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Macromolecular microparticles and methods of production and use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-017/02
  • C07K-001/00
  • C08H-001/02
  • G01N-033/544
출원번호 US-0699586 (1996-08-19)
발명자 / 주소
  • Woiszwillo James E.
  • Brown Larry R.
  • Scott Terrence L.
  • Di Jie
  • Sudhalter Judith
  • Blizzard Charles D.
출원인 / 주소
  • Epic Therapeutics, Inc.
대리인 / 주소
    Jones & Askew, LLP
인용정보 피인용 횟수 : 180  인용 특허 : 378

초록 ▼

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol

대표청구항

[ We claim:] [1.] A method of making microparticles comprising combining a macromolecule and a polymer in an aqueous solution at a pH near the isoelectric point of the macromolecule and exposing the solution to an energy source for a sufficient amount of time to form microparticles.

이 특허에 인용된 특허 (378)

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  • Habibi Hamid R.,CAX, Inhibition of liver cancer by the use of GnRH and GnRH analogs.
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  • Orly Isabelle (Lyons FRX) Huc Alain (Ste Foy les Lyon FRX), Injectable compositions containing collagen microcapsules.
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  • Oppenheim ; Richard Charles ; Marty ; Jennifer Joy ; Speiser ; Peter, Injectable compositions, nanoparticles useful therein, and process of manufacturing same.
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  • Passeron Eduardo Julio,ARX ITX 1634 ; Gellon Alberto Atilio,ARX ITX 1430 ; Taroni Elbio Humberto,ARX ITX 1008, Injectable pulsatile ivermectin composition.
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  • Tice Thomas R. (Birmingham AL) Lewis Danny H. (Gardendale AL) Cowsar Donald R. (Birmingham AL) Beck Lee R. (Birmingham AL), Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents.
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  • Sakamoto Izumi (Kyoto JPX) Takagi Kunihiko (Kyoto JPX), Injector filled with an anti-cancer composition.
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  • Bousquet Hubert (Caluire FRX) Egraz Jean Bernard (Lyons FRX) Ravet Georges (St. Genis les Ollieres FRX), Isodiametrical microcapsules with regularized diameters and process for producing same.
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  • Daniel Jean-Claude (Fontenay-sous-Bois FR), Latex of styrene polymers with terminal amino-sulfonated groups and method of making.
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  • Hubbell Jeffrey A. (Austin TX) Hill-West Jennifer L. (Austin TX) Dunn Randall C. (Houston TX), Local delivery of fibrinolysis enhancing agents.
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  • Nestor John J. (San Jose CA) Vickery Brian H. (Cupertino CA), Long acting depot injectable formulations for LH-RH analogues.
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  • Phillips Christopher P. (Brandamore PA) Snow Robert A. (West Chester PA), Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life.
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  • Phillips Christopher P. (Brandamore PA) Snow Robert A. (West Chester PA), Lyophilized polyethylene oxide modified protein and polypeptide complexes with cyclodextrin.
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  • Bordier Thierry (Tremblay FRX) Philippe Michel (Wissous FRX), Lysine derivatives, process of preparation, uses, and compositions comprising them.
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  • Igari Yasutaka (Hyogo JPX) Saikawa Akira (Osaka JPX) Okamoto Kayoko (Osaka JPX) Kamei Shigeru (Hyogo JPX) Oka Masahisa (Kanagawa JPX) Sano Atsunori (Saitama JPX), Matrix for sustained-release preparation.
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  • Igari Yasutaka (Hyogo JPX) Saikawa Akira (Osaka JPX) Okamoto Kayoko (Osaka JPX) Kamei Shigeru (Hyogo JPX) Oka Masahisa (Kanagawa JPX) Sano Atsunori (Saitama JPX), Matrix for sustained-release preparation.
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  • Pike Malcolm C. (Long Beach CA) Spicer Darcy V. (Pasadena CA), Method and formulations for use in treating benign gynecological disorders.
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  • Dapper Gregory S. (Newark CA) Yamamoto Ronald K. (San Francisco CA), Method for forming controlled release polymeric substrate.
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  • Zolle Ilse (Lazarettgasse 14A Vienna 1090 OE), Method for incorporating substances into protein microspheres.
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  • Violanto Michael R. (Rochester NY), Method for making uniformly sized particles from water-insoluble organic compounds.
