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특허 상세정보

Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-031/44    C07D-021/304   
미국특허분류(USC) 51/4354 ; 54/632.6 ; 54/632.1 ; 54/631.4 ; 51/435.6
출원번호 US-0127620 (1998-08-01)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Polster, Lieder, Woodruff & Lucchesi, LC.
인용정보 피인용 횟수 : 17  인용 특허 : 18
초록

An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes required for growth, replication or inflammatory response. The preparations can be administered systemically or for topical use. The preparations have antineoplastic, antiviral, antiinflammatory and antiproliferative effects and are used in the treatment of warts, psoriasis, acne, skin cancers, sunburn and other...

대표
청구항

[ What is claimed is:] [1.] A method of treating a disease selected from the group consisting of papilloma virus infections, plantar ulcer, proliferative skin disorders, actinic lesions, herpes infections, hepatitis virus infections, human immunodeficiency virus infections or metastatic disease selected from the group consisting of cancer of breast, prostate, cervix, skin, colon, liver and lung, wherein the disease is mediated by a protein having a transition metal ion-protein complex, the method comprising the administration of therapeutically effective...

이 특허에 인용된 특허 (18)

  1. Kun Ernest (Mill Valley CA) Mendeleyev Jerome (San Francisco CA). 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents. USP1996015484951.
  2. Yano Mitsuo (Yokohama JPX) Yoshizawa Junji (Machida JPX) Ishikawa Kiyofumi (Chofu JPX) Harada Nobuo (Okazaki JPX) Matsumoto Ikuo (Tokyo JPX). a
  3. Rupprecht Kathleen (Cranford NJ) Baker Robert (Cranford NJ). Alkylidene macrolides having immunosuppressive activity. USP1994025284840.
  4. Taguchi Shigeru (Yokohama JPX) Suzuki Takashi (Yokohama JPX) Nishino Chikao (Yokohama JPX) Fujinuma Yoshimori (Yokohama JPX) Yanagawa Chuji (Sagamihara JPX) Yamaguchi Michihiro (Yokohama JPX) Yamato . Antipruritic composition. USP1993065219847.
  5. Fernandez-Pol Jose Alberto. Antiviral agent. USP1998065767135.
  6. Monkovic Ivo (Durham CT) Wang Lotte (North Haven CT). Dibenz[b,f][1,4]oxazepin-11(10H)-ones for multidrug resistance reversing agents. USP1992125173486.
  7. Sviokla ; Sylvester Charles. Electrochemical recording medium. USP1978104120762.
  8. Borgman Robert J. (Mundelein IL). Intravaginal treatment of vaginal infections with buffered metronidazole compositions. USP1996075536743.
  9. Evans Gary W. (Puposky MN) Peppler Henry J. (Whitefish Bay WI). Means and method for increasing skin respiration. USP1991105057320.
  10. Henderson Louis E. ; Arthur Larry O. ; Rice William G. ; Rein Alan R.. Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein. USP1999126001555.
  11. Van Wauwe Jean P. F. (Beerse BEX) Raeymaekers Alfons H. M. (Beerse BEX). Method of treating epithelial disorders. USP1992105157046.
  12. Lewis Charles (Kalamazoo Township ; Kalamozoo County MI) Birkenmeyer Robert D. (Comstock Township ; Kalamazoo County MI). Method of treating malaria. USP1981104293547.
  13. Takabe Fumiaki (Shizuoka JPX) Saito Yoshihiro (Shizuoka JPX) Tamaru Masatoshi (Shizuoka JPX) Tachikawa Shigehiko (Shizuoka JPX) Hanai Ryo (Shizuoka JPX). Picolinic acid derivative and herbicidal composition. USP1995045403816.
  14. Takabe Fumiaki (Iwata JPX) Saito Yoshihiro (Kakegawa JPX) Tamaru Masatoshi (Kakegawa JPX) Tachikawa Shigehiko (Shizuoka JPX) Hanai Ryo (Ogasa JPX). Picolinic acid derivative, and herbicidal composition. USP1995025391537.
  15. Mathews Roger A. (Newbury Park CA) Cannell David W. (Los Angeles CA). Scalp treatment. USP1989034814351.
  16. Kun Ernest (Mill Valley CA) Mendeleyev Jerome (San Francisco CA). Specific inactivators of “retroviral”(asymmetric) zinc fingers. USP1996055516941.
  17. Sherlock Margaret H. (Bloomfield NJ). Trityl picolinic acid derivatives and their use as anti-acne agents. USP1977084044140.
  18. Vincent Michel (Bagneux FRX) Remond Georges (Versailles FRX) Herve Yolande (Puteaux FRX) Boutin Jean-Albert (Suresnes FRX). Use of N-myristoyl-(S)-phenylalanine for the treatment of diseases involving myristoylation. USP1992115164414.

