embodiment, the monitoring systems use enzyme and electrolyte reservoir bulbs in fluid communication with the enzyme and electrolyte reservoirs, respectively, and positioned near the skin surface, thereby providing ready access to the enzyme and electrolyte solutions without the need for explantation of the device. Further provided herein is an enzyme solution including microspheres in association with the enzyme; whereby the enzyme is immobilized by the microspheres and the microspheres are in a fluid, flowable solution. Also provided herein is a method of extending the useful life of an implantable enzyme-based monitoring system, which method includes providing means, within the system, to replenish the enzyme and/or electrolyte solution.
[ What is claimed is:] [1.] An implantable monitoring system comprising an enzyme solution and a reservoir, within the monitoring system, for replenishing the enzyme system; further comprising a sensor assembly for sensing a concentration of a substance being monitored; wherein said sensor assembly
[ What is claimed is:] [1.] An implantable monitoring system comprising an enzyme solution and a reservoir, within the monitoring system, for replenishing the enzyme system; further comprising a sensor assembly for sensing a concentration of a substance being monitored; wherein said sensor assembly includes a plurality of electrodes on a first side of a substrate and at least one hermetically sealed microprocessor on a second side of the substrate; and further comprising hermetically sealed and electrically insulated conductive pathways from the at least one microprocessor to the plurality of electrodes; further comprising said electrode assembly bathed in an electrolyte solution; further comprising hermetically sealed and electrically insulated leads to a command center that supplies electrical power to the sensor assembly.
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