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  • Zuckerkandl Emile (Palo Alto CA), Method for preparing a macromolecular monoclonal antibody composition.
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  • Lafon Louis (Paris FRX), Method for preparing galenic formulations particularly for pharmaceutical, dietetical, cosmetic and diagnostic uses.
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  • Ishiguro Mamoru (Takasago JPX) Murakami Yoshihide (Takasago JPX), Method for producing microcapsules.
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  • Mathiowitz Edith (Brookline MA) Bernstein Howard (Cambridge MA) Morrel Eric (Needham MA) Schwaller Kirsten (Duxbury MA), Method for producing protein microspheres.
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  • Ekman Bo (MalmSEX) Lindahl ke (Skurup SEX), Method for producing small, spherical polymer particles.
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  • Rodgers Kathleen Elizabeth (Long Beach CA) diZerega Gere Stodder (Pasadena CA), Method for reducing or preventing post-surgical adhesion formation using manoalide and analogs thereof.
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  • Tice Thomas R. (Birmingham AL) Dillon Deborah L. (Helena AL) Mason David W. (Birmingham AL) McRae-McFarlane Amanda (Vastra Frolunda SEX) Dahlstrom Annica B. (Askin SEX), Method for stimulating nerve fiber growth.
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  • Moriwaki Masafumi (Uenohara JPX) Etoh Kei (Tokyo JPX) Sekihara Hiroyuki (Hino JPX), Method for the preparation of microcapsules.
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  • Brizzolara Nancy S. (Congers NY) Lanzilotti Michael G. (Pearl River NY) Lawter James R. (Goshen NY), Method for the treatment of periodontal disease by sustained delivery of a therapeutic agent to the periodontal pocket,.
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  • Kraemer Dieter (Mainz DT) Lehmann Klaus (Rossdorf ; Darmstadt DT) Plainer Hermann (Darmstadt DT), Method of bonding a polypeptide to a macromolecular polymeric carrier by irradiation with light.
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  • Dorman Linneaus C. (Midland MI), Method of coupling a protein to a polymer particle containing hydrazide groups in a polymer latex and the products forme.
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  • Dorman Linneaus C. (Midland MI) Mani Inder (Midland MI), Method of coupling a protein to an epoxylated latex.
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  • Jarvis ; Jr. Allan P. (Newburyport MA) Lim Franklin (Richmond VA), Method of culturing anchorage dependent cells.
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  • Tresco Patrick A. (Salt Lake City UT) Mills John F. (Wakefield RI), Method of encapsulating biological substances in microspheres.
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  • Senyei Andrew E. (Chicago IL) Widder Kenneth J. (Chicago IL), Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres.
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  • Edens Frank W. (Raleigh NC) Thaxton James P. (Apex NC), Method of inducing birds to molt.
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  • Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL) Eldridge John H. (Birmingham AL) Staas Jay K. (Birmingham AL) Hollingshead Melinda G. (Birmingham AL) Shannon William M. (Birmingham A, Method of potentiating an immune response.
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  • Engstrom Sven (Lund SEX) Lindman Bjorn (Lund SEX) Larsson Kare (Bjarred SEX), Method of preparing controlled-release preparations for biologically active materials and resulting compositions.
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  • Gorissen Elke (Offenburg DEX) Biskup Heike (Langenfeld DEX) Schneider Hannelore (Dusseldorf DEX), Method of producing microscopic particles made of hydrolytically decomposable polymers and containing active substances.
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  • Lencki Robert W. J. (1650 Lincoln Ave. ; Apt. 1101 Montreal ; Quebec CAX H3H 1H1) Neufeld Ronald J. (110 Westbank Ave. Pointe Claire ; Quebec CAX H9R 2X6) Spinney Trevor (3739 St. Dominique Montreal , Method of producing microspheres.
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  • Kamei Shigeru (Takarazuka JPX) Yamada Minoru (Kawanishi JPX) Ogawa Yasuaki (Ohyamazaki-cho JPX), Method of producing sustained-release microcapsules.
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  • Kamei Shigeru,JPX ; Yamada Minoru,JPX ; Ogawa Yasuaki,JPX, Method of producing sustained-release microcapsules.
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  • Igari Yasutaka (Kobe JPX) Yamamoto Kazumichi (Nara JPX) Okamoto Kayoko (Osaka JPX) Yamagata Yutaka (Kobe JPX), Method of producing sustained-release preparation.
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  • Kantor Martin L., Method of solubilizing and encapsulating itraconazole.