이 특허를 인용한 특허 피인용횟수: 17

  1. Fernandez-Pol, Jose A.. Agent and method for prevention and treatment of cancer in animals. USP2003066579891.
  2. Newman, Bradley R.. Device for mitigating plantar fasciitis. USP2016029259343.
  3. Bamdad, Cynthia C.. Diagnostic tumor markers, drug screening for tumorigenesis inhibition, and compositions and methods for treatment of cancer. USP2013018344113.
  4. Bamdad, Cynthia C.; Bamdad, R. Shoshana. Diagnostic tumor markers, drug screening for tumorigenesis inhibition, and compositions and methods for treatment of cancer. USP2010047700715.
  5. Rothman, James; Hartl, F. Ulrich; Hoe, Mee H.; Houghton, Alan; Takechi, Yoshizumi; Mayhew, Mark. Heat shock protein-based vaccines and immunotherapies. USP2009117618637.
  6. Slusarewicz,Paul; Flechtner,Jessica Baker; Mehta,Sunil; Prince Cohane,Kenya; Andjelic,Sofija; Barber,Brian H.. Heat shock protein-based vaccines and immunotherapies. USP2007127309491.
  7. Slusarewicz,Paul; Mehta,Sunil. Heat shock protein-based vaccines and immunotherapies. USP2008097420037.
  8. Chang, Yunik; Lathrop, Robert; Böhm, Erwin; Gander-Meisterernst, Irene; Greger, Regina; Holldack, Johanna; Moebius, Ulrich. Medicament for the treatment of viral skin and tumour diseases. USP2010127858662.
  9. Chang, Yunik; Lathrop, Robert; Böhm, Erwin; Gander-Meisterernst, Irene; Greger, Regina; Holldack, Johanna; Moebius, Ulrich. Medicament for the treatment of viral skin and tumour diseases. USP2017099770406.
  10. Weller, Michael; Wick, Wolfgang; Wischhusen, Jörg; Platten, Michael. Method of modulating cellular activity and agents useful for same. USP2009057531575.
  11. Douglas, Michael G.; Amin, Avinash N.. Methods and compositions for controlling protein assembly or aggregation. USP2004066743771.
  12. Jose A. Fernandez-Pol. Methods of inactivating a virus and controlling viral replication. USP2002066410570.
  13. Fernandez-Pol, Jose A.; Fernandez-Pol, Sebastian. PHARMACOLOGICAL AGENTS AND METHODS OF TREATMENT THAT INACTIVATE PATHOGENIC PROKARYOTIC AND EUKARYOTIC CELLS AND VIRUSES BY ATTACKING HIGHLY CONSERVED DOMAINS IN STRUCTURAL METALLOPROTEIN AND METALLOE. USP2004106803379.
  14. Douglas, Michael G.; Amin, Avinash N.. Pharmaceutical agents containing acyclovir, fusaric acid and derivatives thereof. USP2005096939884.
  15. Douglas, Michael G.; Amin, Avinash N.. Pharmaceutical agents containing acyclovir, fusaric acid and derivatives thereof. USP2003056569864.
  16. Stockfleth, Eggert. Use of a polyphenol for the treatment of a cancerous or pre-cancerous lesion of the skin. USP2015069060998.
  17. Stockfleth, Eggert. Use of a polyphenol for the treatment of a cancerous or precancerous lesion of the skin. USP2013068455022.