IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0455604
(1995-05-31)
|
우선권정보 |
WOFR-04471 (1990-04-06) |
발명자
/ 주소 |
- Spenlehauer Gilles,FRX
- Veillard Michel,FRX
- Verrechia Thierry,FRX
|
출원인 / 주소 |
- Rhone-Poulenc Rorer SA, FRX
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
35 인용 특허 :
8 |
초록
▼
Biocompatible microspheres containing one or more active principals, a biodegradable and biocompatible polymer and a surface-active agent which is also biodegradable and biocompatible, contain less than 10 ppm of heavy metals. These microspheres are prepared by providing a solution of the polymer an
Biocompatible microspheres containing one or more active principals, a biodegradable and biocompatible polymer and a surface-active agent which is also biodegradable and biocompatible, contain less than 10 ppm of heavy metals. These microspheres are prepared by providing a solution of the polymer and of the active principal in a water-immiscible solvent which is more volatile than water and mixing with an aqueous solution of the surface-active agent, followed by evaporation of the solvent.
대표청구항
▼
[ We claim:] [1.] A process for preparing a composition of biocompatible microspheres, the process comprising the following steps:(a) preparing a first solution comprising (i) a biodegradable and biocompatible polymer, the polymer selected from the group consisting of homopolymers of lactic acid, ho
[ We claim:] [1.] A process for preparing a composition of biocompatible microspheres, the process comprising the following steps:(a) preparing a first solution comprising (i) a biodegradable and biocompatible polymer, the polymer selected from the group consisting of homopolymers of lactic acid, homopolymers of glycolic acid, copolymers of lactic acid and glycolic acid, polymers of polyhydroxybutyric acid, polylactones of fatty acid containing more than twelve carbon atoms, polyorthoesters, fatty acid polyhydroxyesters having more than twelve carbon atoms, and polyanhydrides, and (ii) an active principal selected from the group consisting of anti-inflammatory agents, antibacterial agents, anticancer agents, agents having an action on the heart, and diagnostic agents, in a water-immiscible solvent, the solvent being more volatile than water;(b) preparing a second solution in water comprising a biodegradable and biocompatible surface-active agent selected from the group consisting of serum albumin, fetuin, orosmuccoid, glycoproteins, immunoglobulins, gelatin, collagen, bile salts, phospholipid, and lipopolysaccharide;(c) mixing the first solution with the second solution to form an aqueous emulsion by using a high pressure homogenizer capable of producing pressure of about 10.sup.5 to about 11.times.10.sup.5 Pa; and(d) evaporating the water-immiscible solvent;wherein the aqueous emulsion contains less than about 10 ppm of heavy metals, the microspheres have a particle diameter of between about 0.05 micron and about 1 micron, the active principal is present as about 0.05 to about 20% by weight of the composition, the biodegradable and biocompatible polymer is present as about 0.1 to about 40% by weight of the composition, the biodegradable and biocompatible surface-active agent is present as about 0.2 to about 20% by weight of the composition, and water is present as about 20 to about 99.65% by weight of the composition.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.