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  • Labrie Fernand (Quebec CAX) Raynaud Jean-Pierre (Paris FRX), Method of treating hormonal dependent mammary tumors in female mammals.
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  • Labrie Fernand (Quebec CAX) Raynaud Jean-Pierre (Paris FRX), Method of treating precocious puberty.
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  • Labrie Fernand (Quebec CAX) Raynaud Jean-Pierre (Paris FRX), Method of treating precocious puberty.
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  • Labrie Fernand (Quebec CAX) Raynaud Jean-Pierre (Paris FRX), Method of treating prostate adenocarcinoma, prostate benign hypertrophia and endometriosis.
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  • Liversidge Gary G. (West Chester PA) Phillips Christopher P. (Brandamore PA) Cundy Kenneth C. (Belmont CA), Method to reduce particle size growth during lyophilization.
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  • Perlman Daniel (Arlington MA), Methods for isolating mutant microoganisms using microcapsules coated with indicator material.
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  • Frensch Heinz (Frankfurt am Main DEX) Albrecht Konrad (Frankfurt am Main DEX) Hook Klaus (Frankfurt am Main DEX), Micro granules for pesticides and process for their manufacture.
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  • Ekman Bo M. (MalmSEX) Larsson Kare V. (Bjrred SEX) Lindahl Ake R. (Skurup SEX) Rothman Ulf S. E. (Skanr SEX), Micro-capsules.
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  • Nastke Rudolf (Rehbrucke DEX) Leonhardt Andreas (Freiburg DEX) Neuenschwander Ernst (Riehen CHX), Microcapsulated pesticidal formulations, their preparation and use.
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  • Zsifkovits Wilhelm (Korneuburg ATX) Grning Burghard (Essen DEX) Kollmeier Hans-Joachim (Essen DEX) Schaefer Dietmar (Essen DEX) Weitemeyer Christian (Essen DEX), Microcapsule and micromatrix bodies and method for their formation.
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  • Takizawa Masahiro (Kitasaitama JPX) Takahashi Hideyuki (Chiba JPX), Microcapsule containing hydrous composition.
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  • Stewart Ray F. (Redwood City CA) Greene Lawrence C. (Boulder Creek CA) Bhaskar Ravi K. (Lawrence KS), Microcapsule having temperature-dependent permeability profile.
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  • David Jacky (Isle Sorgue FRX) Lefrancois Claudine (La Haye du Puits FRX) Ridoux Claude (Isle sur Sorgue FRX), Microcapsules based on gelatin and polysaccharides and process for obtaining same.
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  • Soon-Shiong Patrick ; DeSai Neil P. ; Sandford Paul A. ; Heintz Roswitha A. ; Sojomihardjo Soebianto, Microcapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and use therefor.
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  • Levy Marie-Christine,FRX ; Andry Marie-Christine,FRX, Microcapsules with a wall of crosslinked plant polyphenols and compositions containing them.
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  • Mesens Jean,BEX ; Rickey Michael E. ; Atkins Thomas J., Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles 1,2-benzisothiazoles.
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  • Ohtsubo Toshiro (Hyogo JPX) Tsuda Shigenori (Kyoto JPX) Kawada Hitoshi (Osaka JPX) Shinjo Goro (Osaka JPX) Tsuji Kozo (Nara JPX), Microencapsulated cockroach-controlling composition.
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  • Valenti Mauro (Magenta ITX), Microencapsulation of a medicament.
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  • Kent John S. (Cupertino CA) Lewis Danny H. (Birmingham AL) Sanders Lynda M. (Palo Alto CA) Tice Thomas R. (Birmingham AL), Microencapsulation of water soluble active polypeptides.
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  • Janda Joseph (Midlothian IL) Bernacchi Donald (Chicago IL) Frieders Suzanne (Oaklawn IL), Microencapsulation process.
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  • Scher Herbert B. (Moraga CA) Rodson Marius (El Cerrito CA), Microencapsulation process.
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  • Tice Thomas R. (Helena AL) Lewis Danny H. (Gardendale AL), Microencapsulation process.
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  • Thompson William W. (Indianapolis IN), Microparticle compositions containing peptides, and methods for the preparation thereof.
