Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/44
C07D-021/304
출원번호
US-0127620
(1998-08-01)
발명자
/ 주소
Fernandez-Pol Jose A.
출원인 / 주소
Novactyl, Inc.
대리인 / 주소
Polster, Lieder, Woodruff & Lucchesi, LC.
인용정보
피인용 횟수 :
17인용 특허 :
18
초록▼
An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes required for growth, replication or inflammatory resp
An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes required for growth, replication or inflammatory response. The preparations can be administered systemically or for topical use. The preparations have antineoplastic, antiviral, antiinflammatory and antiproliferative effects and are used in the treatment of warts, psoriasis, acne, skin cancers, sunburn and other proliferative diseases and in the prevention of sexually transmitted diseases such as genital warts, herpes and AIDS. The agents also can be used to induce autologous immunological response.
대표청구항▼
[ What is claimed is:] [1.] A method of treating a disease selected from the group consisting of papilloma virus infections, plantar ulcer, proliferative skin disorders, actinic lesions, herpes infections, hepatitis virus infections, human immunodeficiency virus infections or metastatic disease sele
[ What is claimed is:] [1.] A method of treating a disease selected from the group consisting of papilloma virus infections, plantar ulcer, proliferative skin disorders, actinic lesions, herpes infections, hepatitis virus infections, human immunodeficiency virus infections or metastatic disease selected from the group consisting of cancer of breast, prostate, cervix, skin, colon, liver and lung, wherein the disease is mediated by a protein having a transition metal ion-protein complex, the method comprising the administration of therapeutically effective amount of an agent to inactivate the metal-ion, protein complex, the agent having the following structure: [ STR 1 ] or a pharmaceutically acceptable salt thereof wherein R1, R2, R3 and R4 are selected from the group consisting of a carboxyl group, methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, secondary butyl group, tertiary butyl group, pentyl group, isopentyl group, neopentyl group; fluorine, chlorine, bromine, iodine and hydrogen.
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