초록 ▼

Varying the daily dose of either or both of the estrogen and the progestogen administered for hormone replacement therapy (HRT) is readily and inexpensively accomplished, without the necessity of the physician prescribing a new product each time the daily dose of the estrogen or progestogen is chang

Varying the daily dose of either or both of the estrogen and the progestogen administered for hormone replacement therapy (HRT) is readily and inexpensively accomplished, without the necessity of the physician prescribing a new product each time the daily dose of the estrogen or progestogen is changed, by administering preferably transdermally the estrogen and the progestogen contained in separate extrudable pharmaceutical compositions from a dispenser which contains means, preferably adjustable only by the attending physician or dispensing pharmacist, for varying the volume of either or both of the respective compositions which is dispensed as a single dose from the dispenser in response to a defined digital dispensing manipulation of the dispenser thereby facilitating optimal compliance to a combination of HRT with individually adjusted dosages of the estrogen and progestogen.

대표청구항 ▼

[ What is claimed is:] [1.] An hormone replacement therapy (HRT) device for self-administration by a human female of a plurality of successive doses of an estrogen and a plurality of successive doses of a progestogen, wherein the female dispenses and self-administers successive individual doses of t

[ What is claimed is:] [1.] An hormone replacement therapy (HRT) device for self-administration by a human female of a plurality of successive doses of an estrogen and a plurality of successive doses of a progestogen, wherein the female dispenses and self-administers successive individual doses of the estrogen and of the progestogen over a protracted period of time, during which period of time the amount of at least one of which doses is changed, which device comprises:a first containerized source of a first extrudable pharmaceutically acceptable composition containing a plurality of non-discrete doses of the estrogen,a first meter for measuring and determining the volume of the dispensed doses of estrogen; a first adjuster for varying the volume of the first extrudable pharmaceutical composition;a second containerized source of a second extrudable pharmaceutically acceptable composition containing a plurality of non-discrete doses of the progestogen;a second meter for measuring and determining the volume of the dispensed doses of progestogen; a second adjuster for varying the volume of the second extrudable pharmaceutical composition;the first and second meters being in proximity with one another wherein measured doses of estrogen and progestogen are immediately available for topical application by the patient so as to facilitate a protocol for self-administration of the estrogen and progestogen on a repeated schedule, periodically in response to the physiological symptoms associated with menopause or the hormone replacement therapy currently exhibited by the female, so that the metered volume of at least one of the first and second compositions may be dispensed.