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  • Bontemps Jos (Xhendremael BEX) Pirson Philippe (Wezembeek-Oppem BEX) Falmagne Jean-Bernard (Wavre BEX) Jerome Robert (Tilff BEX) Teyssie Philippe (Condroz BEX) Delattre Luc (Oupeye BEX) Evrard Brigit, Microparticles comprising a biodegradable polymer controlling the release of an antimalaria active principle, pharmaceut.
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  • Hedley Mary Lynne ; Curley Joanne M. ; Langer Robert S., Microparticles for delivery of nucleic acid.
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  • Fernandez Julio M. ; Knudson Mark B., Microparticles with high drug loading.
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  • Lange Wolfgang (Obernburg DEX), Microporous powder form polylactides.
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  • Rembaum Alan (Pasadena CA) Yen Richard C. K. (Glendale CA), Microsphere coated substrate containing reactive aldehyde groups.
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  • Goldberg Eugene P. (Gainesville FL) Longo William E. (Gainesville FL) Iwata Hiroo (Suita JPX), Microspheres for incorporation of therapeutic substances and methods of preparation thereof.
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  • Wantier Henri (Dour BEX) Mathieu Fabienne (Nivelles BEX) Baudrihaye Marc (Waterloo BEX) Delacroix Dominique (Kraainem BEX), Microspheres for the controlled release of water-soluble substances and process for preparing them.
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  • Redlich George H. (Norristown PA) Novak Ronald W. (Chalfont PA), Microsuspension process for preparing solvent core sequential polymer dispersion.
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  • Pera Ivo E. (Pisa ITX), Modification of permeant.
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  • Milstein Sam J. (Larchmont NY) Barantsetvich Evgueni N. (New Rochelle NY), Modified amino acids for encapsulating active agents.
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  • Bernstein Howard (Cambridge MA) Zhang Yan (Cambridge MA) Khan M. Amin (Downingtown PA) Tracy Mark A. (Arlington MA), Modulated release from biocompatible polymers.
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  • Lucas Paul A. (Macon GA) Young Henry E. (Macon GA) Laurenchin Cato T. (Somerville MA), Muscle morphogenic protein and use thereof.
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  • Domb Abraham J. (Efrat ILX) Gref Ruxandra (Nancy FRX) Minamitake Yoshiharu (Ota JPX) Peracchia Maria T. (Parma ITX) Langer Robert S. (Newton MA), Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers.
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  • Spenlehauer Gilles (Cachan FRX) Bazile Didier (Saint Maur des Fosses FRX) Veillard Michel (Sceaux FRX) Prud\Homme Christian (Lyons FRX) Michalon Jean-Paul (Lyons FRX), Nanoparticles based on a polyoxyethelene and polyactic acid block copolymer.
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  • Ahlers Michael (Mainz DEX) Walch Axel (Frankfurt am Main DEX) Seipke Gerhard (Hofheim DEX) Russell-Jones Gregory (Middel Cove AUX), Nanoparticles containing an active substance and a ketalized polytartramidic acid, process for their preparation, and us.
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  • Duheille Jean (Saint-Max FRX) Pau Bernard (Montpellier FRX) Gros Pierre (Montpellier FRX), Nephelometric determination of HBs antigen with antibody-containing microparticles.
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  • Huper Fritz (Wuppertal DT) Rauenbusch Erich (Wuppertal DT) Schmidt-Kastner Gunter (Wuppertal DT) Bomer Bruno (Leverkusen DT) Bartl Herbert (Odenthal-Hahnenberg DT), New water-insoluble preparations of peptide materials, their production and their use.
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  • Yen Richard C. K., Non-crosslinked protein particles for therapeutic and diagnostic use.
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  • Krasnobajew Victor (Zollikerberg CHX) Boeniger Regula (Greifensee CHX), Novel condensation products having high activity to insolubilize proteins and protein-insolubilized products.
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  • Koguchi Toshiro (Yokohama JPX) Kase Hiroshi (Koganei JPX) Kawamoto Isao (Hiratsuka MD JPX) Kasai Masaji (Rockville MD) Shirahata Kunikatsu (Komae JPX) Okachi Ryo (Shizuoka JPX) Nakayama Kiyoshi (Saga, Novel physiologically active substance K-4, a process for preparation thereof and a pharmaceutical composition containin.
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  • Labrie Fernand (Quebec CAX) Raynaud Jean-Pierre (Paris FRX), Novel treatment method.
