초록 ▼

A solid phase synthesis method for the preparation of diverse sequences of separate polymers or nucleic acid sequences using electrochemical placement of monomers or nucleic acids at a specific location on a substrate containing at least one electrode that is preferably in contact with a buffering o

A solid phase synthesis method for the preparation of diverse sequences of separate polymers or nucleic acid sequences using electrochemical placement of monomers or nucleic acids at a specific location on a substrate containing at least one electrode that is preferably in contact with a buffering or scavenging solution to prevent chemical crosstalk between electrodes due to diffusion of electrochemically generated reagents.

대표청구항 ▼

[ What is claimed is:] [1.] A method for electrochemical placement of a material at a specific location on a substrate, which comprises the steps of:providing a substrate having at its surface at least one electrode that is proximate to at least one molecule bearing at least one protected chemical f

[ What is claimed is:] [1.] A method for electrochemical placement of a material at a specific location on a substrate, which comprises the steps of:providing a substrate having at its surface at least one electrode that is proximate to at least one molecule bearing at least one protected chemical functional group,placing a buffering or scavenging solution in contact with the electrode at the surface of the substrate to prevent the electrochemically generated reagents from leaving the locality of the electrode,applying a potential to the electrode sufficient to generate electrochemical reagents capable of deprotecting at least one of the protected chemical functional groups, andbonding the deprotected chemical functional group with a monomer or a pre-formed molecule.