초록 ▼

A method and apparatus for analyzing molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. The invention is also directed to a method and apparatus for constructing molecular arrays having a plurality of test sites.

A method and apparatus for analyzing molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. The invention is also directed to a method and apparatus for constructing molecular arrays having a plurality of test sites. The invention allows for definitive high throughput analysis of multiple analytes in complex mixtures of sample substances. A combinatorial analysis process is described that results in the creation of an array of integrated chemical devices. These devices operate in parallel, each unit providing specific sets of data that, when taken as a whole, give a complete answer for a defined experiment. This approach is uniquely capable of rapidly providing a high density of information from limited amounts of sample in a cost-effective manner.

대표청구항 ▼

[ What is claimed is:] [1.] A device for preparing a reaction substrate having biosites for conducting multiplexed microassays to determine binding between a target analyte and a capture probe, including:a plurality of capillary tubes, each tube having a proximal end and a distal end;an attachment s

[ What is claimed is:] [1.] A device for preparing a reaction substrate having biosites for conducting multiplexed microassays to determine binding between a target analyte and a capture probe, including:a plurality of capillary tubes, each tube having a proximal end and a distal end;an attachment site for holding said capillary tubes at a point spaced from the distal ends of such capillary tubes;an array template for slidably holding each capillary tube near its distal end, and for allowing the distal end of each capillary tube to move with respect to the attachment site;at least one manifold for positioning the proximal end of each capillary tube within a corresponding supply chamber, wherein each supply chamber is capable of supplying a liquid reagent to at least one corresponding capillary tube; anda positioning device for precisely positioning the array template and said capillary tubes with respect to said reaction substrate and depositing liquid reagents from said distal end of said capillary tubes onto said reaction substrate as biosites.