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  • Lapoiriere Claudine (Le Perreux FRX) Mahieu Claude (Paris FRX) Papantoniou Christos (Montmorency FRX), One step process for preparing cross-linked poly-b 상세보기
  • Milstein Sam J. ; Barantsevitch Evgueni N. ; Sarubbi Donald J. ; Leone-Bay Andrea ; Paton Duncan R., Oral drug delivery compositions and methods.
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  • Ecanow Bernard (Wilmette IL), Oral insulin and a method of making the same.
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  • Angeles Uribe Juan (Mexico MXX) Garza Flores Josue (Mexico MXX), Parenteral dosage form.
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  • Levy Marie-Christine (Reims FRX) Edwards-Levy Florence (Reims FRX) Orly Isabelle (Lyons FRX), Particles prepared by transacylation reaction between an esterified polysaccharide and a polyamine, methods of preparati.
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  • Dohi Masahiko (Hino JPX) Nishibe Yoshihisa (Fuchu JPX) Makino Yuji (Hino JPX) Suzuki Yoshiki (Hino JPX), Peptide proteinaceous drug nasal powder composition.
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  • Nastke Rudolf (Rehbrulke DEX) Leonhardt Andreas (Freiburg DEX) Neuenschwander Ernst (Riehen CHX), Pesticidal formulations.
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  • Canal Tiziana (Trieste ITX) Lovrecich Mara Lucia (Trieste ITX) Carli Fabio (Trieste ITX), Pharmaceutical compositions in the form of particles suitable for the controlled release of pharmacologically active sub.
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  • Boyes Robert N. (St. Albans AL GB2) Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL) Pledger Kenneth L. (Huntsville AL), Pharmaceutical formulations comprising microcapsules.
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  • Garces Jose de los Santos,ESX ; Munoz Angel Bonilla,ESX ; Anton Jose Maria Garcia,ESX, Pharmaceutical preparation for improving the bioavailability of drugs which are difficult to absorb and a procedure for.
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  • Pitha Josef (Baltimore MD), Pharmaceutical preparations containing cyclodextrin derivatives.
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  • Ghebre-Sellassie Isaac (Stanhope NJ) Iyer Uma (Mendham NJ), Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat.
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  • Krone Volker (Florsheim am Main DEX) Magerstadt Michael (Hofheim am Taunus DEX) Walch Axel (Frankfurt am Main DEX) Groner Albrecht (Seeheim-Jugenheim DEX) Hoffmann Dieter (Marburg DEX), Pharmacological composition containing polyelectrolyte complexes in microparticulate form and at least one active agent.
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  • Thorengaard Bitten (Charlottenlund DKX) York David W. (Waterloo BEX), Photoactivator dye composition for detergent use.
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  • Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill-West Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
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  • Ranney David F. (3539 Courtdale Dr. Dallas TX 75234), Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement.
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  • Schlossman David S. (W. Orange NJ), Pigment-material-microsphere complexes and their production.
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  • Rembaum Alan (Pasadena CA), Polyacrolein microspheres.
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  • Margel Shlomo (Rehovot ILX) Beitler Uzi (Rehovot ILX), Polyacrolein-type microspheres.
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  • Speiser Peter (Zurich CHX) Schleuniger Urs (Zurich CHX) Orsolini Piero (Martigny CHX) Heimgartner Frdric (Martigny CHX), Polyester-based composition for the controlled release of polypeptide medicinal substances.
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  • Rembaum Alan (Altadena CA) Margel Shlomo (N. Hollywood CA), Polyglutaraldehyde microspheres.
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  • Rembaum Alan (Altadena CA), Polyglutaraldehyde synthesis and protein bonding substrates.
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  • Hyon Suong-Hyu (Uji JPX) Ikada Yoshita (Uji JPX), Polylactic acid type microspheres containing physiologically active substance and process for preparing the same.
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  • Kashdan David S. (Kingsport TN 37663), Polymer blends having reverse phase morphology for controlled delivery of bioactive agents.
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  • Yamamoto Masaki (Osaka JPX) Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Miyagawa Tsutomu (Saitama JPX), Polymer, production and use thereof.
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  • Yamamoto Masaki (Osaka JPX) Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Miyagawa Tsutomu (Saitama JPX), Polymer, production and use thereof.
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  • Amsden Brian G. (40 Fountainhead Rd. ; Apt. #1516 Downsview ; Ontario M3J 2V1 CAX) Cheng Yu-Ling (1399 Glenburnie Rd. Mississauga Ontario L5G 3C7 CAX), Polymer-based drug delivery system.
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