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Sustained release particles 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61F-002/00
출원번호 US-0051709 (1998-04-17)
우선권정보 SE-0003672 (1995-10-19)
국제출원번호 PCT/SE96/01091 (1996-09-03)
§371/§102 date 19980417 (19980417)
국제공개번호 WO-9714408 (1997-04-24)
발명자 / 주소
  • Gustafsson Nils-Ove,SEX
  • Laakso Timo,SEX
  • Fyhr Peter,SEX
  • Jonsson Monica,SEX
출원인 / 주소
  • Biogram AB, SEX
대리인 / 주소
    Burns, Doane, Swecker & Mathis, L.L.P.
인용정보 피인용 횟수 : 50  인용 특허 : 14

초록

A method of preparing parenterally administrable sustained release microparticles, which comprises preparing core particles in an aqueous medium that is essentially free from organic solvent, a biologically active substance being entrapped therein during or after said preparation, drying the core pa

대표청구항

[ What is claimed is:] [1.] A method for preparing parenterally administerable, sustained release microparticles containing a biologically active substance, which method comprises (i) preparing core particles from a biodegradable material in an aqueous medium which substantially lacks any organic so

이 특허에 인용된 특허 (14)

  1. Nuwayser Elie S. (Wellesley MA) Nucefora William A. (Bedford MA), Composite core coated microparticles and process of preparing same.
  2. Nuwayser Elie S. (Wellesley MA) Nucefora William A. (Bedford MA), Controlled release composite core coated microparticles.
  3. Shalati Mohamad D. (Richton Park IL) Sivaramakrishnan Kallidaikurichi N. (Terre Haute IN), Controlled release delivery system for macromolecules.
  4. Modi Pankaj (1298 Main St. W. ; Apt. 608 Hamilton ; Ontario CAX L8S 1J4), Controlled release of drugs or hormones in biodegradable polymer microspheres.
  5. Tanaka Motoaki (Urawa JPX) Ogawa Yasuaki (Ibaraki JPX) Miyagawa Tsutomu (Kawagoe JPX) Watanabe Toshio (Kawagoe JPX), Copolymer and method for producing the same.
  6. Amer Moh. S. (Carpinteria CA) Tawashi Rashad (Beaconsfield CAX), Drug loaded pollen grains with an outer coating for pulsed delivery.
  7. Ekman Bo (MalmSEX) Lindahl ke (Skurup SEX), Method for producing small, spherical polymer particles.
  8. Yamamoto Masaki (Osaka JPX) Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Miyagawa Tsutomu (Saitama JPX), Polymer, production and use thereof.
  9. McGinity James W. (Austin TX) Iwata Motokazu (Osaka JPX), Preparation and uses of multi-phase microspheres.
  10. Tice Thomas R. (Birmingham AL) Orsolini Piero (Martigny LA CHX) Schally Andrew V. (New Orleans LA), Process for increasing the antagonistic effect of peptidic compounds on hormone-dependent diseases.
  11. Fong, Jones W., Process for preparation of microspheres.
  12. Fong Jones W. (Parsippany NJ), Process for preparation of microspheres and modification of release rate of core material.
  13. Gardner David L. (Bellville OH), Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or e 상세보기
  • Bernstein Howard (Cambridge MA) Morrel Eric (Needham MA) Mathiowitz Edith (Brookline MA) Schwaller Kirsten (Duxbury MA) Beck Thomas R. (Concord MA), Protein microspheres and methods of using them.
  • 이 특허를 인용한 특허 (50)

