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Systems and methods for topical treatment with nitric oxide

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-033/00
출원번호 US-0095174 (1998-06-10)
발명자 / 주소
  • Seitz William A.
  • Garfield Robert E.
  • Balaban Alexandru T.
  • Stewart Randall J.
출원인 / 주소
  • Nitric Oxide Solutions
대리인 / 주소
    Hodgins
인용정보 피인용 횟수 : 215  인용 특허 : 16

초록

A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generat

대표청구항

[ What is claimed is:] [1.] A method for therapeutically applying NO, the method comprising topically applying first gel comprising a nitrite salt, and a biocompatible reductant and a second gel comprising an acid with a pKa between about 1 and about 4 to a body site in an amount effective to enhanc

이 특허에 인용된 특허 (16)

  1. Keefer Larry K. (Bethesda MD) Wink David A. (Frederick MD) Dunams Tambra M. (Frederick MD) Hrabie Joseph A. (Frederick MD), Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof.
  2. Keefer Larry K. (Bethesda MD) Wink David A. (Hagerstown MD) Dunams Tambra M. (Florence AL) Hrabie Joseph A. (Frederick MD), Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof.
  3. Keefer Larry K. (Bethesda MD) Wink David A. (Frederick MD) Dunams Tambra M. (Frederick MD) Hrabie Joseph A. (Frederick MD), Antihypertensive compositions and use thereof.
  4. Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Complexes of nitric oxide with polyamines.
  5. Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Complexes of nitric oxide with polyamines.
  6. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Composition useful for in vivo delivery of biologics and methods employing same.
  7. Tawashi Rashad (66 Hyde Park Beaconsfield ; Quebec CAX H9W 5L8 ), Drug delivery of nitric oxide.
  8. Hrabie Joseph A. (Frederick MD) Keefer Larry K. (Bethesda MD), Method of generating nitric oxide gas using nitric oxide complexes.
  9. Garfield Robert E. (Friendswood TX) Balaban Alexandru T. (Galveston TX) Seitz William A. (Dickinson TX) Klein Douglas J. (Galveston TX) Lesko Melanie (Friendswood TX), N-nitroso-N-substituted hydroxylamines as nitric oxide donors.
  10. Wink ; Jr. David A. ; Mitchell James B. ; Russo Angelo ; Krishna Murali C. ; Hanbauer Ingeborg ; Grisham Matthew B. ; Granger Daniel Neil, Nitric oxide releasing compounds as protective agents in ischemia reperfusion injury.
  11. Smith Daniel J. (Stow OH) Pulfer Sharon (Clinton OH) Shabani Mohammad (Akron OH), Polymeric wound healing accelerators.
  12. Keefer Larry K. (Bethesda MD) Lunn George (Frederick MD), Reductive destruction of nitrosamines, hydrazines, nitramines, azo- and azoxy-compounds.
  13. Keefer Larry K. (Bethesda MD), Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents.
  14. Wellinghoff Stephen T. ; Barenberg Sumner A. ; Dixon Hong ; Kampa Joel J., Sustained release biocidal powders.
  15. Diodati Jean G. (Bethesda MD) Keefer Larry K. (Bethesda MD), Therapeutic inhibition of platelet aggregation by nucleophile-nitric oxide complexes and derivatives thereof.
  16. Mitchell James B. ; Russo Angelo ; Krishna Murali C. ; Wink ; Jr. David A. ; Liebmann James E., Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents.

이 특허를 인용한 특허 (215)

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