Compositions and treatments for reducing potential unwanted side effects associated with long-term administration of androgenic testosterone precursors
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IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
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| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0132359
(1998-08-11)
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발명자
/ 주소 |
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| 출원인 / 주소 |
- Weider Nutrition International, Inc
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| 대리인 / 주소 |
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| 인용정보 |
피인용 횟수 :
28 인용 특허 :
58 |
초록
▼
A method for reducing potential adverse effects of androgenic testosterone precursors by interfering with production or action of testosterone and estrogen metabolites by nutrient combinations is described. Although androgenic testosterone precursors themselves have little or no toxicity, there is t
A method for reducing potential adverse effects of androgenic testosterone precursors by interfering with production or action of testosterone and estrogen metabolites by nutrient combinations is described. Although androgenic testosterone precursors themselves have little or no toxicity, there is the potential for their metabolites, estradiol and dihydrotestosterone, to enhance or cause hormone-responsive illnesses such as breast or prostatic cancer, benign prostatic hyperplasia, or hirsutism or acne in women. The use of the invented nutrient combinations reduces the formation or action of estradiol and dihydrotestosterone, thereby reducing potential adverse effects from increased production of these hormones following androgenic testosterone precursor administration. This may be accomplished without negating the effects of testosterone on muscle anabolism. The nutrient combinations include androstenedione, DHEA, pregnenolone, androstenediols, norandrostenedione and norandrostenediols, and natural products which reduce estrogen effects in the estrogen-responsive tissues, and substances to reduce formation of dihydrotestosterone from testosterone in prostate tissue.
대표청구항
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[ I claim:] [1.] A composition for promoting anabolic growth in humans and mammals, comprising therapeutically effective amounts of:(a) at least one androgenic testosterone precursor selected from the group consisting of .DELTA..sup.4 -androstene-3,17-dione, pregnenolone, dehydroepiandrosterone, .DE
[ I claim:] [1.] A composition for promoting anabolic growth in humans and mammals, comprising therapeutically effective amounts of:(a) at least one androgenic testosterone precursor selected from the group consisting of .DELTA..sup.4 -androstene-3,17-dione, pregnenolone, dehydroepiandrosterone, .DELTA..sup.4 -androstene-3.beta.,17.beta.-diol, .DELTA..sup.5 -androstene-3.beta.,17.beta.-diol, 19-norandrost-4-ene-3,17-dione, 19-norandrost-4-ene-3.beta.,17.beta.-diol, 19-norandrost-5-ene-3.beta.,17.beta.-diol, and pharmaceutically acceptable salts thereof;(b) at least one natural product having anti-estrogen activity selected from the group consisting of green tea, black tea, catechu, extract thereof and powder thereof;(c) at least one substance having anti-DHT activity selected from the group consisting of zinc and pharmaceutically acceptable zinc salts; and(d) a pharmaceutically suitable carrier;wherein said androgenic testosterone precursor promotes anabolic growth while said natural product having anti-estrogen activity reduces estrogen effects associated with the administration of said androgenic testosterone precursor and said substance having anti-DHT activity reduces conversion of said androgenic testosterone precursor to dihydrotestosterone.
이 특허에 인용된 특허 (58)
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Loria Roger M. (3219 Brook Rd. Richmond VA 23227), 5-androstene 3
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