    1. Nathan, Aruna, Alkyd-lactone copolymers for medical applications.
    2. Nathan,Aruna, Amphiphilic polymers for medical applications.
    3. Alavattam,Sreedhara; Brody,Richard S., Biodegradable microparticles that stabilize and control the release of proteins.
    4. Nathan,Aruna; Melican,Mora C.; Brown,Kelly R.; Zimmerman,Mark C., Bone replacement materials utilizing bioabsorbable liquid polymers.
    5. Nathan, Aruna, Cationic alkyd polyesters for medical applications.
    6. Avalle, Nadia, Coated cosmetic powder.
    7. Smith, Thomas J., Coated particles for sustained-release pharmaceutical administration.
    8. Nathan,Aruna; Rosenblatt,Joel; Arnold,Steven C., Composition and medical devices utilizing bioabsorbable polymeric waxes.
    9. Nathan, Aruna; Rosenblatt, Joel; Arnold, Steven C., Compositions and medical devices utilizing bioabsorbable liquid polymers.
    10. Nathan,Aruna; Rosenblatt,Joel; Arnold,Steven C., Compositions and medical devices utilizing bioabsorbable liquid polymers.
    11. Arnold,Steven; Nathan,Aruna; Rosenblatt,Joel, Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin.
    12. Tengler, Mark; McMahen, Russell, Compositions and methods of making rapidly dissolving ionically masked formulations.
    13. Tengler, Mark; Taskey, Paul; Lockhart, Daniel; McMahen, Russ, Compositions and methods of making sustained release liquid formulations.
    14. Tengler, Mark; Taskey, Paul; Lockhart, Daniel; McMahen, Russell, Compositions and methods of making sustained release liquid formulations.
    15. Leung, Karling Alice, Compositions, devices and methods of use thereof for the treatment of cancers.
    16. Gustafsson, Nils Ove; Jonsson, Monica; Laakso, Timo, Cores and microcapsules suitable for parenteral administration as well as process for their manufacture.
    17. Brown, Larry R.; Bisker-Leib, Vered; Scott, Terrence L.; Lafreniere, Debra; Machen, Jennifer; Giannoukakis, Nick, Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes.
    18. Brown, Larry R.; Bisker-Leib, Vered; Scott, Terrence L.; Lafreniere, Debra; Machen, Jennifer; Giannoukakls, Nick, Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes.
    19. Nathan, Aruna, Functionalized polymers for medical applications.
    20. Smith, Jay S.; Cole, Michael R.; Whitson, Amy K., Implant placement guide.
    21. Smith, Jay S.; Cole, Michael R.; Whitson, Amy K., Implant placement guide.
    22. Nathan,Aruna; Rosenblatt,Joel; Arnold,Steven C., Injectable microdispersions for medical applications.
    23. Helliwell, James A.; Malone, Amanda M.; Smith, Thomas J.; Baum, Marc M., Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith.
    24. Brown, Larry; McGeehan, John K.; Rashba-Step, Julia; Scott, Terrence L., Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation.
    25. Darvari, Ramin; Lambert, Adam; Rashba-Step, Julia E.; Yang, Mark X.; Zhang, Junhong; O'Connell, Ed, Methods of processing compositions containing microparticles.
    26. Piran, Uri; Mehr, Eugene; Brown, Larry R.; McGeehan, John K.; O'Connell, Ed, Methods of processing compositions containing microparticles.
    27. Piran, Uri, Methods of processing multi-phasic dispersions.
    28. Brown, Larry R.; Giannoukakis, Nick; Gillis, Kimberly A.; Trucco, Massimo, Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes.
    29. Pathak, Yashwant Vishnupant; McMahen, Russell Lee; Tengler, Mark, Modifying drug release in suspensions of ionic resin systems.
    30. Brown, Larry R.; Scott, Terrence L.; Lafreniere, Debra; Bisker-Leib, Vered, Nucleic acid microspheres, production and delivery thereof.
    31. Scott, Terrence; Lafreniere, Debra; Bisker-Leib, Vered; Brown, Larry, Nucleic acid microspheres, production and delivery thereof.
    32. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R.; Smith, Christine; Lokensgard, David M.; Fineman, Mark; Ong, John, Poly(lactide-co-glycolide) based sustained release microcapsules comprising a polypeptide and a sugar.
    33. Rosenblatt,Joel; Cui,Han; Kataria,Ram L.; Wu,Chuanbin, Polymer coated microparticles for sustained release.
    34. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
    35. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
    36. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
    37. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
    38. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
    39. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Fineman, Mark; Smith, Christine; Ong, John; Lokensgard, David M.; Costantino, Henry R., Polymer-based sustained release device.
    40. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Fineman, Mark; Smith, Christine; Ong, John; Lokensgard, David; Costantino, Henry R., Polymer-based sustained release device.
    41. Wright,Steven G.; Christenson,Troy; Yeah,Thean Y.; Rickey,Michael E.; Hotz,Joyce M.; Kumar,Rajesh; Costantino,Henry R., Polymer-based sustained release device.
    42. Brown,Larry R., Production of microspheres.
    43. Brown, Larry; Bisker-Leib, Vered; LaFreniere, Debra; McGeehan, John; Rashba-Step, Julia; Scott, Terrence, Protein microspheres having injectable properties at high concentrations.
    44. Brown, Larry R.; Yang, Mark X.; O'Connell, Ed, Protein microspheres retaining pharmacokinetic and pharmacodynamic properties.
    45. Alessi, Thomas R.; Luskey, Kenneth, Rapid establishment and/or termination of substantial steady-state drug delivery.
    46. Rickey, Michael E.; Ramstack, J. Michael; Kumar, Rajesh, Residual solvent extraction method and microparticles produced thereby.
    47. Rickey, Michael E.; Ramstack, J. Michael; Kumar, Rajesh, Residual solvent extraction method and microparticles produced thereby.
    48. Rickey, Michael E.; Ramstack, J. Michael; Kumar, Rajesh, Residual solvent extraction method and microparticles produced thereby.
    49. Dadey, Eric; Zhou, Mingxing, Stabilized polymeric delivery system comprising a water-insoluble polymer and an organic liquid.
    50. Alessi, Thomas R.; Baron, Michelle, Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c.
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