Supplemented and unsupplemented tissue sealants, method of their production and use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/48
A61K-009/70
A61L-015/16
출원번호
US-0474086
(1995-06-07)
발명자
/ 주소
MacPhee Martin James
Drohan William Nash
Liau Gene
Haudenschild Christian
출원인 / 주소
The American National Red Cross
대리인 / 주소
Sterne, Kessler Goldstein & Fox P.L.L.C.
인용정보
피인용 횟수 :
148인용 특허 :
60
초록▼
This invention provides supplemented tissue sealants, methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one cytotoxin or cell proliferation inhibiting composition. The composition may be further supplemented with, for example, one or more antibodi
This invention provides supplemented tissue sealants, methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one cytotoxin or cell proliferation inhibiting composition. The composition may be further supplemented with, for example, one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, cytokines, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like.
대표청구항▼
[ What is claimed is:] [1.] A biocompatible, supplemented tissue sealant composition comprising:(i) at least one supplement selected from the group consisting of an antibiotic, an anesthetic, an anticoagulant, a cardiovascular drug, an anti-inflammatory compound, a cytotoxin or cell proliferation in
[ What is claimed is:] [1.] A biocompatible, supplemented tissue sealant composition comprising:(i) at least one supplement selected from the group consisting of an antibiotic, an anesthetic, an anticoagulant, a cardiovascular drug, an anti-inflammatory compound, a cytotoxin or cell proliferation inhibiting compound, an osteogenic compound, a cartilage inducing compound, a protease inhibitor, a steroid, an analgesic, an antifungal, an antiangiogenin, an antifibrinolytic compound, an antimicrobial compound, an antiparasitic agent, an antiseptic, an antiviral compound, a chemotherapeutic drug, a lipid or liposome, an oligonucleotide or polynucleotide, an osteoconductive compound, a polysaccharide, a vasoconstrictor, a vasodilator, a vitamin, a nutritional supplement and a mineral; and(ii) fibrinogen in an amount which forms a fibrin matrix;wherein said fibrinogen forms a fibrin matrix when in the presence of thrombin and Ca.sup.++ and water,further wherein said supplement is released from said fibrin matrix into the external environment of use for a sustained period,further wherein the amount of said supplement in said composition is greater than the amount of said supplement which is soluble in said fibrin matrix, andfurther wherein said sustained period is greater than the period obtained according to simple diffusion kinetics. [2.] A biocompatible, supplemented tissue sealant composition comprising:(i) at least one supplement selected from the group consisting of an antiangiogenin, an antifibrinolytic protein, an antimicrobial protein, a cytokine, a hormone, an interferon, a proteoglycan, a polypeptide, a protease inhibitor, a cytotoxin or cell proliferation inhibiting protein, and a protein nutritional supplement; and(ii) fibrinogen in an amount which forms a fibrin matrix;wherein said fibrinogen will form a fibrin matrix when in the presence of thrombin and Ca.sup.++ and water,further wherein said supplement is released from said fibrin matrix into the external environment of use for a sustained period, andfurther wherein said sustained period is greater than the period obtained according to simple diffusion kinetics. [3.] A biocompatible, supplemented tissue sealant composition comprising:(i) at least one supplement selected from the group consisting of a growth factor, an osteogenic protein, a cartilage inducing protein, an antibody, and an anticoagulant protein; and(ii) fibrinogen in an amount which forms a fibrin matrix;wherein said fibrinogen will form a fibrin matrix when in the presence of thrombin and Ca.sup.++ and water,further wherein said supplement is released from said fibrin matrix into the external environment of use for a sustained period, andfurther wherein said sustained period is greater than the period obtained according to simple diffusion kinetics.
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